Assessment of osteopenic women microarchitecture with and without osteoporotic fracture by TBS on a new generation bone densitometer

Colson, François; Winzenrieth, Renaud; Hans, Didier

doi:10.1016/j.jocd.2011.02.057

Cited by 8 publications

(6 citation statements)

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“…Previous studies have documented the value of the TBS in assessing fracture risk in postmenopausal women [14][15][16][17][18][19][20][21][22][23][24][25]. The value of TBS for assessing risk is both sizeable and independent of BMD, which makes sense given the increasing understanding of the importance of bone architecture in determining bone strength [1,[9][10][11]35].…”

Section: Discussionmentioning

confidence: 99%

“…The added value of the TBS in bone mineral densitometry for fracture risk assessment has been documented in cross-sectional and longitudinal studies [17][18][19][20][21][22][23][24][25]. The objective of the current study was to assess the sensitivity of TBS to detect change over time in a large cohort of treated versus untreated older women.…”

Section: Introductionmentioning

confidence: 99%

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Effects of anti-resorptive agents on trabecular bone score (TBS) in older women

Aubry‐Rozier

Hans

et al. 2012

Osteoporos Int

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of anti-resorptive agents on trabecular bone score (TBS) in older women

Aubry‐Rozier

Hans

et al. 2012

Osteoporos Int

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“…Most of the published research on TBS, to date, has been conducted in patients with presumed primary osteoporosis, or in whom risk factors for secondary osteoporosis were not considered in the analysis. In such studies, TBS has been shown to predict both current [55][56][57][58][59][60][61][62][63][64] and future/incident [65][66][67][68] fragility fractures. Additional studies have addressed the impact of efficacious therapies for osteoporosis on TBS measurements.…”

Section: Tbs Predictions Of Current and Future Fragility Fractures: Pmentioning

confidence: 99%

Utility of the trabecular bone score (TBS) in secondary osteoporosis

et al. 2014

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Altered bone micro-architecture is an important factor in accounting for fragility fractures. Until recently, it has not been possible to gain information about skeletal microstructure in a way that is clinically feasible. Bone biopsy is essentially a research tool. High-resolution peripheral Quantitative Computed Tomography, while non-invasive, is available only sparsely throughout the world. The trabecular bone score (TBS) is an imaging technology adapted directly from the Dual Energy X-Ray Absorptiometry (DXA) image of the lumbar spine. Thus, it is potentially readily and widely available. In recent years, a large number of studies have demonstrated that TBS is significantly associated with direct measurements of bone micro-architecture, predicts current and future fragility fractures in primary osteoporosis, and may be a useful adjunct to BMD for fracture detection and prediction. In this review, we summarize its potential utility in secondary causes of osteoporosis. In some situations, like glucocorticoid-induced osteoporosis and in diabetes mellitus, the TBS appears to out-perform DXA. It also has apparent value in numerous other disorders associated with diminished bone health, including primary hyperparathyroidism, androgen-deficiency, hormone-receptor positive breast cancer treatment, chronic kidney disease, hemochromatosis, and autoimmune disorders like rheumatoid arthritis. Further research is both needed and warranted to more clearly establish the role of TBS in these and other disorders that adversely affect bone.

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“…This added value of TBS has been further documented in cross-sectional, prospective and longitudinal studies (11)(12)(13)(14)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35). Indeed, TBS has been found: 1. to be lower in post-menopausal women with a past osteoporotic fracture compared with age-and BMD-matched women without fracture (11), 2. to give an incremental increase in the odds ratio for spine fracture when combined with spine BMD (12,(21)(22)(23)(24)(25), 3. to be lower in women with fractures compared with women without frac-…”

Section: Discussionmentioning

confidence: 76%

“…tures, irrespective of whether their BMD met the criteria for osteoporosis or osteopenia (13,(21)(22)(23)(24)(25), 4. to prospectively predict fracture as well as spine BMD (14,26,27), 5. to recapture around 1/3 of the patients who were miss-classified according to the BMD WHO definition of osteoporosis alone (21)(22)(23)(24)(25)(26)(27), and 6. to be responsive to treatment therapy (28)(29)(30)(31)(32).…”

Section: Resultsmentioning

confidence: 99%

The OsteoLaus Cohort Study

Krieg

Stoll²,

Aubry‐Rozier³

et al. 2012

Osteologie

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ZusammenfassungEine indirekte Beurteilung der Mikroarchitektur (MA) ist in der täglichen Praxis anhand des TBS (Trabecular Bone Score) näherungsweise möglich. Das Ziel der OsteoLaus-Kohorte besteht darin, klinische Risikofaktoren und Informationen aus der DXA (Knochenmineraldichte [BMD], TBS und Wirbelkörperfrakturerkennung [VFA]) zu kombinieren, um Frauen mit hohem Frakturrisiko leichter zu erkennen. Wir nahmen 631 Frauen im mittleren Alter von 67,4 ± 6,7 J. und mit einem BMI von 26,1 ± 4,6 auf. Es bestand eine schwache Korrelation zwischen BMD und Zentrums-gematchtem TBS (r2 = 0,16). Die Prävalenz von Wirbelfrakturen (VFx) Grad 2/3, größeren osteoporotischen (OP) Frakturen und allen OP-Frakturen betrug 8,4 %, 17,0 % bzw. 26,0 %. Alters- und BMI-adjustierte OR (nach abnehmender SD) lagen bei 1,8 (1,2–2,5), 1,6 (1,2–2,1) bzw. 1,3 (1,1–1,6) für BMD und 2,0 (1,4–3,0), 1,9 (1,4–2,5) bzw. 1,4 (1,1–1,7) für TBS. Die TBS OR (nach abnehmender SD), adjustiert nach Alter, BMI und Wirbelsäulen-BMD, für VFx Grad 2/3, größere und alle OP-Frakturen betrugen 1,7 (1,1–2,7), 1,6 (1,2–2,2) bzw. 1,3 (1,0–1,7). Nur 35 bis 44 % der Frauen mit OP-Frakturen hatten eine BMD <−2,5 SD oder einen TBS < 1.200. Durch Kombination eines BMD < −2,5 SD oder TBS < 1,200 werden 54 bis 60 % der Frauen mit OP-Fraktur erkannt. Somit können wir anhand von VFA, BMD und TBS aus einem einfachen und strahlenarmen Röntgenverfahren, der DXA, Zusatzinformationen gewinnen, die für den Patienten im Praxisalltag von Nutzen sind.

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Assessment of osteopenic women microarchitecture with and without osteoporotic fracture by TBS on a new generation bone densitometer

Cited by 8 publications

References 0 publications

Effects of anti-resorptive agents on trabecular bone score (TBS) in older women

Effects of anti-resorptive agents on trabecular bone score (TBS) in older women

Utility of the trabecular bone score (TBS) in secondary osteoporosis

The OsteoLaus Cohort Study

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