Assessment of Peripheral Neuropathy Using Measurement of the Current Perception Threshold with the Neurometer® in Patients with Type 2 Diabetes Mellitus

Matsutomo, Rika; Takebayashi, Kohzo; Aso, Yoshimasa

doi:10.1177/147323000503300410

Cited by 51 publications

(52 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The pulses at 2,000, 250, and 5 Hz mainly stimulate large myelinated (A␤-), small myelinated (A␦-), and small unmyelinated (C-) fibers, respectively. The neurometer is now widely used clinically to evaluate the effects of analgesic drugs and peripheral nerve function in various painful neuropathies, including DPN (45)(46)(47)(48). Although previous studies (15,49 -51) reported methods for measurement of the current perception threshold with the neurometer in rats and sensory nerve functions in animals, no studies have evaluated STZ-induced diabetic animals.…”

Section: Discussionmentioning

confidence: 99%

Transplantation of Bone Marrow–Derived Mesenchymal Stem Cells Improves Diabetic Polyneuropathy in Rats

et al. 2008

View full text Add to dashboard Cite

OBJECTIVE-Mesenchymal stem cells (MSCs) have been reported to secrete various cytokines that exhibit angiogenic and neurosupportive effects. This study was conducted to investigate the effects of MSC transplantation on diabetic polyneuropathy (DPN) in rats.RESEARCH DESIGN AND METHODS-MSCs were isolated from bone marrow of adult rats and transplanted into hind limb skeletal muscles of rats with an 8-week duration of streptozotocin (STZ)-induced diabetes or age-matched normal rats by unilateral intramuscular injection. Four weeks after transplantation, vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) productions in transplanted sites, current perception threshold, nerve conduction velocity (NCV), sciatic nerve blood flow (SNBF), capillary number-to-muscle fiber ratio in soleus muscles, and sural nerve morphometry were evaluated.RESULTS-VEGF and bFGF mRNA expression were significantly increased in MSC-injected thigh muscles of STZ-induced diabetic rats. Furthermore, colocalization of MSCs with VEGF and bFGF in the transplanted sites was confirmed. STZ-induced diabetic rats showed hypoalgesia, delayed NCV, decreased SNBF, and decreased capillary number-to-muscle fiber ratio in soleus muscles, which were all ameliorated by MSC transplantation. Sural nerve morphometry showed decreased axonal circularity in STZ-induced diabetic rats, which was normalized by MSC transplantation. D iabetic polyneuropathy (DPN) is the most common complication of diabetes. It is estimated that ϳ20 -30% of diabetic patients are affected by symptomatic DPN (1). Generally, DPN develops symmetrically in a length-dependent fashion, with dying back or dropout of the longest nerve fibers; both myelinated and unmyelinated, large and small are affected. Diabetic patients suffer from various symptoms of DPN, such as spontaneous pain, hyperalgesia, and diminished sensation (2). It has been shown that tight glycemic control is effective in slowing the progression of DPN but cannot completely prevent it (3). Therefore, additional therapeutic strategies are required. CONCLUSIONS-TheseNeural cell degeneration and decreased nerve blood flow (NBF) have been recognized as pathophysiologically characteristic features of DPN (4). Therefore, therapeutic agents that could act as both neurotrophic and angiogenic factors would be useful for the treatment of DPN even at an advanced stage. We previously demonstrated that local administration of basic fibroblast growth factor (bFGF) by intramusclar injection with crosslinked gelatin hydrogel improved the impaired nerve functions of streptozotocin (STZ)-induced diabetic rats, including amelioration of decreased NBF, hypoalgesia, and the delayed motor nerve conduction velocity (MNCV) on the treated side of sciatictibial nerves and that these effects were maintained for at least 30 days (5). Schratzberger et al. (6) showed that vascular endothelial growth factor (VEGF) gene transfer significantly increased the NCV and NBF as well as the vascular densities in muscle and peripheral nerv...

