Assessment of movement time in patients with essential tremor

Özekmekçi, Sibel; Kızıltan, Güneş; Vural, Melih; Ertan, Sibel; Apaydın, Hülya; Erginöz, Ethem

doi:10.1007/s00415-005-0793-0

Cited by 19 publications

(16 citation statements)

References 14 publications

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“…Comparisons with healthy subjects, as well as with the less affected side in ET patients themselves, demonstrated that ET was associated with decreased arm and leg frequencies, especially on the dominantly affected side of the body. These results are compatible with our previous study in which we showed some degree of prolonged movement time around the shoulder joint during repetitive movements in ET patients compared to age-matched controls [11]. In parallel, reviewing the video recordings, we observed that decreased associated arm movements were especially prominent in the proximal parts of the arms while walking, although not quantitatively measured.…”

Section: Discussionsupporting

confidence: 92%

“…Slowness of movement during a fast wrist flexion/extension has been demonstrated in patients with ET with performance levels comparable to those of patients with mild PD [10]. In our previous study, we also showed that ET patients performed rapid alternating arm movements slower than those of controls, especially on proximal arm segments, though this difference was not significant [11]. Later, Duval et al [12] confirmed the presence of bradykinesia during rapidly alternating movement in ET patients and concluded that slow movements should be considered part of ET symptomatology.…”

Section: Introductionmentioning

confidence: 80%

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Quantitative Analysis of Reduced Arm Swing Frequency in Essential Tremor

et al. 2010

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Background: Essential tremor (ET) has recently been accepted as a heterogeneous disorder which may be associated with synuclein pathology or a variety of other genetic disorders. Methods: We observed decreased arm swing frequency in 18 of 136 definite ET patients, and recorded the associated arm movements in 18 ET patients and 33 sex- and age-matched healthy controls. Results: The mean frequency of the right arm (p = 0.047), left arm (p = 0.025) and leg (p = 0.030), and the mean arm/leg frequency on the right side (p = 0.048) were significantly lower in ET patients. The mean frequencies for both arms and legs were significantly lower for the more affected side of the body (p = 0.034 and p = 0.036, respectively). Conclusion: We conclude that ET may be associated with decreased arm and leg swing frequencies, especially on the more affected side of the body.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 80%

Quantitative Analysis of Reduced Arm Swing Frequency in Essential Tremor

et al. 2010

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“…Although several studies describe an abnormal olivo‐cerebellar network in ET,2–4 recent evidence suggests a neurodegenerative pathophysiology and even an overlap with Parkinson disease (PD). Indeed, ET is clinically progressive5 and several signs, such as bradykinesia,6–8 rest tremor,9 and hyposmia10–12 may be observed in ET. Moreover, a population‐based study revealed that patients with ET were four times more likely than unrelated healthy controls to develop incident PD 13.…”

Section: Introductionmentioning

confidence: 99%

Imaging essential tremor

et al. 2010

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To investigate over time changes in striatal dopamine transporter (DAT), we performed two sequential N-omega-fluoropropyl-2beta-carbomethoxy-3beta-(4-iodophenyl) tropane single photon computed tomography (SPECT) scans in 20 subjects with essential tremor (ET), in 13 with Parkinson disease (PD) and in 23 healthy controls (HC, one scan only). We also performed an [(99m)Tc]ethyl cysteinate dimer bicisate SPECT exam for regional brain network analysis in 9 ET, in a second group of 18 PD (9 with tremor, tPD and 9 akinetic-rigid dominant, arPD) and in 8 HC. PD subjects had a reduced DAT binding in comparison to ET and HC with an annual decline rate of 7.3% in the contralateral putamen. There were no mean uptake differences between ET and HC at baseline and no uptake loss over time in ET. A discriminant analysis grouped 30% (first scan) and 5% (second scan) of ET as PD and a partition analysis showed overlap between ET and PD for caudate nucleus uptake. Spatial covariance analysis revealed that the expression of the PD-related regional pattern separated both tPD and arPD from ET and HC. In conclusion, PD and ET do not share a common pattern of dopaminergic loss over time. However, mild impairment of dopamine transporter in the caudate nucleus may contribute to tremor onset in ET.

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“…They found that the initiation of the movements of participants with ET was time-locked to the tremor circle, suggesting that not the execution itself, but the movement initiation is affected when performing rhythmic behavior. Support for this suggestion that the execution of rhythmic behavior is unaffected by ET has been provided by Ozekmekci et al (2005), who found that individuals with ET and controls did not perform differently a sequential-tapping task. Whereas the previous research suggested that initiation is largely unaffected in ET, other studies did show that both movement initiation and execution were affected (Montgomery, Baker, Lyons, & Koller, 2000;Jimenez-Jimenez et al, 2010).…”

mentioning

confidence: 85%

Characterization of graphomotor functions in individuals with Parkinson’s disease and essential tremor

Gemmert

Chang

2016

Behav Res

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In this study, we explored the relationship between the clinical features and motor impairments related to the graphomotor function of individuals with Parkinson's disease (PD) and essential tremor (ET). We recruited 46 participants: 12 with PD, 13 with ET, and 21 controls. All participants were asked to perform six graphomotor tasks on a digitizer tablet: drawing straight lines, cursive-connected loops, discrete circles, and continuous circles, and making goal-aimed movements with a stylus in two different directions with three different accuracy constraints. The results showed that although participants with PD were able to draw straight lines slightly faster than controls, they produced cursive-connected loops much slower than controls. In addition, in contrast to controls and individuals with ET, PDs also drew the cursive loops progressively smaller. In the aiming task, we found that equivalent movements with high accuracy constraints were drawn slower by individuals with ET or PD than by controls. However, when performing the equivalent movements with moderate or low accuracy constraints, PDs performed similarly to controls. In contrast to the equivalent movements, PD and ET participants both performed nonequivalent movements slower than controls, no matter the demands arising from the accuracy constraints. The present study shows that simple graphic tasks can differentiate impairments in fine motor function resulting from ET and PD.

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Assessment of movement time in patients with essential tremor

Cited by 19 publications

References 14 publications

Quantitative Analysis of Reduced Arm Swing Frequency in Essential Tremor

Quantitative Analysis of Reduced Arm Swing Frequency in Essential Tremor

Imaging essential tremor

Characterization of graphomotor functions in individuals with Parkinson’s disease and essential tremor

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