Assessment of Paronychia Argentea Extraction on Kidney Stone by Using Calcium Oxalate Method

Abstract

Urinary calculi are stones (urolithiasis) that can form anywhere in urinary tract outside of the kidneys and mostly composed of calcium oxalate and phosphate, additionally with elevated throughout the last two decades in the world. Chemical composition plays a major part in nephrolithiasis. Therefore, the high concentrations of lithogenic substances in urine enhance the crystallization method in urine tract system. The most kidney stones form from calcium oxalate, the present study was inspected the effect of the crude aqueous extract as well as the fractionated methanol extract (ethyl acetate, isopropanol, acetone and methanol residue) of paronychia argentea on the crystallization of calcium oxalate salts. The effect of aqueous extract and fractionated methanol extract on the size, number, type of calcium oxalate crystals. Paronychia argentea both the crude aqueous and the fractionated extract, especially ethyl acetate fraction have antiurolithic activity via reducing crystal size as well as activate the formation of calcium oxalate dihydrate (COD) crystals out from calcium oxalate monohydrate (COM) with increasing concentration of extract. The shifting of crystallization process to producing calcium oxalate dihydrate (COD) rather than oxalate monohydrate (COM) and the reducing the crystal size and calcium ion concentration, in addition to the diuretic action of extract plays an important role in controlling urolithiasis.

Comparison of the Effects of Laparoscopic Surgery and Traditional Open Surgery on Stone Clearance, Laboratory Indexes and Life Quality in Patients with Renal Calculi

“…However, for intrarenal pyelolithiasis, staghorn calculi with multiple branches growing into different calyceal and multiple calyceal stones with secondary infundibulum stenosis or calyceal diverticulum, it is much more complicated, and laparoscopic pyelolithotomy alone may not be successful. Currently, intrarenal sinus peotomy or partial renal parenchyma incision becomes necessary [ 21 , 22 ].…”

Antioxidant and Anti-inflammatory Activities of Paronychia Argentea (Algerian Tea)

“…11,34 Last but not the least, several studies showed that the fractions of the total extract of this plant has high potency in treatment of kidney stones (calcium oxalate and calcium phosphate); mainly those fractions contains non-polar and semipolar compounds of this plant. 35,36…”