Assessment of plasma antioxidant capacity and oxidative stress in HIV/AIDS patients in Calabar, Nigeria

Ojong, Ebot Walter; Bassey, Iya Eze; Nsonwu-Anyanwu, Augusta Chinyere; Ndeh, Forwah Jacques; Djeufouata, Jules; Njongang, Vigny N.; Etukudo, Maisie Henrietta; Usoro, Chinyere Adanna Opara

doi:10.1016/j.sciaf.2021.e01017

Cited by 2 publications

(2 citation statements)

References 24 publications

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“…However, as the hallmark of endothelial dysfunction is driven by reduction in NO release and increase generation of ROS, which can occur in the setting of HIV, potential therapies such as antioxidant therapy can be considered in the HIV population in the control of ENaC driven hypertension. Studies have indicated that PWH, including those on cART have high levels of total plasma peroxides and oxidative stress index compared to the control group ( 210 ). Preclinical studies have demonstrated that therapies which improves NO bioavailability, such as Lazaroids (inhibitors of lipid membrane peroxidation and appear to function as oxygen free radical scavengers) have been shown to reduce blood pressure in animal models ( 211 ).…”

Section: Sex Differences Epithelial Sodium Channel and Hypertension I...mentioning

confidence: 99%

Hypertension and human immunodeficiency virus: A paradigm for epithelial sodium channels?

Mutengo

Masenga

Mwesigwa

et al. 2022

Front. Cardiovasc. Med.

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Hypertension is a risk factor for end organ damage and death and is more common in persons with HIV compared to the general population. Several mechanisms have been studied in the pathogenesis of hypertension. Current evidence suggests that the epithelial sodium channel (ENaC) plays a key role in regulating blood pressure through the transport of sodium and water across membranes in the kidney tubules, resulting in retention of sodium and water and an altered fluid balance. However, there is scarcity of information that elucidates the role of ENaC in HIV as it relates to increasing the risk for development or pathogenesis of hypertension. This review summarized the evidence to date implicating a potential role for altered ENaC activity in contributing to hypertension in patients with HIV.

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Section: Sex Differences Epithelial Sodium Channel and Hypertension I...mentioning

confidence: 99%

Hypertension and human immunodeficiency virus: A paradigm for epithelial sodium channels?

Mutengo

Masenga

Mwesigwa

et al. 2022

Front. Cardiovasc. Med.

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“…Normally, ROS is maintained at low level by antioxidant pathways and act as secondary messengers 42 . However, loss of ROS balance is a characteristic of mitochondrial dysfunction, and markers of oxidative stress due to ROS are often elevated among PLWH compared to controls 43 , 44 linked to HIV viral products and treatments 45 . The interplay of ROS imbalance and mitochondrial dysfunction can be detrimental to cell metabolism and cell repair.…”

Section: Introductionmentioning

confidence: 99%

Mitochondrial DNA copy number is associated with incident chronic kidney disease and proteinuria in the AIDS linked to the intravenous experience cohort

Tewari,

Kirk,

Arking

et al. 2023

Sci Rep

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We evaluated the prospective association of mitochondrial DNA copy number (mtDNA CN) with markers of kidney function among a cohort of persons who inject drugs (PWID). This is a Prospective cohort study nested in the AIDS linked to the intravenous experience cohort (community-based cohort of PWID in Baltimore, MD). mtDNA CN was measured at two time-points 5 years apart using a real-time polymerase chain reaction. Kidney function (estimated glomerular filtration rate [eGFR], serum creatinine, urine protein) was measured annually. We used linear mixed effects models to evaluate kidney function trajectories (N = 946) and Cox regression models to assess hazard of incident CKD (eGFR < 60 at two consecutive visits, N = 739) and proteinuria (urine protein:creatinine ratio > 200, N = 573) by level of mtDNA CN (Low [lowest quartile], vs high [other three quartiles]. Models were adjusted for demographic and behavioral characteristics, HIV and/or HCV infection, and comorbidity burden. Low mtDNA CN was independently associated with higher hazard of incident CKD (aHR: 2.33, 95% CI 1.42, 3.80) and proteinuria (aHR: 1.42, 95% CI 1.04, 1.96). Participants with low mtDNA CN had greater declines in eGFR and greater increases in serum creatinine over time. Low mtDNA CN is associated with more rapid kidney function decline and risk of incident CKD and proteinuria.

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Assessment of plasma antioxidant capacity and oxidative stress in HIV/AIDS patients in Calabar, Nigeria

Cited by 2 publications

References 24 publications

Hypertension and human immunodeficiency virus: A paradigm for epithelial sodium channels?

Hypertension and human immunodeficiency virus: A paradigm for epithelial sodium channels?

Mitochondrial DNA copy number is associated with incident chronic kidney disease and proteinuria in the AIDS linked to the intravenous experience cohort

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