Assessment of oxytocin level, glucose metabolism components and cutoff values for oxytocin and anti-mullerian hormone in infertile PCOS women

Jahromi, Bahia Namavar; Dabbaghmanesh, Mohammad Hossein; P, Bakhshaie; Parsanezhad, Mohammad Ebrahim; Anvar, Zahra; Alborzi, Mahshid; Zarei, Afsoon; Bakhshaei, Mina

doi:10.1016/j.tjog.2018.06.015

Cited by 21 publications

(21 citation statements)

References 21 publications

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“…Which may be due to the reason that OT control metabolism and body weight by increasing energy expenditure, lipolysis and its effects on multiple homeostatic and neurobehavioral pathway [ 72 ]. In consistent with this study, [73] have reported that OT level was lower in the PCOS group in comparison to control and systemic administration of OT results ovary volume reduction, BW reduction and balance hormonal profile in women affected by PCOS. Therefore, it is evident that there had been decrease in the gonadal weight in the female treated with OT up to 90 days.…”

Section: Discussionsupporting

confidence: 89%

Effects of oxytocin and antagonist antidote atosiban on body weight and food intake of female mice, Mus musculus

Thakur

Shrivastava

2021

Metabolism Open

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Section: Discussionsupporting

confidence: 89%

Effects of oxytocin and antagonist antidote atosiban on body weight and food intake of female mice, Mus musculus

Thakur

Shrivastava

2021

Metabolism Open

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“…A previous study revealed that oxytocin showed negative correlation with FI and HOMA in obese women with polycystic ovary syndrome [31]. Another study showed that oxytocin concentration correlated negatively with glycated haemoglobin (HbA 1c ) and FPG in diabetic metabolic syndrome patients [32].…”

Section: Original Papermentioning

confidence: 98%

Associations of oxytocin with metabolic parameters in obese women of childbearing age

Kuang

Duan

et al. 2019

Endokrynologia Polska

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Introduction: The aim of this study was to compare plasma oxytocin levels in obese women of childbearing age with non-obese women of childbearing age, and to investigate the relationship between plasma oxytocin levels and metabolic parameters (including blood glucose, insulin resistance, blood lipid, and blood pressure). Material and methods: A total of 151 obese women of childbearing age and 160 non-obese women of childbearing age were enrolled in this study. Plasma oxytocin levels were measured by electrochemiluminescence immunoassays. Height, body weight, body mass index (BMI), fasting blood glucose (FBG), fasting insulin (FI), homeostasis model assessment for insulin resistance (HOMA-IR), total triglycerides (TG), total cholesterol (TC), low-density lipoprotein-C (LDL-C), high-density lipoprotein-C (HDL-C), systolic blood pressure (SBP), and diastolic blood pressure (DBP) were measured in all subjects. Quantile regression analysis was used to analyse the associations of plasma oxytocin levels with FBG, FI, HOMA-IR, TG, TC, LDL-C, HDL-C, SBP, and DBP. Results: In obese women of childbearing age, plasma oxytocin levels were lower compared with non-obese controls. After adjusting for age, quantile regression analysis showed that the plasma oxytocin levels were inversely associated with HOMA-IR at the quantile level between 0.27 and 0.79 (i.e. the HOMA-IR level of 2.11 and 3.07, respectively), the plasma oxytocin levels were inversely associated with TC after the quantile level of 0.21 (i.e. the TC level of 3.78), and the plasma oxytocin levels were inversely associated with LDL-C at all quantile levels of LDL-C. In addition, the plasma oxytocin levels showed a positive association with HDL-C at all quantile levels of HDL-C. No significant associations were found between the plasma oxytocin levels and FBG, FI, TG, SBP, and DBP. Conclusions: Oxytocin deficiency was common in obese women of childbearing age. Oxytocin showed negative correlation with HOMA-IR, TC, and LDL-C, while it showed positive association with HDL-C. Our findings suggest that oxytocin played an important role in inhibiting metabolic disorders associated with obesity in women of childbearing age.

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“…The dysfunction in these women is characterized by the arrest of follicle maturation and the disturbed selection of the dominant follicle, and an increased number of early antral follicles [44]. PCOS is often associated with obesity (38-66% PCOS patients), insulin resistance (IR), and decreased pregnancy rates in natural and assisted conception cycles [46]. However, it is debatable if IR is the consequence of PCOS or obesity itself [46].…”

Section: Polycystic Ovary Syndromementioning

confidence: 99%

“…PCOS is often associated with obesity (38-66% PCOS patients), insulin resistance (IR), and decreased pregnancy rates in natural and assisted conception cycles [46]. However, it is debatable if IR is the consequence of PCOS or obesity itself [46]. Ovarian aging and age at menopause could be delayed in women with PCOS [44].…”

Section: Polycystic Ovary Syndromementioning

confidence: 99%

The role of anti-Müllerian hormone (AMH) in ovarian disease and infertility

Bedenk

Vrtačnik-Bokal

Virant‐Klun

2019

J Assist Reprod Genet

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Purpose In this review, the current knowledge on anti-Müllerian hormone (AMH) is presented, concerning its value in disease and IVF treatment as well as in terms of its prospective clinical use. Methods AMH is becoming the most appropriate biomarker for the ovarian reserve measured predominantly for assisted reproductive treatment (ART) patients in comparison to the currently used antral follicle count (AFC). However, this is not the only way AMH measurements can be used in the clinics. Because of this, we reviewed the current literature for the use of AMH in current or prospective clinical practice. Results We found that AMH has a high predictive value in assessing the ovarian reserve, which can lead to a better efficiency of in vitro fertilization (IVF) procedures. It has a high potential to be developed as a staple diagnostic marker of ovarian disease, especially for ovarian cancers and even as a possible treatment tool for certain cancers. It could potentially be used to prevent oocyte loss due to chemo-or radiotherapy. Conclusion AMH is an important hormone especially in women reproductive organs and is currently seen as the best biomarker for a multitude of uses in reproductive medicine. Currently, the biggest issue lies in the lack of international standardization of AMH. However, it is encouraging to see that there is interest in AMH in the form of research on its action and use in reproductive medicine.

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Assessment of oxytocin level, glucose metabolism components and cutoff values for oxytocin and anti-mullerian hormone in infertile PCOS women

Abstract: The mean oxytocin level in the PCOS infertile women was lower than non-PCOS women. Oxytocin showed a significant reverse correlation with AMH and HOMA-IR.

Cited by 21 publications

References 21 publications

Effects of oxytocin and antagonist antidote atosiban on body weight and food intake of female mice, Mus musculus

Effects of oxytocin and antagonist antidote atosiban on body weight and food intake of female mice, Mus musculus

Associations of oxytocin with metabolic parameters in obese women of childbearing age

The role of anti-Müllerian hormone (AMH) in ovarian disease and infertility

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