Assessment of Myocardial Function and Injury by Echocardiography and Cardiac Biomarkers in African Children With Severe Plasmodium falciparum Malaria*

Kotlyar, Simon; Nteziyaremye, Julius; Akech, Samuel; Uyoga, Sophie; Muhindo, Rita; Moore, Christopher L.; Maitland, Kathryn

doi:10.1097/pcc.0000000000001411

Cited by 11 publications

(19 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Minimal difference in EF was demonstrated in those with varying degrees of severity of illness or anemia. EF 58% (53–62) at admission and EF 54% (51–58) at 24 hours, p = 0.525 [ 34 ].…”

Section: Resultsmentioning

confidence: 99%

“…Cardiac index (CI), stroke index (SI) or velocity time integral (VTI), all surrogates for stroke volume, were all markedly increased during the disease process and decreased after recovery [ 28 34 ].…”

Section: Resultsmentioning

confidence: 99%

“… Normative values for SI for healthy children are 35–65 mls/m 2 . VTI–18.4 (15.8–21.4) on day 0 and 19.2 (17.4–21.3) [ 34 ]. Normative values for VTI for healthy children are 18–22 cm.…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Cardiovascular Findings in Severe Malaria: A Review

Wooldridge

Nandi

Chimalizeni

et al. 2020

View full text Add to dashboard Cite

Background: Severe malaria remains a leading cause of death worldwide. A greater understanding of its impact on multiple organ systems is essential in reducing the burden of disease. In this review we will summarize previously reported cardiovascular parameters of both adults and children with severe malaria. Method: For this systematic review we searched MEDLINE and PUBMED for all papers published on cardiac function in severe malaria from January 1, 1990 until September 1, 2019. Severe malaria was defined as per World Health Organization. Publications were included if there was data from echocardiography, Pulse Contour Cardiac Output (PiCCO), or Pulmonary Arterial catheters (PAC) reported. Studies were excluded if related to medication induced cardiac dysfunction, malaria in pregnancy, or included subjects with known pre-existing heart disease. Results: Twenty-four studies met inclusion criteria, the majority of which were studies of adult patients or a mixed cohort. Six solely involved pediatric patients. Significant heterogeneity existed in the cardiac parameters measured and results reported. One pediatric and one adult study suggested a reduced preload state during severe malaria. Cardiac systolic function was reported primarily within, or above, normative numeric ranges established in uninfected pediatric patients without anemia. Extensive variability existed in adult studies with reports of an elevated cardiac index in two studies, normal cardiac function in two studies, and descriptions of decreased function in two studies. Two reports suggest afterload in pediatric severe malaria is reduced. Reports of changes in the systemic vascular resistance of adults with severe malaria are inconsistent, with two trials demonstrating an increase and two suggesting a decrease. Studies demonstrated a mild rise in pulmonary pressure in both pediatric and adult patients that normalized by discharge. Conclusion: Based on limited data, the cardiovascular effects of severe malaria appear to be heterogeneous and vary depending on age. Further detailed studies are required to explore and understand the overall hemodynamic effects of this high burden disease.

show abstract

“…Minimal difference in EF was demonstrated in those with varying degrees of severity of illness or anemia. EF 58% (53–62) at admission and EF 54% (51–58) at 24 hours, p = 0.525 [ 34 ].…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Cardiovascular Findings in Severe Malaria: A Review

Wooldridge

Nandi

Chimalizeni

et al. 2020

View full text Add to dashboard Cite

show abstract

“…7,18,19 Bronchopneumonia has been reported in previous In a study aimed at assessing the cardiac systolic function of children with severe malaria, 48% had elevated cardiac troponin I compared to healthy controls, which may be suggestive of myocardial injury. 25 Myocardial dysfunction in children with severe malaria has been postulated to be caused by acidosis, which depresses the myocardium and has a negatively inotropic effect on the heart. 26,27 Malnutrition was associated with a higher likelihood that recovery time from heart failure would be greater than 24 hrs.…”

Section: Discussionmentioning

confidence: 99%

Factors Predicting Heart Failure in Children Admitted to a Pediatric Emergency Ward in a Developing Country

Onubogu

2020

International Journal of Cardiovascular Sciences

View full text Add to dashboard Cite

“…Although there is no study investigating the rise in cTn levels in different hemoglobin levels in large patient populations, severe anemia was shown to be related with increased troponin levels in children with malaria (132, 133). Severe anemia has also been found to relate with mortality in patients with MI and HF (134, 135).…”

Section: Severe Anemiamentioning

confidence: 99%