show abstract

Section: Discussionmentioning

confidence: 99%

Transplantation of Bone Marrow–Derived Mesenchymal Stem Cells Improves Diabetic Polyneuropathy in Rats

et al. 2008

View full text Add to dashboard Cite

show abstract

“…The CPT evaluation was performed at the 3 frequencies, 2000 Hz, 250 Hz and 5 Hz, corresponding to evaluation of the Aβ, Aδ and C fibers 7,8) . In theory, the effect of TENS on each of these 3 types of fibers should be different since they represent three different neurophysiological mechanisms of pain 2) .…”

Section: Discussionmentioning

confidence: 99%

“…A commonly used CPT device is the Neurometer NS3000 (Neurotron Inc., Baltimore, Maryland, USA) which employs a constant alternating sinusoidal current to deliver electrical stimulus at frequencies of 2000, 250 and 5 Hz 7) . It has been reported that these 3 frequencies can selectively stimulate, and therefore assess, the large myelinated Aβ fibers, the small myelinated Aδ fibers, and the unmyelinated C fibers, respectively 7,8) . Since CPT devices are usually constant current stimulators, skin impedance is not a limiting factor and the results are unaffected by skin temperature, skin thickness or elasticity 9) .…”

Section: Introductionmentioning

confidence: 99%

A Descriptive Study Investigating the Feasibility and Selectivity of Current Perception Threshold in the Objective Assessment of Post-operative Sub-acute Knee Pain

et al. 2013

View full text Add to dashboard Cite

Abstract.[Purpose] The aim of this study was to investigate the feasibility of using the current perception threshold (CPT), in a comparison with the visual analog scale (VAS), to assess its selectivity in assessing the excitability of Aβ, Aδ and C fibers in subjects with sub-acute post-operative pain who were being treated with conventional transcutaneous electrical nerve stimulation (TENS). [Subjects and Methods] A total of 17 subjects (mean age of 29.2 ±10.8 years) participated in this study. For all subjects, the study commenced on the fifth post-operative day and continued for the next five consecutive days following a descriptive time-series design. Both CPT and VAS were measured for all subjects on all five days following 15 minutes rest with the TENS output intensity set at zero on the baseline days (Days 1, 3, 5), and after 15 minutes TENS stimulation on the intervention days (Days 2 and 4).[Results] The results demonstrate that CPT was able to selectively assess the excitability of the Aβ and Aδ fibers. However, the selectivity of CPT in assessing the C fibers could not be verified in this study.[Conclusion] The various limitations of the time series design used in this study suggest the need to verify some of these results in a different experimental design in future studies.

show abstract

“…The Neurometer Ò (Neurotron, Inc., Baltimore, MD, USA) is an example of such a device; it has been used clinically to detect peripheral neuropathy in diabetic individuals. [1][2][3][4][5][6][7] By measuring CPT and CPT trends, transcutaneous nerve stimulation has been suggested as an effective tool in diagnosing and monitoring conditions associated with worsening peripheral neuropathy (i.e., increasing CPT values), such as diabetes mellitus or vibration-induced neuropathy. 2 Current standard techniques for determining nerve block effectiveness are limited by the inherent subjectivity of patient self-reporting (e.g., cold test, pinprick tests).…”

Section: Résumémentioning

confidence: 99%

Reproducibility of current perception threshold with the Neurometer® vs the Stimpod NMS450 peripheral nerve stimulator in healthy volunteers: an observational study

Tsui

Shakespeare

Leung

et al. 2013

Can J Anesth/J Can Anesth

View full text Add to dashboard Cite

Assessment of Peripheral Neuropathy Using Measurement of the Current Perception Threshold with the Neurometer® in Patients with Type 2 Diabetes Mellitus

Abstract: Measurement of current perception threshold (CPT) using the

Cited by 51 publications

References 29 publications

Transplantation of Bone Marrow–Derived Mesenchymal Stem Cells Improves Diabetic Polyneuropathy in Rats

Transplantation of Bone Marrow–Derived Mesenchymal Stem Cells Improves Diabetic Polyneuropathy in Rats

A Descriptive Study Investigating the Feasibility and Selectivity of Current Perception Threshold in the Objective Assessment of Post-operative Sub-acute Knee Pain

Reproducibility of current perception threshold with the Neurometer® vs the Stimpod NMS450 peripheral nerve stimulator in healthy volunteers: an observational study

Contact Info

Product

Resources

About