Assessment of nickel oxide substituted bioactive glass-ceramic on in vitro bioactivity and mechanical properties

Vyas, Vikash Kumar; Kumar, Ankush; Ali, Akher; Prasad, S. K.; Srivastava, Pradeep; Mallick, Sarada Prasanna; Ershad,; Singh, Shailendra; Pyare, Ram

doi:10.1016/j.bsecv.2016.09.005

Cited by 35 publications

(12 citation statements)

References 36 publications

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“…Nickel has been incorporated in BGs to improve properties related to radiation attenuation and bone regeneration [ 307 – 312 ]. Vyas et al [ 313 – 315 ] developed 45S5 BG and 45S5 BG-ceramic (BGC) doped with NiO at different concentrations ranging from 0.41 to 1.65 mol% via the melt-quenching route. Compared to Ni-free 45S5 BGCs, an increase in density and mechanical properties such as microhardness, compressive, and flexural strength was observed with increasing NiO concentration [ 313 , 315 ].…”

Section: Bioactive Glasses Doped With Other Elementsmentioning

confidence: 99%

“…Vyas et al [ 313 – 315 ] developed 45S5 BG and 45S5 BG-ceramic (BGC) doped with NiO at different concentrations ranging from 0.41 to 1.65 mol% via the melt-quenching route. Compared to Ni-free 45S5 BGCs, an increase in density and mechanical properties such as microhardness, compressive, and flexural strength was observed with increasing NiO concentration [ 313 , 315 ]. The incorporation of Ni did not have an effect on the amorphous structure of 45S5 BG, as well as no additional crystalline phases were observed for the glass-ceramics with nickel, which exhibited crystalline species characteristic of sodium calcium silicate (Na 2 Ca 2 Si 3 O 9 and Na 2 CaSi 3 O 8 ).…”

Section: Bioactive Glasses Doped With Other Elementsmentioning

confidence: 99%

“…The incorporation of Ni did not have an effect on the amorphous structure of 45S5 BG, as well as no additional crystalline phases were observed for the glass-ceramics with nickel, which exhibited crystalline species characteristic of sodium calcium silicate (Na 2 Ca 2 Si 3 O 9 and Na 2 CaSi 3 O 8 ). Furthermore, it was reported that the presence of Ni did not influence the bioactive behavior of all tested systems that showed apatite formation after 1 day of immersion in SBF [ 313 , 315 ]. The cytotoxicity of Ni-doped 45S5 BGs to rabbit derived-osteoblast cells was directly tested.…”

Section: Bioactive Glasses Doped With Other Elementsmentioning

confidence: 99%

“…The cytotoxicity of Ni-doped 45S5 BGs to rabbit derived-osteoblast cells was directly tested. An MTT study revealed that Ni-45S5 BGCs (0–1.65 mol%) did not show cytotoxic behavior, resulting in higher cell proliferation at 0.82 NiO mol% [ 313 ].…”

Section: Bioactive Glasses Doped With Other Elementsmentioning

confidence: 99%

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Bioactive glasses incorporating less-common ions to improve biological and physical properties

Pantulap

Arango‐Ospina

Boccaccını

2021

J Mater Sci: Mater Med

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Bioactive glasses (BGs) have been a focus of research for over five decades for several biomedical applications. Although their use in bone substitution and bone tissue regeneration has gained important attention, recent developments have also seen the expansion of BG applications to the field of soft tissue engineering. Hard and soft tissue repair therapies can benefit from the biological activity of metallic ions released from BGs. These metallic ions are incorporated in the BG network not only for their biological therapeutic effects but also in many cases for influencing the structure and processability of the glass and to impart extra functional properties. The “classical” elements in silicate BG compositions are silicon (Si), phosphorous (P), calcium (Ca), sodium (Na), and potassium (K). In addition, other well-recognized biologically active ions have been incorporated in BGs to provide osteogenic, angiogenic, anti-inflammatory, and antibacterial effects such as zinc (Zn), magnesium (Mg), silver (Ag), strontium (Sr), gallium (Ga), fluorine (F), iron (Fe), cobalt (Co), boron (B), lithium (Li), titanium (Ti), and copper (Cu). More recently, rare earth and other elements considered less common or, some of them, even “exotic” for biomedical applications, have found room as doping elements in BGs to enhance their biological and physical properties. For example, barium (Ba), bismuth (Bi), chlorine (Cl), chromium (Cr), dysprosium (Dy), europium (Eu), gadolinium (Gd), ytterbium (Yb), thulium (Tm), germanium (Ge), gold (Au), holmium (Ho), iodine (I), lanthanum (La), manganese (Mn), molybdenum (Mo), nickel (Ni), niobium (Nb), nitrogen (N), palladium (Pd), rubidium (Rb), samarium (Sm), selenium (Se), tantalum (Ta), tellurium (Te), terbium (Tb), erbium (Er), tin (Sn), tungsten (W), vanadium (V), yttrium (Y) as well as zirconium (Zr) have been included in BGs. These ions have been found to be particularly interesting for enhancing the biological performance of doped BGs in novel compositions for tissue repair (both hard and soft tissue) and for providing, in some cases, extra functionalities to the BG, for example fluorescence, luminescence, radiation shielding, anti-inflammatory, and antibacterial properties. This review summarizes the influence of incorporating such less-common elements in BGs with focus on tissue engineering applications, usually exploiting the bioactivity of the BG in combination with other functional properties imparted by the presence of the added elements.

