Assessment of Parylene C Thin Films for Heart Valve Tissue Engineering

Marei, Isra; Chester, Adrian H.; Ivan, Cristina; Prodromakis, Themis; Trantidou, Tatiana; Yacoub, Magdi H.

doi:10.1089/ten.tea.2014.0607

Cited by 13 publications

(6 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One of the most promising solutions to prevent implant corrosion is the use of polymer-based, surface-protective coatings; for practical purposes, these coatings should be easy to deposit, strongly adhere to an implant surface, be chemically inert in physiological environments, be biocompatible, and have suitable mechanical strength. One polymeric material meeting these criteria is parylene C (poly(chloro- para -xylene)), which has been applied in numerous medical applications, e.g., as a neural prosthesis coating and in cardiac devices. , Parylene C is a crystalline-amorphous composite, has a nonporous structure, and has a low permeability to small molecules. , While the chemical passivity of a parylene C coating determines its applicability as a protective, anti-corrosive layer, it is also problematic because hydrophobic surfaces do not support the growth of adhesive cells, e.g., osteoblasts. A parylene C surface can be successfully modified using oxygen plasma modification methods by introducing oxygen-containing functional groups and surface nanotopography .…”

Section: Introductionmentioning

confidence: 99%

“…One polymeric material meeting these criteria is parylene C (poly(chloro-para-xylene)), which has been applied in numerous medical applications, e.g., as a neural prosthesis coating and in cardiac devices. 7,8 Parylene C is a crystalline-amorphous composite, has a nonporous structure, and has a low permeability to small molecules. 9,10 While the chemical passivity of a parylene C coating determines its applicability as a protective, anti-corrosive layer, it is also problematic because hydrophobic surfaces do not support the growth of adhesive cells, e.g., osteoblasts.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Multifunctional PLGA/Parylene C Coating for Implant Materials: An Integral Approach for Biointerface Optimization

Gołda-Cępa

Chorylek

Chytrosz

et al. 2016

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

Functionalizing implant surfaces is critical for improving their performance. An integrated approach was employed to develop a multifunctional implant coating based on oxygen plasma-modified parylene C and drug-loaded, biodegradable poly(dl-lactide-co-glycolide) (PLGA). The key functional attributes of the coating (i.e., anti-corrosion, biocompatible, anti-infection, and therapeutic) were thoroughly characterized at each fabrication step by spectroscopic, microscopic, and biologic methods and at different scales, ranging from molecular, through the nano- and microscales to the macroscopic scale. The chemistry of each layer was demonstrated separately, and their mutual affinity was shown to be indispensable for the development of versatile coatings for implant applications.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Multifunctional PLGA/Parylene C Coating for Implant Materials: An Integral Approach for Biointerface Optimization

Gołda-Cępa

Chorylek

Chytrosz

et al. 2016

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

show abstract

“…These expansion data are supported with a finite element model that explores device deformation and relative stresses on a device under pneumatic pressure using a reference material (figs. S2 and S3) ( 30 ).…”

Section: Resultsmentioning

confidence: 99%

Electronics with shape actuation for minimally invasive spinal cord stimulation

Woodington

Curto

et al. 2021

Sci. Adv.

View full text Add to dashboard Cite

Spinal cord stimulation is one of the oldest and most established neuromodulation therapies. However, today, clinicians need to choose between bulky paddle-type devices, requiring invasive surgery under general anesthetic, and percutaneous lead–type devices, which can be implanted via simple needle puncture under local anesthetic but offer clinical drawbacks when compared with paddle devices. By applying photo- and soft lithography fabrication, we have developed a device that features thin, flexible electronics and integrated fluidic channels. This device can be rolled up into the shape of a standard percutaneous needle then implanted on the site of interest before being expanded in situ, unfurling into its paddle-type conformation. The device and implantation procedure have been validated in vitro and on human cadaver models. This device paves the way for shape-changing bioelectronic devices that offer a large footprint for sensing or stimulation but are implanted in patients percutaneously in a minimally invasive fashion.

show abstract

“…The pseudo-conformal nature of the Parylene-C deposition process ensures that all flow paths are coated with a non-reacting, non-water-adsorbing, biocompatible material [ 31 , 37 ]. This allows the pumping of fluids commonly used for infusions, including pharmaceuticals and biologic agents without altering the fluids or the pump.…”

Section: Resultsmentioning

confidence: 99%

“…Parylene-C has been shown to be biocompatible with in vitro studies including live/dead staining and cell viability [ 29 ], and in vivo tests for inflammation [ 30 ] and tissue morphologic changes [ 31 , 32 ]. Material structural stability when implanted has been confirmed with long-term in vivo studies [ 33 ].…”

Section: Designmentioning

confidence: 99%

Towards an Implantable, Low Flow Micropump That Uses No Power in the Blocked-Flow State

Johnson

Borkholder

2016

Micromachines

View full text Add to dashboard Cite

Low flow rate micropumps play an increasingly important role in drug therapy research. Infusions to small biological structures and lab-on-a-chip applications require ultra-low flow rates and will benefit from the ability to expend no power in the blocked-flow state. Here we present a planar micropump based on gallium phase-change actuation that leverages expansion during solidification to occlude the flow channel in the off-power state. The presented four chamber peristaltic micropump was fabricated with a combination of Micro Electro Mechanical System (MEMS) techniques and additive manufacturing direct write technologies. The device is 7 mm × 13 mm × 1 mm (<100 mm3) with the flow channel and exterior coated with biocompatible Parylene-C, critical for implantable applications. Controllable pump rates from 18 to 104 nL/min were demonstrated, with 11.1 ± 0.35 nL pumped per actuation at an efficiency of 11 mJ/nL. The normally-closed state of the gallium actuator prevents flow and diffusion between the pump and the biological system or lab-on-a-chip, without consuming power. This is especially important for implanted applications with periodic drug delivery regimens.

show abstract

Assessment of Parylene C Thin Films for Heart Valve Tissue Engineering

Abstract: PC is a promising candidate for use as a scaffold in tissue engineering heart valves. Additional studies are required to determine both the durability and long-term performance of cell-seeded PC when in a similar hemodynamic environment to that of the aortic valve.

Cited by 13 publications

References 30 publications

Multifunctional PLGA/Parylene C Coating for Implant Materials: An Integral Approach for Biointerface Optimization

Multifunctional PLGA/Parylene C Coating for Implant Materials: An Integral Approach for Biointerface Optimization

Electronics with shape actuation for minimally invasive spinal cord stimulation

Towards an Implantable, Low Flow Micropump That Uses No Power in the Blocked-Flow State

Contact Info

Product

Resources

About