Assessment of organohalogenated pollutants in breast milk from the Czech Republic

Parizek, Ondrej; Gramblicka, Tomas; Parizkova, Denisa; Polachova, Andrea; Bechyňská, Kamila; Dvořáková, Darina; Stupák, Michal; Dusek, Jiri; Pavlikova, Jitka; Topinka, Jan; Srám, Radim J.; Pulkrabová, Jana

doi:10.1016/j.scitotenv.2023.161938

Cited by 12 publications

(10 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As an alternative or precursor, N-MeFOSAA could be transformed to PFOS but has been rarely studied to quantify in biosamples, which with relatively long perfluoroalkyl (C = 11) chains are of concern due to their tendency of bioaccumulation. Three studies analyzed N-MeFOSAA in human milk but without detection. − N-MeFOSAA was found to be the second most abundant PFAS in the locally produced bottled water in Bangkok, with the highest concentration of 11.02 ng/L . The high concentration of N-MeFOSAA in human milk in this study could be explained by the long-term exposure to drinking water containing this chemical or conversion from another precursor, N -methyl perfluorooctane sulfonamido ethanol (N-MeFOSE) .…”

Section: Results and Discussionmentioning

confidence: 68%

Changes in Concentrations of Polyfluoroalkyl Substances in Human Milk Over Lactation Time and Effects of Maternal Exposure via Analysis of Matched Samples

Zhang,

Zhou,

Chen

et al. 2024

Environ. Sci. Technol.

View full text Add to dashboard Cite

Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are potentially related to many adverse health outcomes and could be transferred from maternal blood to human milk, which is an important exposure source for infants during a longterm period. In this study, the maternal blood of 76 women after delivery and their matched human milk samples obtained at 0.5, 1, and 3 months were analyzed by solid-phase extraction method with metal−organic framework/polymer hybrid nanofibers as the sorbents and ultrahigh-performance liquid chromatography-negative electrospray ionization mass spectrometric for quantitative analysis of 31 PFAS. The perfluorooctanoic acid, perfluorooctane sulfonate, and N-methyl perfluorooctane sulfonamido acetic acid (N-MeFOSAA) contributed to more than approximately 50% of the total PFAS concentrations in blood and human milk, while N-MeFOSAA (median: 0.274 ng/mL) was the highest PFAS in human milk at 3 months. The transfer efficiencies for PFAS from maternal blood to human milk at 0.5 months were generally lower, with medians ranging from 0.20% to 16.9%. The number of PFAS species detected in human milk increased as the lactation time went on from 0.5 to 3 months, and the concentrations of 10 PFAS displayed an increasing trend as the prolongation of lactation time (p < 0.05).

show abstract

Section: Results and Discussionmentioning

confidence: 68%

Changes in Concentrations of Polyfluoroalkyl Substances in Human Milk Over Lactation Time and Effects of Maternal Exposure via Analysis of Matched Samples

Zhang,

Zhou,

Chen

et al. 2024

Environ. Sci. Technol.

View full text Add to dashboard Cite

show abstract

“…A study by Parizek et al. ( 2023 ) investigated organohalogenated pollutants in human milk from the Czech Republic, including 15 PCN congeners. PCN‐20, PCN‐52 and PCN‐66 were reported in < 1% of the samples (note that although the concentration was reported for PCN‐66, it was not clear that this had been resolved from PCN‐67).…”

Section: Assessmentmentioning

confidence: 99%

Risks for animal and human health related to the presence of polychlorinated naphthalenes (PCNs) in feed and food

Schrenk,

Bignami,

Bodin

et al. 2024

EFS2

View full text Add to dashboard Cite

EFSA was asked for a scientific opinion on the risks for animal and human health related to the presence of polychlorinated naphthalenes (PCNs) in feed and food. The assessment focused on hexaCNs due to very limited data on other PCN congeners. For hexaCNs in feed, 217 analytical results were used to estimate dietary exposures for food-producing and non-food-producing animals; however, a risk characterisation could not be performed because none of the toxicological studies allowed identification of reference points. The oral repeated dose toxicity studies performed in rats with a hexaCN mixture containing all 10 hexaCNs indicated that the critical target was the haematological system. A BMDL 20 of 0.05 mg/kg body weight (bw) per day was identified for a considerable decrease in the platelet count. For hexaCNs in food, 2317 analytical results were used to estimate dietary exposures across dietary surveys and age groups. The highest exposure ranged from 0.91 to 29.8 pg/kg bw per day in general population and from 220 to 559 pg/kg bw per day for breast-fed infants with the highest consumption of breast milk. Applying a margin of exposure (MOE) approach, the estimated MOEs for the high dietary exposures ranged from 1,700,000 to 55,000,000 for the general population and from 90,000 to 230,000 for breast-fed infants with the highest consumption of breast milk. These MOEs are far above the minimum MOE of 2000 that does not raise a health concern. Taking account of the uncertainties affecting the assessment, the Panel concluded with at least 99% certainty that dietary exposure to hexaCNs does not raise a health concern for any of the population groups considered. Due to major limitations in the available data, no assessment was possible for genotoxic effects or for health risks of PCNs other than hexaCNs.

