Assessment of Nonalcoholic Fatty Liver Disease Symptoms and Gut–Liver Axis Status in Zebrafish after Exposure to Polystyrene Microplastics and Oxytetracycline, Alone and in Combination

Zhou, Weicheng; Shi, Wei; Du, Xueying; Han, Yu; Tang, Yu; Ri, Sanghyok; Ju, Kwangjin; Kim, Tongchol; Huang, Lin; Zhang, Weixia; Yu, Yihan; Tian, Dandan; Yu, Yingying; Chen, Liangbiao; Wu, Zhichao; Liu, Guangxu

doi:10.1289/ehp11600

Cited by 41 publications

(8 citation statements)

References 106 publications

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“…This can be one of the reasons for NAFLD occurrence. 133 Prenatal exposure to high-fat diet combined with exposure to microplastics can be associated with NAFLD development. 134 It is interesting to note that not only ingested but also inhaled microplastics can be a threat to hepatic health by mostly unknown mechanisms.…”

Section: Microplasticsmentioning

confidence: 99%

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Plastic compounds and liver diseases: Whether bisphenol A is the only culprit

Sangwan,

Bhattacharyya,

Banerjee

2024

Liver International

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Plastics, while providing modern conveniences, have become an inescapable source of global concern due to their role in environmental pollution. Particularly, the focus on bisphenol A (BPA) reveals its biohazardous nature and association with liver issues, specifically steatosis. However, research indicates that BPA is just one facet of the problem, as other bisphenol analogues, microplastics, nanoplastics and additional plastic derivatives also pose potential risks. Notably, BPA is implicated in every stage of non‐alcoholic fatty liver disease (NAFLD) onset and progression, surpassing hepatitis B virus as a primary cause of chronic liver disease worldwide. As plastic contamination tops the environmental contaminants list, urgent action is needed to assess causative factors and mitigate their impact. This review delves into the molecular disruptions linking plastic pollutant exposure to liver diseases, emphasizing the broader connection between plastics and the rising prevalence of NAFLD.

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Section: Microplasticsmentioning

confidence: 99%

“…Exposure to polystyrene microplastics caused increase in LPS (lipopolysaccharide) in animal model. This can be one of the reasons for NAFLD occurrence 133 . Prenatal exposure to high‐fat diet combined with exposure to microplastics can be associated with NAFLD development 134 .…”

Section: Macro Micro Nanoplastics Induced Liver Toxicitymentioning

confidence: 99%

Plastic compounds and liver diseases: Whether bisphenol A is the only culprit

Sangwan,

Bhattacharyya,

Banerjee

2024

Liver International

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“…3,4 In addition, dietary composition, such as fructose and polyunsaturated or monounsaturated fats, could promote NAFLD by altering the gut microbiota, increasing intestinal permeability and elevating hepatic inflammation and lipid peroxidation. 5 Interestingly, several environmental pollutants, such as organochlorine pesticides, 6 polyfluoroalkyl substances, 7 and microplastics, 8 have been shown to alter lipid influx–efflux balance in the liver and promote hepatic inflammation, steatosis and NAFLD. However, the potential toxicity of many food additives known to be associated with the development of NAFLD, such as preservatives, remains unknown.…”

Section: Introductionmentioning

confidence: 99%

Chronic exposure to parabens promotes non-alcoholic fatty liver disease in association with the changes of the gut microbiota and lipid metabolism

Ren,

Shi,

et al. 2024

Food Funct.

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“…However, the toxicity of POPs meditated by engineered particles to aquatic emerging insects is largely unknown. Microplastics (MPs, 100 nm–5 mm) and nanoplastics (NPs, <100 nm) are typical charged engineered particles in freshwater environments that affect the bioavailability of POPs due to their strong adsorption capacities. , Perfluoroalkyl acid alternatives, emerging ionizable organic chemicals, often carry negative charges in the environment, and their environmental behaviors (such as sorption, desorption, and migration) can be affected by engineered particles due to charge-driven interactions, thereby affecting their bioavailability. The larvae of aquatic insects mainly stay in sediments and can accumulate exogenous contaminants through ingestion, thereby posing threaten to larval gut.…”

Section: Introductionmentioning

confidence: 99%

Nanoplastics Affect the Bioaccumulation and Gut Toxicity of Emerging Perfluoroalkyl Acid Alternatives to Aquatic Insects (Chironomus kiinensis): Importance of Plastic Surface Charge

Zhang,

Xia,

et al. 2024

ACS Nano

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Persistent organic pollutants (POPs) have been widely suggested as contributors to the aquatic insect biomass decline, and their bioavailability is affected by engineered particles. However, the toxicity effects of emerging ionizable POPs mediated by differentially charged engineered nanoparticles on aquatic insects are unknown. In this study, 6:2 chlorinated polyfluoroalkyl ether sulfonate (F-53B, an emerging perfluoroalkyl acid alternative) was selected as a model emerging ionizable POP; the effect of differentially charged nanoplastics (NPs, 50 nm, 0.5 g/kg) on F-53B bioaccumulation and gut toxicity to Chironomus kiinensis were investigated through histopathology, biochemical index, and gut microbiota analysis. The results showed that when the dissolved concentration of F-53B remained constant, the presence of NPs enhanced the adverse effects on larval growth, emergence, gut oxidative stress and inflammation induced by F-53B, and the enhancement caused by positively charged NP-associated F-53B was stronger than that caused by the negatively charged one. This was mainly because positively charged NPs, due to their greater adsorption capacity and higher bioavailable fraction of associated F-53B, increased the bioaccumulation of F-53B in larvae more significantly than negatively charged NPs. In addition, positively charged NPs interact more easily with gut biomembranes and microbes with a negative charge, further increasing the probability of F-53B interacting with gut biomembranes and microbiota and thereby aggravating gut damage and key microbial dysbacteriosis related to gut health. These findings demonstrate that the surface charge of NPs can regulate the bioaccumulation and toxicity of ionizable POPs to aquatic insects.

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Assessment of Nonalcoholic Fatty Liver Disease Symptoms and Gut–Liver Axis Status in Zebrafish after Exposure to Polystyrene Microplastics and Oxytetracycline, Alone and in Combination

Cited by 41 publications

References 106 publications

Plastic compounds and liver diseases: Whether bisphenol A is the only culprit

Plastic compounds and liver diseases: Whether bisphenol A is the only culprit

Chronic exposure to parabens promotes non-alcoholic fatty liver disease in association with the changes of the gut microbiota and lipid metabolism

Nanoplastics Affect the Bioaccumulation and Gut Toxicity of Emerging Perfluoroalkyl Acid Alternatives to Aquatic Insects (Chironomus kiinensis): Importance of Plastic Surface Charge

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