Assessment of neuroprotective properties of Rhus coriaria L. ethanol extract in an in vitro model of retinal degeneration

Khalilpour, Saba; Behnammanesh, Ghazaleh; Majid, Amin Malik Shah Abdul; Tamayol, Ali; Majid, Aman Shah Abdul

doi:10.1016/j.hermed.2017.06.001

Cited by 11 publications

(14 citation statements)

References 34 publications

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“…The collected fruits were cleaned and dried at 35 °C for 24 h. To prepare the extract by the maceration process, powder form of the dried herb was added to ethanol and subjected to maceration [ 5 ]. The mixture of herb and solvent was placed in a shaker for 48 h at room temperature to be mixed gently using a magnetic stirrer.…”

Section: Methodsmentioning

confidence: 99%

“…Oxidative stress is believed to play a major part in the pathogenesis of optic neuropathy [ 1 ]. Apoptosis, or programmed cell death, is a method of cell loss during ischemia [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…Cathepsins constitute a family of proteases and inflammatory response mediators that are associated with regulation of a type of cell death called caspase-dependent cell apoptosis [ 2 , 3 ]. They have been shown to be a key initiator of apoptosis by directly activating caspases [ 5 , 6 ]. Induction of an inflammatory response by reperfusion following ischemic tissue injury may increase the intensity of damage [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…Linoleic, gallic, oleic, palmitic, and stearic acids are the major components that have been identified in the fruits of this herb in previous studies [ 12 ]. The role of R. coriaria as antidiarrheal, anti-indigestion, anti-anorexia, antihemorrhagic, hyperglycemic, atheroprotective and neuroprotective, properties have been previously assessed by in vitro and in vivo studies [ 5 , 12 ]. In the present study, we evaluated the neuroprotective action of R. coriaria in an in vivo model of ION.…”

Section: Introductionmentioning

confidence: 99%

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Neuroprotective and Anti-Inflammatory Effects of Rhus coriaria Extract in a Mouse Model of Ischemic Optic Neuropathy

et al. 2018

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Modulating oxidative stresses and inflammation can potentially prevent or alleviate the pathological conditions of diseases associated with the nervous system, including ischemic optic neuropathy. In this study we evaluated the anti-neuroinflammatory and neuroprotective activities of Rhus coriaria (R. coriaria) extract in vivo. The half maximal inhibitory concentration (IC50) for DPPH, ABTS and β–carotene were 6.79 ± 0.009 µg/mL, 10.94 ± 0.09 µg/mL, and 6.25 ± 0.06 µg/mL, respectively. Retinal ischemia was induced by optic nerve crush injury in albino Balb/c mice. The anti-inflammatory activity of ethanolic extract of R. coriaria (ERC) and linoleic acid (LA) on ocular ischemia was monitored using Fluorescence Molecular Tomography (FMT). Following optic nerve crush injury, the mice treated with 400 mg/kg of ERC and LA exhibited an 84.87% and 86.71% reduction of fluorescent signal (cathepsin activity) respectively. The results of this study provide strong scientific evidence for the neuroprotective activity of the ERC, identifying LA as one of the main components responsible for the effect. ERC may be useful and worthy of further development for its adjunctive utilization in the treatment of optic neuropathy.

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Section: Methodsmentioning

confidence: 99%

“…Oxidative stress is believed to play a major part in the pathogenesis of optic neuropathy [ 1 ]. Apoptosis, or programmed cell death, is a method of cell loss during ischemia [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Neuroprotective and Anti-Inflammatory Effects of Rhus coriaria Extract in a Mouse Model of Ischemic Optic Neuropathy

et al. 2018

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“…According to the literature, Sumac fruit possess a multitude of biological activities including beneficial effects in vivo in streptozotocin-induced diabetes [8], lipid-lowering effects in hypercholesterolemic rats [9], cardioprotective effects in hyperlipidemic patients [10,11], prevention of necrotizing enterocolitis [12], neuroprotective effects in a mouse model of ischemic optic neuropathy [13,14] and an in vitro model of retinal degeneration [15]. Moreover, Chakraborty A. and colleagues showed in vivo scavenging effects of sumac and inhibition of DNA bases oxidation, also following γ-irradiation [16].…”

Section: Introductionmentioning

confidence: 99%

Rhus coriaria L. Fruit Extract Prevents UV-A-Induced Genotoxicity and Oxidative Injury in Human Microvascular Endothelial Cells

et al. 2020

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Rhus coriaria L. (sumac) is a small plant widely diffused in the Mediterranean region. Its fruit are often consumed as a spice but are also present in traditional medicine of several countries. Recently, interest in this plant has increased and many scientific works reported its beneficial effects including antioxidant and anti-inflammatory properties. Plant extracts can be successfully used against ultraviolet rays, which are able to reach and damage the human skin; however, sumac extracts were never applied to this usage. Thus, in this study, we used a macerated ethanol extract of Rhus coriaria L. dried fruit (mERC) to demonstrate its preventive role against the damage induced by ultraviolet-A rays (UV-A) on microvascular endothelial cells (HMEC-1). In vitro effects of the extract pre-treatment and UV-A exposure were evaluated in detail. The antioxidant capacity was assessed by reactive oxygen species (ROS) formation and cellular antioxidant activity measurement. Genoprotective effects of mERC were investigated as well. Our findings indicate that the extract acts as a cell cycle inhibitor or apoptosis inducer, according to the level of damage. The present work provides new insights into the usage of Rhus coriaria extracts against skin injuries.

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Population structure of sumac (Rhus coriaria L.) from Türkiye based on transcriptome-developed SSR marker

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Khanyile

Gürcan

2022

Genet Resour Crop Evol

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Assessment of neuroprotective properties of Rhus coriaria L. ethanol extract in an in vitro model of retinal degeneration

Cited by 11 publications

References 34 publications

Neuroprotective and Anti-Inflammatory Effects of Rhus coriaria Extract in a Mouse Model of Ischemic Optic Neuropathy

Neuroprotective and Anti-Inflammatory Effects of Rhus coriaria Extract in a Mouse Model of Ischemic Optic Neuropathy

Rhus coriaria L. Fruit Extract Prevents UV-A-Induced Genotoxicity and Oxidative Injury in Human Microvascular Endothelial Cells

Population structure of sumac (Rhus coriaria L.) from Türkiye based on transcriptome-developed SSR marker

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