Assessment of Pharmacokinetic Parameters of Daidzein-Containing Nanosuspension and Nanoemulsion Formulations After Oral Administration to Rats

Demirtürk, Esra; Kaplan, Afife Büşra Uğur; Çetin, Meltem; Akıllıoğlu, Kübra; Kutlu, Meltem Dönmez; Köse, Seda; Aksu, Fazilet

doi:10.1007/s13318-021-00746-5

Cited by 7 publications

(3 citation statements)

References 35 publications

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“…Further experiments, including the anticancer and anti-metastasis analysis of daidzein on lung cancer cells, should be conducted to confirm the network pharmacological results. The biological effects of daidzein include antioxidation, anti-inflammation, chemoprevention, and anticancer properties [ 78 ]. There have been reports that this compound exhibits anticancer properties against different types of cancer, including breast and ovarian cancers [ 79 , 80 ].…”

Section: Discussionmentioning

confidence: 99%

Integrated Network Pharmacology, Molecular Docking, Molecular Simulation, and In Vitro Validation Revealed the Bioactive Components in Soy-Fermented Food Products and the Underlying Mechanistic Pathways in Lung Cancer

Elkhalifa,

Banu,

Khan

et al. 2023

Nutrients

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Globally, lung cancer remains one of the leading causes of cancer-related mortality, warranting the exploration of novel and effective therapeutic approaches. Soy-fermented food products have long been associated with potential health benefits, including anticancer properties. There is still a lack of understanding of the active components of these drugs as well as their underlying mechanistic pathways responsible for their anti-lung cancer effects. In this study, we have undertaken an integrated approach combining network pharmacology and molecular docking to elucidate the mechanism of action of soy-fermented food products against lung cancer through simulation and in vitro validation. Using network pharmacology, we constructed a comprehensive network of interactions between the identified isoflavones in soy-fermented food products and lung cancer-associated targets. Molecular docking was performed to predict the binding affinities of these compounds with key lung cancer-related proteins. Additionally, molecular simulation was utilized to investigate the stability of the compound–target complexes over time, providing insights into their dynamic interactions. Our results identified daidzein as a potential active component in soy-fermented food products with high binding affinities towards critical lung cancer targets. Molecular dynamic simulations confirmed the stability of the daidzein–MMP9 and daidzein–HSP90AA1 complexes, suggesting their potential as effective inhibitors. Additionally, in vitro validation experiments demonstrated that treatment with daidzein significantly inhibited cancer cell proliferation and suppressed cancer cell migration and the invasion of A549 lung cancer cells. Consequently, the estrogen signaling pathway was recognized as the pathway modulated by daidzein against lung cancer. Overall, the findings of the present study highlight the therapeutic potential of soy-fermented food products in lung cancer treatment and provide valuable insights for the development of targeted therapies using the identified bioactive compounds. Further investigation and clinical studies are warranted to validate these findings and translate them into clinical applications for improved lung cancer management.

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Section: Discussionmentioning

confidence: 99%

Integrated Network Pharmacology, Molecular Docking, Molecular Simulation, and In Vitro Validation Revealed the Bioactive Components in Soy-Fermented Food Products and the Underlying Mechanistic Pathways in Lung Cancer

Elkhalifa,

Banu,

Khan

et al. 2023

Nutrients

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“…39 Nano-sized formulations are beneficial dosage forms to improve the poor aqueous solubility of drugs. 40 We fabricated a milk exosome platform functionalized with PS to improve the solubility of poorly soluble drugs, resulting in enhanced efficiency for oral delivery. Such exosomes also have the characteristics of natural carriers, which enhanced the mucus permeability of loaded drugs.…”

Section: ■ Discussionmentioning

confidence: 99%

“…Solubility is an important factor to overcome oral delivery barriers and enhancing the efficacy of antibacterial agents that belong to BCS class II and class IV compounds . Nano-sized formulations are beneficial dosage forms to improve the poor aqueous solubility of drugs . We fabricated a milk exosome platform functionalized with PS to improve the solubility of poorly soluble drugs, resulting in enhanced efficiency for oral delivery.…”

Section: Discussionmentioning

confidence: 99%

Milk Exosomes Facilitate Oral Delivery of Drugs against Intestinal Bacterial Infections

Han

Liu

et al. 2022

J. Agric. Food Chem.

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Biopharmaceutics Classification System (BCS) class II and IV drugs exhibit low solubility and suffer a limitation in oral administration. Exosomes have attracted intensive attention in the efficient delivery of such compounds. However, low gastrointestinal stability and high production cost of exosomes hinder their development as drug carriers. Here, milk exosomes are functionalized with phosphatidylserine and are capable of improving the solubility of BCS class II and IV drugs, resulting in facilitating the oral delivery of the drugs. A natural flavonoid, α-mangostin, is loaded into exosomes (AExo) to enhance the antibacterial efficiency, demonstrated by clearing 99% of bacteria in macrophages. Furthermore, AExo exhibits high mucus penetrability and shows a significant therapeutic efficacy in two animal infection models. Collectively, this work expands the application of exosomes from bovine milk with simple operation and low cost, shedding light on the potential of milk exosomes in improving the solubility of drugs to enhance the efficacy of oral administration.

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Daidzein nanosuspension in combination with cisplatin to enhance therapeutic efficacy against A549 non-small lung cancer cells: an in vitro evaluation

Oncu,

Becit-Kizilkaya,

Sen

et al. 2023

Naunyn-Schmiedeberg's Arch Pharmacol

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Assessment of Pharmacokinetic Parameters of Daidzein-Containing Nanosuspension and Nanoemulsion Formulations After Oral Administration to Rats

Cited by 7 publications

References 35 publications

Integrated Network Pharmacology, Molecular Docking, Molecular Simulation, and In Vitro Validation Revealed the Bioactive Components in Soy-Fermented Food Products and the Underlying Mechanistic Pathways in Lung Cancer

Integrated Network Pharmacology, Molecular Docking, Molecular Simulation, and In Vitro Validation Revealed the Bioactive Components in Soy-Fermented Food Products and the Underlying Mechanistic Pathways in Lung Cancer

Milk Exosomes Facilitate Oral Delivery of Drugs against Intestinal Bacterial Infections

Daidzein nanosuspension in combination with cisplatin to enhance therapeutic efficacy against A549 non-small lung cancer cells: an in vitro evaluation

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