Assessment of oral and overall health parameters using the SillHa Oral Wellness System

Adibi, Shawn S.; Hanson, Ryan; Fray, David; Abedi, Tania; Neil, Brianna; Maher, Danielle; Tribble, Gena D.; Warner, Ben F.; Farach-Carson, Mary C.

doi:10.1016/j.oooo.2022.02.007

Cited by 3 publications

(2 citation statements)

References 30 publications

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“…A previous study presented differential roles of innate and adaptive immunity in the incidence of dementia. Increased neutrophil and neutrophil-to-lymphocyte ratios are associated with higher dementia risk, whereas increased lymphocyte and lymphocyte-to-monocyte ratios are associated with lower dementia risk [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Digital oral health biomarkers for early detection of cognitive decline

Chung,

Chan

2023

BMC Public Health

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Background Oral health could influence cognitive function by stimulating brain activity and blood flow. The quantified oral status from oral inflammation, frailty and masticatory performance were rarely applied to the cognitive function screening. We aimed to adopt non-invasive digital biomarkers to quantify oral health and employ machine learning algorithms to detect cognitive decline in the community. Methods We conducted a prospective case-control study to recruit 196 participants between 50 and 80 years old from Puzi Hospital (Chiayi County, Taiwan) between December 01, 2021, and December 31, 2022, including 163 with normal cognitive function and 33 with cognitive decline. Demographics, daily interactions, electronically stored medical records, masticatory ability, plaque index, oral diadochokinesis (ODK), periodontal status, and digital oral health indicators were collected. Cognitive function was classified, and confirmed mild cognitive impairment diagnoses were used for sensitivity analysis. Results The cognitive decline group significantly differed in ODK rate (P = 0.003) and acidity from SILL-Ha (P = 0.04). Younger age, increased social interactions, fewer cariogenic bacteria, high leukocytes, and high buffering capacity led to lower risk of cognitive decline. Patients with slow ODK, high plaque index, variance of hue (VOH) from bicolor chewing gum, and acidity had increased risk of cognitive decline. The prediction model area under the curve was 0.86 and was 0.99 for the sensitivity analysis. Conclusions A digital oral health biomarker approach is feasible for tracing cognitive function. When maintaining oral hygiene and oral health, cognitive status can be assessed simultaneously and early monitoring of cognitive status can prevent disease burden in the future.

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Section: Discussionmentioning

confidence: 99%

Digital oral health biomarkers for early detection of cognitive decline

Chung,

Chan

2023

BMC Public Health

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“…This device does not measure the density directly; rather, it measures the color tone of the material as the rate of reflection by reflectance photometry. It has been shown that the magnitude of this measured value (reflectance, %) is strongly correlated with the magnitude of the actual measured value [ 31 ]. The measurement was performed by having the patients rinse their mouths with 30 ml of distilled water for 10 s, sucking the liquid with a dedicated dropper, and dropping 1 mL onto exclusive test papers for analysis.…”

Section: Ethicsmentioning

confidence: 99%

Benefits of basil tea for patients with differentiated thyroid cancer during radioiodine therapy: A randomized controlled trial

Nomura,

Nakayama,

Okizaki

2023

Heliyon

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Salivary leukocyte esterase activity by SillHa is a risk indicator of periodontal disease

et al. 2023

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Background There is increasing evidence that diagnostic salivary tests measuring inflammatory biomarkers are being developed to assess inflammatory status for early detection, prevention, and progression of periodontal disease. Therefore, the aim of the present study was to investigate and identify the salivary biomarker that can predict the inflammatory status of periodontal disease. Methods A total of 36 patients (28 women and 8 men) with an average age of 57 years were investigated. Unstimulated saliva was collected from the recruited subjects and analyzed using SillHa, a saliva-testing device that measures bacteria count, saliva buffer capacity, acidity, leukocyte esterase, protein, and ammonia. Periodontal parameters were then obtained by clinical examination and initial periodontal therapy was performed. Data obtained with SillHa were compared with clinical periodontal parameters at baseline, re-examination (three months from baseline), and final examination (six months from re-examination). Results Leukocyte esterase activity in saliva measured by SillHa; BOP and PCR measured by clinical examination showed a significant difference between baseline and final examination and between re-examination and final examination. Patients in the lower median group (group 1) had a significant difference in leukocyte esterase activity between baseline and final examination and re-examination and final examination. In addition, patients in Group 1 had significantly lower BOP between baseline and final examination. While patients in the higher median group (group 2) showed a modest decrease in leukocyte esterase activity, which was significant only between baseline and final examination, no significant changes were observed concerning BOP. Furthermore, the associated systemic disease was observed in 30% and 81.2% of group 1 and 2 patients, respectively. Conclusion The results suggest that leukocyte esterase activity in saliva measured by SillHa could serve as a reliable diagnostic marker for monitoring inflammatory status in periodontal disease.

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Assessment of oral and overall health parameters using the SillHa Oral Wellness System

Cited by 3 publications

References 30 publications

Digital oral health biomarkers for early detection of cognitive decline

Digital oral health biomarkers for early detection of cognitive decline

Benefits of basil tea for patients with differentiated thyroid cancer during radioiodine therapy: A randomized controlled trial

Salivary leukocyte esterase activity by SillHa is a risk indicator of periodontal disease

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