Assessment of nest building and social interaction behavior in mice exposed to acute social defeat stress using a three‐dimensional depth camera

Otabi, Hikari; Okayama, Takayuki; Toyoda, Atsushi

doi:10.1111/asj.13447

Cited by 8 publications

(2 citation statements)

References 63 publications

(82 reference statements)

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“…Although the decrease in the nest building quality has been well described after acute stress protocols ( Thodberg et al, 2002 ; Nollet et al, 2013a ), chronic and subchronic stress tests may require a more complex interpretation. For instance, Otabi et al (2016 , 2020) have demonstrated that although mice can build nests under chronic stress, they spend more time on the building as well an increased latency to start building compared to control mice. Furthermore, those authors observed that the time elapsed between the stress session and the nest evaluation also may influence the quality of the nest.…”

Section: Discussionmentioning

confidence: 99%

Emotional- and cognitive-like responses induced by social defeat stress in male mice are modulated by the BNST, amygdala, and hippocampus

da Costa,

Ramírez,

Ramírez

et al. 2023

Front. Integr. Neurosci.

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IntroductionChronic exposure to social defeat stress (SDS) has been used to investigate the neurobiology of depressive- and anxiety-like responses and mnemonic processes. We hypothesized that these affective, emotional, and cognitive consequences induced by SDS are regulated via glutamatergic neurons located in the bed nucleus of the stria terminalis (BNST), amygdaloid complex, and hippocampus in mice.MethodsHere, we investigated the influence of chronic SDS on (i) the avoidance behavior assessed in the social interaction test, (ii) the anxiety-like behavior (e.g., elevated plus-maze, and open field tests) (iii) depressive-like behaviors (e.g., coat state, sucrose splash, nesting building, and novel object exploration tests), (iv) the short-term memory (object recognition test), (v) ΔFosB, CaMKII as well as ΔFosB + CaMKII labeling in neurons located in the BNST, amygdaloid complex, dorsal (dHPC) and the ventral (vHPC) hippocampus.ResultsThe main results showed that the exposure of mice to SDS (a) increased defensive and anxiety-like behaviors and led to memory impairment without eliciting clear depressive-like or anhedonic effects; (b) increased ΔFosB + CaMKII labeling in BNST and amygdala, suggesting that both areas are strongly involved in the modulation of this type of stress; and produced opposite effects on neuronal activation in the vHPC and dHPC, i.e., increasing and decreasing, respectively, ΔFosB labeling. The effects of SDS on the hippocampus suggest that the vHPC is likely related to the increase of defensive- and anxiety-related behaviors, whereas the dHPC seems to modulate the memory impairment.DiscussionPresent findings add to a growing body of evidence indicating the involvement of glutamatergic neurotransmission in the circuits that modulate emotional and cognitive consequences induced by social defeat stress.

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Section: Discussionmentioning

confidence: 99%

Emotional- and cognitive-like responses induced by social defeat stress in male mice are modulated by the BNST, amygdala, and hippocampus

da Costa,

Ramírez,

Ramírez

et al. 2023

Front. Integr. Neurosci.

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“…As shown in Table 1, a specific pain scale was used in order to minimize animal pain and distress. Different parameters such as general appearance, food/water intake, behavior, nest building, were assessed as indicators of health and welfare in mice (36)(37)(38)(39). Body weight was measured weekly for mice of G1 and G2 throughout the whole experimental period and daily during the DSS treatment period for mice of G3 and G4.…”

Section: Animal Experimental Designmentioning

confidence: 99%

Lentilactobacillus kefiri SGL 13 and Andrographis paniculata alleviate dextran sulfate sodium induced colitis in mice

Manna¹,

Rizzi²,

Bafile³

et al. 2023

Front. Nutr.

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IntroductionInflammatory bowel diseases (IBD) are chronic inflammatory conditions that typically involve diarrhea, abdominal pain, fatigue, and weight loss, with a dramatic impact on patients’ quality of life. Standard medications are often associated with adverse side effects. Thus, alternative treatments such as probiotics are of great interest. The purpose of the present study was to evaluate the effects of oral administration of Lentilactobacillus kefiri (basonym: Lactobacillus kefiri) SGL 13 and Andrographis paniculata, namely, Paniculin 13™, on dextran sodium sulfate (DSS)- treated C57BL/6J mice.MethodsColitis was induced by administering 1.5% DSS in drinking water for 9 days. Forty male mice were divided into four groups, receiving PBS (control), 1.5% DSS, Paniculin 13™ and 1.5% DSS + Paniculin 13™.ResultsThe results showed that body weight loss and Disease Activity Index (DAI) score were improved by Paniculin 13™. Moreover, Paniculin 13™ ameliorated DSS-induced dysbiosis, by modulating the gut microbiota composition. The gene expression of MPO, TNFα and iNOS in colon tissue was reduced and these data matched with the histological results, supporting the efficacy of Paniculin 13™ in reducing the inflammatory response. No adverse effects were associated to Paniculin 13™ administration.DiscussionIn conclusion, Paniculin 13™ could be an effective add-on approach to conventional therapies for IBD.

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The mouse Social Frailty Index (mSFI): a novel behavioral assessment for impaired social functioning in aging mice

Collinge,

Razzoli,

Mansk

et al. 2024

GeroScience

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Various approaches exist to quantify the aging process and estimate biological age on an individual level. Frailty indices based on an age-related accumulation of physical deficits have been developed for human use and translated into mouse models. However, declines observed in aging are not limited to physical functioning but also involve social capabilities. The concept of “social frailty” has been recently introduced into human literature, but no index of social frailty exists for laboratory mice yet. To fill this gap, we developed a mouse Social Frailty Index (mSFI) consisting of seven distinct assays designed to quantify social functioning which is relatively simple to execute and is minimally invasive. Application of the mSFI in group-housed male C57BL/6 mice demonstrated a progressively elevated levels of social frailty through the lifespan. Conversely, group-housed females C57BL/6 mice manifested social frailty only at a very old age. Female mice also showed significantly lower mSFI score from 10 months of age onward when compared to males. We also applied the mSFI in male C57BL/6 mice under chronic subordination stress and in chronic isolation, both of which induced larger increases in social frailty compared to age-matched group-housed males. Lastly, we show that the mSFI is enhanced in mouse models that show accelerated biological aging such as progeroid Ercc1−/Δ and Xpg−/− mice of both sexes compared to age matched littermate wild types. In summary, the mSFI represents a novel index to quantify trajectories of biological aging in mice and may help elucidate links between impaired social behavior and the aging process.

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Assessment of nest building and social interaction behavior in mice exposed to acute social defeat stress using a three‐dimensional depth camera

Cited by 8 publications

References 63 publications

Emotional- and cognitive-like responses induced by social defeat stress in male mice are modulated by the BNST, amygdala, and hippocampus

Emotional- and cognitive-like responses induced by social defeat stress in male mice are modulated by the BNST, amygdala, and hippocampus

Lentilactobacillus kefiri SGL 13 and Andrographis paniculata alleviate dextran sulfate sodium induced colitis in mice

The mouse Social Frailty Index (mSFI): a novel behavioral assessment for impaired social functioning in aging mice

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