Assessment of muscle mass using chest computed tomography-based quantitative and qualitative measurements in patients with systemic sclerosis: A retrospective study with cross-sectional and longitudinal analyses

Rocha, Daniela Silva da; Tessari, Julia Andressa; Mainardi, Natália Bocaccio; Hax, Vanessa; Gasparin, Andrese Aline; Oliveira, Ceres Andreia Vieira de; Garcia, Tiago Severo; Xavier, Ricardo Machado; Chakr, Rafael Mendonça da Silva

doi:10.1016/j.semarthrit.2023.152168

Seminars in Arthritis and Rheumatism

2023

DOI: 10.1016/j.semarthrit.2023.152168

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Assessment of muscle mass using chest computed tomography-based quantitative and qualitative measurements in patients with systemic sclerosis: A retrospective study with cross-sectional and longitudinal analyses

Daniela Silva da Rocha

Julia Andressa Tessari

Natália Bocaccio Mainardi

et al.

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Skeletal Muscle Involvement in Systemic Sclerosis

Srpčič,

Urzi,

Markez

et al. 2023

Systemic Sclerosis - Recent Advances and New Perspectives [Working Title]

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Systemic sclerosis (SSc) is a systemic autoimmune connective tissue disease with great clinical and pathogenetic heterogeneity. Although skin is the most visible organ affected, skeletal muscles are affected in up to 96% of SSc patients and this is associated with a worse clinical outcome including increased mortality. Muscle involvement varies from patients experiencing myalgias, fibrosing myopathy to overlaps of SSc and myositis, a condition referred to as scleromyositis. In SSc muscle biopsies, muscular fibrosis, inflammation, microangiopathy and atrophy are observed, which is consistent with most prominent SSc pathophysiologic processes. The damage and fibrosis of the muscle tissue and the reduced ability of the body to build and repair muscle lead to a loss of muscle mass and strength. Studies show that patients with SSc have a higher prevalence of myopenia than the general population, but the exact cause is not yet fully understood. Partially, this phenomenon could be attributed to the disrupted activity of fibro-adipogenic progenitors, driven by alterations in the skeletal muscle microenvironment of SSc patients. These changes are also reflected in shifts in myokine secretion.

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Skeletal Muscle Involvement in Systemic Sclerosis

Srpčič,

Urzi,

Markez

et al. 2023

Systemic Sclerosis - Recent Advances and New Perspectives [Working Title]

View full text Add to dashboard Cite

show abstract

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Assessment of muscle mass using chest computed tomography-based quantitative and qualitative measurements in patients with systemic sclerosis: A retrospective study with cross-sectional and longitudinal analyses

Cited by 1 publication

References 38 publications

Skeletal Muscle Involvement in Systemic Sclerosis

Skeletal Muscle Involvement in Systemic Sclerosis

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