“…Many studies confirmed that iPSCs-derived neurons (i.e., motor neurons, cortical neurons, dopaminergic neurons, and sensory neurons) express all the necessary receptors and substrates for BoNT intoxication, and are sensitive for detection of several BoNTs serotypes with different potencies, making iPSC-derivatives cells of choice for BoNT research [ 96 , 157 , 160 , 161 , 162 , 163 ]. Motor neurons derived from hiPSCs have proved to be highly sensitive to BoNT intoxication [ 157 , 160 , 161 ]. Neurons derived from hiPSCs exhibited appropriate morphology, electrical behaviors, transsynaptic signaling and network activity.…”