Assessment of pH Responsive Delivery of Methotrexate Based on PHEMA-st-PEG-DA Nanohydrogels

Farzanfar, Javad; Farjadian, Fatemeh; Roointan, Amir; Mohammadi-Samani, Soliman; Tayebi, Lobat

doi:10.1007/s13233-021-9007-6

Cited by 22 publications

(6 citation statements)

References 38 publications

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“…PHEMA and PEG-DA conjugated nanohydrogel induced cytotoxicity in the MCF-7 cancer cells. pH-responsive conjugate enhanced the toxicity and cellular uptake in a cancer animal model (Farzanfar et al, 2021).…”

Section: Stimuli-responsive Polymeric Nanoparticlesmentioning

confidence: 99%

Nanocarriers for methotrexate delivery/codelivery in the frame of cancer diagnostics and treatment: a review

Mukhtar,

Ezra Manicum,

Shojaei Barjouei

et al. 2023

Front. Biomater. Sci.

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Cancer is one of the most life-threatening family of diseases that cause death worldwide. As a highly researched and successful therapeutic agent, methotrexate (MTX) treats many solid tumours, hematologic malignancies, and autoimmune illnesses. Despite many benefits, methotrexate induces drug resistance and limits plasma half-life due to its poor pharmacokinetics. The variable biological availability have prompted researchers to investigate innovative delivery strategies for enhancing its therapeutic qualities. To develop more suitable methotrexate formulations, nanoparticles (NPs) have recently gained a significant interest. A wide range of nanoparticles, including polymer-based nanoparticles, carbon-based nanoparticles, lipid-based nanoparticles, as well as inorganic nanoparticles, can be deliver cancer chemotherapeutics such as methotrexate. Loading methotrexate into NPs can provide a delivery system that has shown great promise to carcinoma therapy. In this review, we will describe the feasibility of NP-based strategies to deliver methotrexate in cancer therapy, outlining the current state of the art and the challenges/promises for the future.

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Section: Stimuli-responsive Polymeric Nanoparticlesmentioning

confidence: 99%

Nanocarriers for methotrexate delivery/codelivery in the frame of cancer diagnostics and treatment: a review

Mukhtar,

Ezra Manicum,

Shojaei Barjouei

et al. 2023

Front. Biomater. Sci.

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“…Research on hydrogel has been ongoing for many years, leading to the development of products that have found numerous applications in the drug delivery system. Therapeutic drugs are now loaded into polymer-based carriers, and the delivery and release of drug molecules is a topic of great interest in many medical fields ( Roointan et al, 2018 ; Farjadian et al, 2019a ; Farjadian et al, 2020 ; Farzanfar et al, 2021 ; Ghasemi et al, 2022a ; Bahmani et al, 2022 ). The carriers facilitate the transportation of drugs to the specific target location ( Entezar-Almahdi et al, 2021 ; Ghasemi et al, 2022b ).…”

Section: Introductionmentioning

confidence: 99%

Commercial hydrogel product for drug delivery based on route of administration

Raeisi,

Farjadian

2024

Front. Chem.

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Hydrogels are hydrophilic, three-dimensional, cross-linked polymers that absorb significant amounts of biological fluids or water. Hydrogels possess several favorable properties, including flexibility, stimulus-responsiveness, versatility, and structural composition. They can be categorized according to their sources, synthesis route, response to stimulus, and application. Controlling the cross-link density matrix and the hydrogels’ attraction to water while they’re swelling makes it easy to change their porous structure, which makes them ideal for drug delivery. Hydrogel in drug delivery can be achieved by various routes involving injectable, oral, buccal, vaginal, ocular, and transdermal administration routes. The hydrogel market is expected to grow from its 2019 valuation of USD 22.1 billion to USD 31.4 billion by 2027. Commercial hydrogels are helpful for various drug delivery applications, such as transdermal patches with controlled release characteristics, stimuli-responsive hydrogels for oral administration, and localized delivery via parenteral means. Here, we are mainly focused on the commercial hydrogel products used for drug delivery based on the described route of administration.

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“…Smart delivery of MTX can be achieved by establishing an ester linkage that allows the drug to be released at the pH of the tumor site. Hydroxyl-modified magnetite nanoparticles and a polyhydroxyethylmethacrylate hydrogel have been embedded to fulfill this purpose in two of our previous investigations [31,32].…”

Section: Introductionmentioning

confidence: 99%

Glucosamine-Modified Mesoporous Silica-Coated Magnetic Nanoparticles: A “Raisin-Cake”-like Structure as an Efficient Theranostic Platform for Targeted Methotrexate Delivery

Farjadian,

Faghih,

Fakhimi

et al. 2023

Pharmaceutics

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This study presents the synthesis of glucosamine-modified mesoporous silica-coated magnetic nanoparticles (MNPs) as a therapeutic platform for the delivery of an anticancer drug, methotrexate (MTX). The MNPs were coated with mesoporous silica in a templated sol–gel process to form MNP@MSN, and then chloropropyl groups were added to the structure in a post-modification reaction. Glucosamine was then reacted with the chloro-modified structure, and methotrexate was conjugated to the hydroxyl group of the glucose. The prepared structure was characterized using techniques such as Fourier transform infrared (FT-IR) spectroscopy, elemental analysis (CHN), field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), dynamic light scattering (DLS), a vibrating sample magnetometer (VSM), and X-ray diffraction (XRD). Good formation of nano-sized MNPs and MNP@MSN was observed via particle size monitoring. The modified glucosamine structure showed a controlled release profile of methotrexate in simulated tumor fluid. In vitro evaluation using the 4T1 breast cancer cell line showed the cytotoxicity, apoptosis, and cell cycle effects of methotrexate. The MTT assay showed comparable toxicity between MTX-loaded nanoparticles and free MTX. The structure could act as a glucose transporter-targeting agent and showed increased uptake in cancer cells. An in vivo breast cancer model was established in BALB/C mice, and the distribution of MTX-conjugated MNP@MSN particles was visualized using MRI. The MTX-conjugated particles showed significant anti-tumor potential together with MRI contrast enhancement.

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Assessment of pH Responsive Delivery of Methotrexate Based on PHEMA-st-PEG-DA Nanohydrogels

Cited by 22 publications

References 38 publications

Nanocarriers for methotrexate delivery/codelivery in the frame of cancer diagnostics and treatment: a review

Nanocarriers for methotrexate delivery/codelivery in the frame of cancer diagnostics and treatment: a review

Commercial hydrogel product for drug delivery based on route of administration

Glucosamine-Modified Mesoporous Silica-Coated Magnetic Nanoparticles: A “Raisin-Cake”-like Structure as an Efficient Theranostic Platform for Targeted Methotrexate Delivery

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