Assessment of multi-chemical pollution in aquatic ecosystems using toxic units: Compound prioritization, mixture characterization and relationships with biological descriptors

Ginebreda, Antoni; Kuzmanović, Maja; Guasch, Helena; Alda, Miren López de; López-Doval, Júlio C.; Muñoz, Isabel; Ricart, Marta; Romaní, Anna M.; Sabater, Sergi; Barceló, Damià

doi:10.1016/j.scitotenv.2013.08.086

Cited by 103 publications

(55 citation statements)

References 35 publications

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“…These varied discharges are gotten from both point and non-point sources which are either discharged directly or indirectly into water or ultimately through run-offs and seepages [25,29]. Organisms in aquatic environments are usually exposed to a complex mixture of chemicals including parent compound and their transformation products causing multiple damages at the organisms, population and ecosystem level, in organ function, reproductive stages and biological diversity [10,33]. River Galma receives variable levels of pollution from different anthropogenic activities along its banks [3].…”

Section: Introductionmentioning

confidence: 99%

Histopathological alterations in kidney and liver of Clarias gariepinus (burchell, 1822) studied in river galma, Nigeria

Samuel¹,

Adakole²,

Suleiman³

et al. 2017

Appl Sci Rep

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The river ecosystem serves as ultimate sink for myriads of xenobiotic all over the world with deleterious effects on the living biota within it. Histopathological alterations in kidney and liver of the catfish Clarias gariepinus (Burchell, 1822) were studied in River Galma, Zaria Nigeria. Twenty-five samples of Clarias gariepinus were exposed to the river ecosystem at the peak of rainfall in August, 2015 for 14 days at five stations along River Galma, using the cage system. Fish samples and controls from each station were subsequently harvested and transported to the laboratory for histopathological examination of liver and kidney. Results from photomicrographs of tissues from different stations revealed varying histopathological alterations which ranged from vacuolation, constrictions, necrosis and aggregations of cells to congestion of the blood vessels. These results indicated that River Galma is witnessing pollution. This calls for ameliorative measures by relevant authorities so as to protect aquatic life as well as the public from the toxic effects of aquatic environmental pollution.

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Section: Introductionmentioning

confidence: 99%

Histopathological alterations in kidney and liver of Clarias gariepinus (burchell, 1822) studied in river galma, Nigeria

Samuel¹,

Adakole²,

Suleiman³

et al. 2017

Appl Sci Rep

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“…They occur in practically all streams and rivers substrata, and biofilm functions, such as photosynthesis, respiration and nutrients uptake, are at the base of key ecological functions of fluvial ecosystems (Guasch and Sabater, 1995;Battin et al, 2003), here including contaminants removal (Lawrence et al, 2001;Writer et al, 2011;Corcoll et al, 2012). Pharmaceuticals perform a combined effect of mixed substances on non-target aquatic biota (Fent et al, 2006;Rosi-Marshall and Royer, 2012;Ginebreda et al, 2014). Further, differences in sensitivity between autotrophs and heterotrophs to chemicals (Tlili et al, 2011), and the occurrence of indirect effects between biofilm components (Ricart et al, 2009) make prediction of pharmaceutical effects difficult.…”

Section: Introductionmentioning

confidence: 99%

Effects of flow intermittency and pharmaceutical exposure on the structure and metabolism of stream biofilms

Corcoll

Casellas

Huerta

et al. 2015

Science of The Total Environment

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“…If we only take into account the adduct # 1, which is common to the three sites, it appears that it increases at the both sites downstream Paris, whereas it decreases at Marnay. The specific adduct found in organs of mussels from Marnay could be due to other pollutants including pesticides or pharmaceuticals (Ginebreda et al, 2014). Globally, more individual adducts and higher amount of adduct # 1, which correspond to B(a)P adducts, are formed in digestive glands rather than in gills as mostly demonstrated in literature (Châtel et al, 2012;Skarphéinsdóttir et al, 2003).…”

Section: Dna Adduct Formationmentioning

confidence: 86%

Genotoxicity and activation of cellular defenses in transplanted zebra mussels Dreissena polymorpha along the Seine river

Châtel¹,

Faucet-Marquis

Gourlay-Francé³

et al. 2015

Ecotoxicology and Environmental Safety

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The aim of the present study was to confirm the relevance of studying DNA adduct formation in a field study. In that context, freshwater mussels Dreissena polymorpha, collected in a reference station, were transplanted in different sites with a pollution gradient. After one and two months, mussels were collected and DNA adduct formation was analyzed using the (32)P post labelling technique on both gills and digestive glands. In addition, the expression of genes involved in the detoxification system (catalase (CAT), superoxide dismutase (SOD), glutathione S-transferase (GST), HSP70, aryl hydrocarbon receptor (AHR), P glycoprotein (PgP), metallothionein (MT)) was assessed by RT-PCR. DNA adducts were observed at amount comparable to data from literature. Increase of DNA adducts after two months of transplantation could be correlated with strong modulation of gene expression implicated in detoxification processes. Indeed, PgP and HSP70 gene expressions were similarly induced in gills and digestive glands while SOD and CAT expressions were down regulated in both tissues. AHR, GST and MT genes were differently regulated depending upon the tissue studied and the level of contamination in the different sites. We demonstrated that mussels transplanted in the different stations with pollution gradient were able to biotransform PAHs, assessed by DNA adduct formation and the high decrease of detoxification genes. Specific DNA adducts pattern obtained after one and two month mussel transplantations demonstrated the relevance of DNA adduct as biomarker of environmental pollution.

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Assessment of multi-chemical pollution in aquatic ecosystems using toxic units: Compound prioritization, mixture characterization and relationships with biological descriptors

Cited by 103 publications

References 35 publications

Histopathological alterations in kidney and liver of Clarias gariepinus (burchell, 1822) studied in river galma, Nigeria

Histopathological alterations in kidney and liver of Clarias gariepinus (burchell, 1822) studied in river galma, Nigeria

Effects of flow intermittency and pharmaceutical exposure on the structure and metabolism of stream biofilms

Genotoxicity and activation of cellular defenses in transplanted zebra mussels Dreissena polymorpha along the Seine river

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