show abstract

“…Organochlorines (OCs) can accumulate in children via breast milk, but they are expected to decline be lower in high income countries [5]. 12 ng/g) lipid weight [6] 0.002 µg/g bw/week (2 pg TEQ/kg bw/week, EU) [7] Endocrine disruption, cancer, effects on nervous system development, immunotoxicity [6].…”

Section: Pops Into Breast Milkmentioning

confidence: 99%

“…Perfluoroalkyl and polyfluoroalkyl substances (PFAS) PFOA, PFOS 0.022 µg/L, 0.021 µg/L respectively [6] 0.07 µg/L combined (70 ppt combined, PFOA + PFOS, EPA-Water) [8] Immune system effects, developmental delays, endocrine disruptions, fertility effects, increased risk of certain cancers [6].…”

Section: Pops Into Breast Milkmentioning

confidence: 99%

See 1 more Smart Citation

Pollutants in Breast Milk: A Scoping Review of the Most Recent Data in 2024

Serreau,

Terbeche,

Rigourd

2024

Healthcare

View full text Add to dashboard Cite

Perinatal exposure to pollutants, including persistent organic pollutants (POPs) and heavy metals, poses significant risks to both mothers and children, marking this period as highly vulnerable. Despite the well-acknowledged benefits of breastfeeding, there exists a gap in comprehensive understanding regarding the impact of environmental pollutants on breast milk, underscoring the critical need for this study. Our research addresses this gap by exploring the intersection of environmental health and lactation, situated within the broader ‘One Health’ concept, thus contributing a novel perspective to the existing body of knowledge. This scoping review aims to examine recent research on the persistent presence of organic pollutants (POPs) and heavy metals in breast milk, thereby elucidating the environmental setting’s impact on milk quality. We seek to highlight the innovative angle of our study by emphasizing the ‘One Health’ concept, which has not been thoroughly explored in the context of lactation and environmental pollutants. We performed a scoping review, consulting two online databases to identify articles published from 1995 to 2023 that reported on pollutants in breast milk, using the PRISMA checklist. This methodological approach underlines the comprehensive and up-to-date nature of our literature review, ensuring the relevance and timeliness of our findings. From a total of 54 relevant articles, findings indicate that POPs are present in higher concentrations in breast milk the longer the lactation period. These findings highlight the persistent and bioaccumulative nature of such contaminants, offering new insights into their long-term implications for maternal and infant health. This exposure does not appear time-sensitive, suggesting pollutants accumulated in maternal fat compartments can be excreted into human milk years after exposure, a novel finding that underscores the importance of considering long-term environmental exposures in lactation research. The presence of POPs and heavy metals in both infant formula and maternal milk underscores a critical need for further comparative studies to understand the health implications better. Our discussion extends the current dialogue on the safety of breastfeeding in polluted environments, providing a new framework for assessing risks and benefits. While breastfeeding remains the WHO-recommended nutrition for optimal infant growth, the findings emphasize the importance of continued risk reduction policies to protect mothers and infants from environmental contaminants in breast milk. Our conclusion calls for an integrated approach, combining public health, environmental science, and clinical practice to develop effective strategies for reducing exposure to environmental pollutants. This multidisciplinary perspective is a significant contribution to the field, paving the way for future research and policy development.

show abstract

Assessment of organohalogenated pollutants in breast milk from the Czech Republic

Cited by 12 publications

References 52 publications

Changes in Concentrations of Polyfluoroalkyl Substances in Human Milk Over Lactation Time and Effects of Maternal Exposure via Analysis of Matched Samples

Changes in Concentrations of Polyfluoroalkyl Substances in Human Milk Over Lactation Time and Effects of Maternal Exposure via Analysis of Matched Samples

Risks for animal and human health related to the presence of polychlorinated naphthalenes (PCNs) in feed and food

Pollutants in Breast Milk: A Scoping Review of the Most Recent Data in 2024

Contact Info

Product

Resources

About