Assessment of muscle oxygenation with balanced SSFP: A quantitative signal analysis

Klarhöfer, Markus; Madörin, Philipp; Bilecen, Deniz; Scheffler, Klaus

doi:10.1002/jmri.21334

Cited by 10 publications

(9 citation statements)

References 24 publications

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“…In our experiments T 2 significantly increased (between 3% and 6%) during ischemia reperfusion for all observed muscles. These findings are consistent with results obtained with standard MSE (multispin‐echoes) (11) and SE‐EPI (spin‐echo echo planar imaging) sequences (12, 29).…”

Section: Discussionsupporting

confidence: 90%

“…Therefore, since muscle physiological adaptations during stress or activation can simultaneously impact several NMR physical variables, monoparametric NMR imaging quantification may not be able to account for the complexity of muscle physiology. Some attempts have been made to perform a multiparametric NMR monitoring of skeletal muscle (8–12). Interleaved acquisition of standard spin‐warp sequences with variable repetition time, inversion time, or echo times have been proposed for these multiparametric measurements.…”

mentioning

confidence: 99%

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Fast monitoring of T₁, T₂, and relative proton density (M₀) changes in skeletal muscles using an IR‐TrueFISP sequence

Sousa

Vignaud

Fleury

et al. 2011

Magnetic Resonance Imaging

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Purpose: To investigate the feasibility of fast and simultaneous assessment of T 1 , T 2 , and M 0 (relative proton density) changes in skeletal muscle studies using an inversion recovery true fast imaging with steady-state precession (TrueFISP) sequence.Materials and Methods: NMR signal dynamics in calf muscles were analyzed under four different conditions: intravenous injection of a low-molecular weight Gd contrast agent (CA), postarterial occlusion reactive hyperemia, local cooling, and an exercise bout. Experiments were conducted on a clinical 3T whole-body scanner.Results: At rest, average muscle T 1 and T 2 values obtained from the IR-TrueFISP experiments were 1.34 6 0.13 seconds and 45 6 5 msec, respectively (median 6 standard deviation). 1) Noticeable T 1 decreases (DT 1 max %À30%) were measured in the calf muscles after CA injection, while no significant changes were observed for T 2 and M 0 . 2) T 2 increased rapidly during reactive hyperemia and reached a peak value (þ6%) at about 1 minute postischemia. During ischemia, a significant decrease was observed only in the soleus muscle. No significant paradigm-related changes in M 0 and T 1 were noted in all muscle groups, except in the m. soleus (DT 1 %þ1% during reactive hyperemia). 3) Opposite variations in muscle T 1 (DT 1 max %À30%) and M 0 (DM 0 max %þ25%) associated with local cooling were detected. 4) Concomitant changes in T 1 (DT 1 max %þ15%), T 2 (DT 2 max %þ35%), and M 0 (DM 0 max %þ16%) were observed in the activated muscles following the exercise bout.Conclusion: IR-TrueFISP was sufficiently fast and sensitive to detect small and transient T 1 , T 2 , and M 0 changes in the calf muscles under different experimental conditions. The sequence offers a time-resolution adequate to track rapid physiological adaptations in skeletal muscle.

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Section: Discussionsupporting

confidence: 90%

mentioning

confidence: 99%

Fast monitoring of T₁, T₂, and relative proton density (M₀) changes in skeletal muscles using an IR‐TrueFISP sequence

Sousa

Vignaud

Fleury

et al. 2011

Magnetic Resonance Imaging

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“…According to the American College of Radiology (ACR) [17]: a BMD ≤ 80 mg/cm 3 indicates osteoporosis; a BMD ≤ 120 mg/cm 3 and > 80 mg/cm3 indicates osteopenia; and a BMD above 120 mg/cm 3 is considered normal.…”

Section: Signal Processing and Data Analysismentioning

confidence: 99%

BOLD effect on calf muscle groups in elderly females with different bone mineral density

Heather

Griffith

et al. 2014

2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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This study examined the BOLD effect on calf muscles in elderly subjects with different bone mineral density. The purpose was to investigate the oxygenation characteristics in different calf muscle groups for the elderly females and compare the muscle oxygenation among groups with different bone mineral density. Temporary vascular occlusion was induced with air-cuff compression of the thigh and BOLD-MRI data curve was fitted to derive quantitative parameters. Three muscle groups, gastrocnemius muscle (lateral head), soleus muscle, and tibialis anterior muscle, were investigated individually. Quantitative CT measurement was conducted on each subject, based on which subjects were classified into normal, osteopenia, and osteoporosis groups. The BOLD signal in soleus muscle showed the lowest minimum ischemic value during ischemia and the steepest slope during hyperemia. As soleus muscle is mainly composed by slow-twitch oxidative muscle fibers, current results may be due to a higher vascular bed density and better endothelial function in such muscle. By t-test, the half-life of the BOLD signal decay during ischemia in both gastrocnemius and soleus muscles was significantly prolonged in osteoporosis group, indicating a degenerated muscular oxygen metabolic capacity in osteoporotic patients.

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“…[1][2][3][4][5][6][7][8] Esta sequência apresenta como principal vantagem a utilização de intervalos de tempo entre os pulsos (T p ) menores que os tempos de relaxação longitudinal (T 1 ) e transversal (T 2 ). Este decréscimo de T p possibilita realizar a promediação de milhares de espectros por unidades de T 1 , proporcionando um ganho significativo na razão s/r, quando comparada com as demais sequências utilizadas na RMN.…”

Section: Introductionunclassified

Supressão das anomalias de fase e batimentos laterais em espectros de RMN 13c obtidos com a sequência de precessão livre no estado estacionário

Santos¹,

Souza²,

Colnago³

2010

Quím. Nova

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Assessment of muscle oxygenation with balanced SSFP: A quantitative signal analysis

Cited by 10 publications

References 24 publications

Fast monitoring of T₁, T₂, and relative proton density (M₀) changes in skeletal muscles using an IR‐TrueFISP sequence

Fast monitoring of T₁, T₂, and relative proton density (M₀) changes in skeletal muscles using an IR‐TrueFISP sequence

BOLD effect on calf muscle groups in elderly females with different bone mineral density

Supressão das anomalias de fase e batimentos laterais em espectros de RMN 13c obtidos com a sequência de precessão livre no estado estacionário

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Assessment of muscle oxygenation with balanced SSFP: A quantitative signal analysis

Cited by 10 publications

References 24 publications

Fast monitoring of T1, T2, and relative proton density (M0) changes in skeletal muscles using an IR‐TrueFISP sequence

Fast monitoring of T1, T2, and relative proton density (M0) changes in skeletal muscles using an IR‐TrueFISP sequence

BOLD effect on calf muscle groups in elderly females with different bone mineral density

Supressão das anomalias de fase e batimentos laterais em espectros de RMN 13c obtidos com a sequência de precessão livre no estado estacionário

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Fast monitoring of T₁, T₂, and relative proton density (M₀) changes in skeletal muscles using an IR‐TrueFISP sequence

Fast monitoring of T₁, T₂, and relative proton density (M₀) changes in skeletal muscles using an IR‐TrueFISP sequence