Assessment of Nonradioactive Multispectral Optoacoustic Tomographic Imaging With Conventional Lymphoscintigraphic Imaging for Sentinel Lymph Node Biopsy in Melanoma

Stoffels, Ingo; Jansen, Philipp; Petri, Maximilian; Goerdt, Lukas; Brinker, Titus J.; Griewank, Klaus G.; Poeppel, Thorsten D.; Schadendorf, Dirk; Klode, Joachim

doi:10.1001/jamanetworkopen.2019.9020

Cited by 28 publications

(29 citation statements)

References 64 publications

(118 reference statements)

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“…The appropriate treatment for inguinal metastatic melanoma has gained increasing interest in recent years. Contemporary research with the use of multispectral optoacoustic tomographic imaging may allow the nonradioactive detection of sentinel lymph nodes and thereby eventually replace the SLNB [ 36 ]. Other recent developments in the treatment of inguinal metastatic melanoma concern adjuvant immunotherapy and molecular targeted therapy [ 37 , 38 , 39 , 40 ].…”

Section: Discussionmentioning

confidence: 99%

One-Year Morbidity Following Videoscopic Inguinal Lymphadenectomy for Stage III Melanoma

Jansen

Vrielink

Faut

et al. 2021

Cancers

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Purpose: We aimed to elucidate morbidity following videoscopic inguinal lymphadenectomy for stage III melanoma. Methods: Melanoma patients who underwent a videoscopic inguinal lymphadenectomy between November 2015 and May 2019 were included. The measured outcomes were lymphedema and quality of life. Patients were reviewed one day prior to surgery and postoperatively every 3 months for one year. Results: A total number of 34 patients were included for participation; 19 (55.9%) patients underwent a concomitant iliac lymphadenectomy. Lymphedema incidence was 40% at 3 months and 50% at 12 months after surgery. Mean interlimb volume difference increased steadily from 1.8% at baseline to 6.9% at 12 months (p = 0.041). Median Lymph-ICF-LL total score increased from 0.0 at baseline to 12.0 at 3 months, and declined to 8.5 at 12 months (p = 0.007). Twelve months after surgery, Lymph-ICF-LL scores were higher for females (p = 0.021) and patients that received adjuvant radiotherapy (p = 0.013). The Median Distress Thermometer and EORTC QLQ-C30 summary score recovered to baseline at 12 months postoperatively (p = 0.747 and p = 0.203, respectively). Conclusions: The onset of lymphedema is rapid and continues to increase up to one year after videoscopic inguinal lymphadenectomy. Quality of life recovers to the baseline value.

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Section: Discussionmentioning

confidence: 99%

One-Year Morbidity Following Videoscopic Inguinal Lymphadenectomy for Stage III Melanoma

Jansen

Vrielink

Faut

et al. 2021

Cancers

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“…The concordance rate of ICG-labeled and technetium 99-marked detection of sentinel lymph node basins was 94.6% (106 of 112). Intraoperatively, 159 sentinel lymph nodes were detected using a NIR camera, and 165 were detected by using a gamma probe, resulting in a concordance rate of 96.4% (79). Routine use of MSOT in the clinic for diagnosis and management of melanomas will be beneficial (80).…”

Section: Dermatologic Imagingmentioning

confidence: 99%

Development of Multispectral Optoacoustic Tomography as a Clinically Translatable Modality for Cancer Imaging

MacCuaig

Jones

Abeyakoon

et al. 2020

Radiology: Imaging Cancer

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The use of optoacoustic imaging takes advantage of the photoacoustic effect to generate high-contrast, high-resolution medical images at penetration depths of up to 5 cm. Multispectral optoacoustic tomography (MSOT) is a type of optoacoustic imaging system that has seen promising preclinical success with a recent emergence into the clinic. Multiwavelength illumination of tissue allows for the mapping of multiple chromophores, which are generated endogenously or exogenously. However, translation of MSOT to the clinic is still in its preliminary stages. For successful translation, MSOT requires refinement of probes and data-acquisition systems to tailor to the human body, along with more intuitive, real-time visualization settings. The possibilities of optoacoustic imaging, namely MSOT, in the clinic are reviewed here.

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“…In near-filed applications such as non-melanoma skin cancers MSOT already successfully distinguished skin cancer from normal skin, being helpful for the visualization of lesion margins [13,14]. Even the detection of metastatic spread of melanoma to sentinel lymph nodes appears to be improved with MSOT when compared to current sentinel lymph node excision protocols [25,26]. Further, it was demonstrated that the injection of indocyanine green (ICG) and the detection via MSOT could be a proper replacement strategy for scintigraphy approaches [26].…”

Section: Current Clinical Applicationsmentioning

confidence: 99%

Shedding light on pediatric diseases: multispectral optoacoustic tomography at the doorway to clinical applications

et al. 2020

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Optoacoustic imaging (OAI), or photoacoustic imaging (PAI), has fundamentally influenced basic science by providing high-resolution visualization of biological mechanisms. With the introduction of multispectral optoacoustic tomography (MSOT), these technologies have now moved closer to clinical applications. MSOT utilizes short-pulsed near-infrared laser light to induce thermoelastic expansion in targeted tissues. This results in acoustic pressure waves, which are used to resolve specific endo-and exogenous chromophores. Especially in the pediatric population, this non-invasive imaging approach might hold fundamental advantages compared to conventional cross-sectional imaging modalities. As this technology allows the visualization of quantitative molecular tissue composition at high spatial resolution non-invasively in sufficient penetration depth, it paves the way to personalized medicine in pediatric diseases.

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Assessment of Nonradioactive Multispectral Optoacoustic Tomographic Imaging With Conventional Lymphoscintigraphic Imaging for Sentinel Lymph Node Biopsy in Melanoma

Cited by 28 publications

References 64 publications

One-Year Morbidity Following Videoscopic Inguinal Lymphadenectomy for Stage III Melanoma

One-Year Morbidity Following Videoscopic Inguinal Lymphadenectomy for Stage III Melanoma

Development of Multispectral Optoacoustic Tomography as a Clinically Translatable Modality for Cancer Imaging

Shedding light on pediatric diseases: multispectral optoacoustic tomography at the doorway to clinical applications

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