Assessment of Noninvasive Positive Pressure Ventilation in Healthy Young Volunteers Using Salivary Stress Biomarkers

Abstract

Aim: We performed a stress assessment of noninvasive positive pressure ventilation (NPPV) using the salivary biomarkers chromogranin A. Materials & methods: Twenty healthy volunteers were subjected to NPPV for 30 min. We collected saliva samples before and after NPPV and evaluated chromogranin A. Results: We collected saliva samples from 13 volunteers for enzyme measurement. Of the 13 volunteers, 11 showed elevated chromogranin A levels, which were significantly higher after NPPV than before NPPV (p < 0.01). The chromogranin A increase group displayed significantly increased leak flow and reduced respiratory rate and absolute humidity compared with the chromogranin A reduction group. Conclusion: The increase of leak volume might be a stress factor in patients receiving NPPV.

Study of the Effects of Recognition of Stress on Symptoms and Regular Hospital Visits: An Analysis from Japanese National Statistics

“…Because of limits to the number of options, insomnia, which has been identified as having a relationship to stress [ 26 ], was not included among the options for symptoms. A more objective method for the evaluation of stress is to obtain samples of saliva and blood, and to examine these for stress markers [ 27 , 28 , 29 ]. However, from the standpoint of simplicity and economy, this method cannot easily be used in a large-scale survey.…”