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Section: Bioactive Glasses Doped With Other Elementsmentioning

confidence: 99%

Section: Bioactive Glasses Doped With Other Elementsmentioning

confidence: 99%

Section: Bioactive Glasses Doped With Other Elementsmentioning

confidence: 99%

Section: Bioactive Glasses Doped With Other Elementsmentioning

confidence: 99%

See 2 more Smart Citations

Bioactive glasses incorporating less-common ions to improve biological and physical properties

Pantulap

Arango‐Ospina

Boccaccını

2021

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“…However, ceramic biomaterials, particularly bioactive glasses have been performing very well since its discovery, and therefore, considered as the best synthetic grafting material by far [12][13][14] for hard-tissue engineering applications apart from Autografts and Allograft (the gold standard for bone grafts). 15,16 Bioactive glasses discovered by prof. L.L.…”

mentioning

confidence: 99%

Bioactive ZnO‐assisted 1393 glass scaffold promotes osteogenic differentiation: Some studies

et al. 2022

Self Cite

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We developed ZnO‐assisted 1393 bioactive glass‐based scaffold with suitable mechanical properties through foam replica technique and observed to be suitable for bone tissue engineering application. However, the developed scaffolds' ability to facilitate cellular infiltration and integration was further assessed through in vivo studies in suitable animal model. Herein, the pure 1393 bioactive glass (BG) and ZnO‐assisted 1393 bioactive glass‐ (ZnBGs; 1, 2, 4 mol% ZnO substitution for SiO2 in pure BG is named as Z1BG, Z2BG, Z3BG, respectively) based scaffolds were prepared through sol–gel route, followed by foam replica techniques and characterized by a series of in vitro and some in vivo tests. Different cell lines like normal mouse embryonic cells (NIH/3T3), mouse bone marrow stromal cells (mBMSc), peripheral blood mononuclear cells, that is, lymphocytes and monocytes (PBMC) and U2OS (carcinogenic human osteosarcoma cells) were used in determination and comparative analysis of the biological compatibility of the BG and ZnBGs. Also, the alkaline phosphatase (ALP) activity, and osteogenic gene expression by primer‐specific osteopontin (OPN), osteocalcin (OCN), and glyceraldehyde‐3‐phosphate dehydrogenase (GAPDH) genes were performed to study osteogenic differentiability of the stromal cells in different BGs. Moreover, radiological and histopathological tests were performed in bone defect model of Wister rats to evaluate the in vivo bone regeneration and healing. Interestingly, these studies demonstrate augmented biological compatibility, and superior osteogenic differentiation in ZnBGs, in particular Z3BG than the pure BG in most cases.

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Evaluation of tensile, thermal, and biological properties of natural rubber‐based biocomposite with biosilicate and 45S5‐K bioglass

Lima

Caetano

Soares

et al. 2023

J of Applied Polymer Sci

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The objective of this work was to develop new NR‐based biocomposite containing BioS and/or BL0 particles, which exhibit better tensile response, biocompatibility, and bioactivity for biomedical applications. Morphological, tensile, thermal, and biological tests were performed on the biocomposites to evaluate the influence of BioS and BL0 particles on the properties of the NR matrix. According to TG/DTG tests, the decomposition profiles of the NR/BioS and NR/BL0 biocomposites were similar to those of NR, whose main event could be seen in the 290–450°C temperature range, indicative of NR's structural degradation. Tensile analysis demonstrated that the addition of BioS or BL0 to the NR‐based biocomposite improved the elastic modulus and the tensile strength at break (σat break) in comparison to NR. The σat break value of the NR matrix increased from 0.99 ± 0.06 MPa to 1.84 ± 0.09 and 2.29 ± 0.04 MPa for the NR/BioS and NR/BL0 specimens with 30 wt%. Indirect cytotoxicity testing revealed that NR, NR/BL0, and NR/BioS biocomposite specimens promote the attachment of MSCs cell, that is, greater than 70% viability as defined in ISO 10993‐5:2009. The results indicate that BioS and BL0 particles have improved the tensile response and biological properties of the NR matrix, resulting in a range of potential biomedical applications.

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Assessment of nickel oxide substituted bioactive glass-ceramic on in vitro bioactivity and mechanical properties

Cited by 35 publications

References 36 publications

Bioactive glasses incorporating less-common ions to improve biological and physical properties

Bioactive glasses incorporating less-common ions to improve biological and physical properties

Bioactive ZnO‐assisted 1393 glass scaffold promotes osteogenic differentiation: Some studies

Evaluation of tensile, thermal, and biological properties of natural rubber‐based biocomposite with biosilicate and 45S5‐K bioglass

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