Assessment of Mitral Annulus Velocity by Doppler Tissue Imaging in the Evaluation of Left Ventricular Diastolic Function

Sohn, Dae‐Won; Chai, In-Ho; Lee, Dongjun; Kim, Hee Chan; Kim, Hyo–Soo; Oh, Byung‐Hee; Lee, Hae Young; Park, Young-Bae; Choi, Yun-Shik; Seo, Jung-Don; Lee, Young-Woo

doi:10.1016/s0735-1097(97)88335-0

Cited by 1,401 publications

(1,015 citation statements)

References 14 publications

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“…Flow velocity mapping revealed an increase in the E/A peak flow ratio at the three-month follow-up, which was mainly determined by an improvement in the E peak filling rate, whereas the A peak filling rate remained unchanged. Assessment of diastolic mitral annular velocities with TDI (a relatively load-insensitive estimation of myocardial relaxation) (13,14), revealed similar results. In particular, the EЈ significantly increased, whereas the AЈ remained unchanged.…”

Section: Discussionmentioning

confidence: 73%

Effect of intramyocardial bone marrow cell injection on diastolic function in patients with chronic myocardial ischemia

Beeres

Lamb

Roes

et al. 2008

Magnetic Resonance Imaging

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Purpose:To evaluate the effect of intramyocardial bone marrow cell injection on diastolic function in patients with chronic myocardial ischemia. Materials and Methods:In 24 patients (19 male; 65 Ϯ 9 years) with refractory angina (Canadian Cardiovascular Society [CCS] class III-IV) 84.6 Ϯ 28.7 ϫ 10 6 bone marrowderived mononuclear cells were injected intramyocardially (using the NOGA system) in regions with ischemia on Tc99m tetrofosmin single photon emission computed tomography (SPECT). Diastolic function was evaluated at baseline and at three months using magnetic resonance imaging (MRI) and tissue Doppler imaging (TDI).Results: MRI revealed an increased early (E) peak filling rate (374 Ϯ 121 mL/second vs. 412 Ϯ 102 mL/second; P ϭ 0.04), whereas the atrial (A) peak filling rate remained unchanged (340 Ϯ 81 mL/second vs. 334 Ϯ 93 mL/second; P ϭ not significant [NS]). The E/A peak flow ratio increased from 1.09 Ϯ 0.33 to 1.23 Ϯ 0.47 at three months (P ϭ 0.02). TDI demonstrated a significant improvement in early diastolic velocity (EЈ) from 4.4 Ϯ 1.7 cm/second to 4.8 Ϯ 1.6 cm/second at three months (P ϭ 0.03), whereas the late diastolic velocity (AЈ) remained unchanged (6.0 Ϯ 1.6 cm/ second vs. 6.0 Ϯ 1.7 cm/second; P ϭ NS). Consequently, the EЈ/AЈ ratio increased from 0.74 Ϯ 0.19 to 0.84 Ϯ 0.28 at three months (P ϭ 0.02). Conclusion:Intramyocardial bone marrow cell injection in patients with chronic myocardial ischemia improved MRI and TDI-derived parameters of diastolic function.

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Section: Discussionmentioning

confidence: 73%

Effect of intramyocardial bone marrow cell injection on diastolic function in patients with chronic myocardial ischemia

Beeres

Lamb

Roes

et al. 2008

Magnetic Resonance Imaging

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“…Pulsed‐wave Doppler examination of mitral inflow and Doppler tissue imaging of the mitral annulus were performed in each patient 10, 11. To provide a continuous variable that would reflect diastolic elastance (Ed), E/e′ was examined, where E is the early diastolic mitral inflow velocity and e′ is the early diastolic mitral annular velocity 12, 13. We measured e′ averaged from septal and lateral part of the mitral annulus.…”

Section: Methodsmentioning

confidence: 99%

Age‐ and sex‐related differences in diastolic function and cardiac dimensions in a hypertensive population

Hoshida¹,

Shinoda²,

Ikeoka³

et al. 2016

ESC Heart Failure

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AimsThe prevalence of left ventricular diastolic dysfunction increases with age, particularly in hypertensive women. We aimed to determine the age‐ and sex‐related differences in diastolic function, and its relation to alterations of cardiac dimensions in a hypertensive population.Methods and resultsWe enrolled 479 hypertensive patients with a left ventricular ejection fraction (LVEF) ≥50% (men/women, 267/212) and their echocardiographic parameters regarding LV performance and vascular function were measured. Left atrial volume index (LAVI) and operant diastolic elastance (EdI: E/e′/stroke volume index), but not LV mass index (LVMI), correlated weakly with age in both sexes. The arterial elastance index (EaI) and EdI did not differ significantly between sexes in any of the three age groups (A, <65 years; B, ≥65 years but <75 years; C, age ≥75 years). The EdI indexed to EaI, EdI/EaI = E/e′/(0.9 × systolic blood pressure), was significantly more impaired in women than in men only in group C. There were significant differences in LAVI, LVMI, and EdI/EaI between groups B and C only in women.ConclusionsImpairment of diastolic function relative to arterial elasticity, EdI/EaI, occurred in elderly hypertensive women and was coincident with the alteration of cardiac dimensions. The coincidence with the changes in diastolic function and the alterations of cardiac dimensions occurred in a different time point between the sexes.

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“…Tissue Doppler imaging evaluated the septal and lateral ventricular walls as previously described. 12 Peak spectral longitudinal contraction (Sm), initial (Em) and final (Am) diastolic velocities for three consecutive beats were analyzed. Systolic volume was generated from Doppler interrogation of transaortic flow at the aortic annular level and aortic cross-sectional area.…”

Section: Methodsmentioning

confidence: 99%

Altered left ventricular diastolic function in subjects with spinal cord injury

et al. 2010

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Study design: This is cross-sectional study. Objectives: The aim of this study is to investigate the cardiac structure and function of subjects with spinal cord injury (SCI) and the impact of metabolic, hemodynamic and inflammatory factors on these parameters. Setting: São Paulo, Brazil. Methods: Sixty-five nondiabetic, nonhypertensive, sedentary, nonsmoker men (34 with SCI and 31 healthy subjects) were evaluated by medical history, anthropometry, laboratory tests, analysis of hemodynamic and inflammatory parameters and echocardiography. Results: Subjects with SCI had lower systolic blood pressure and higher levels of C-reactive protein and tumor necrosis factor receptors than the healthy ones. Echocardiography data showed that the SCI group presented similar left ventricular (LV) structural and systolic parameters, but lower initial diastolic velocity (Em) (9.2 ± 0.5 vs 12.3 ± 0.5 cm s À1 ; Po0.001) and higher peak early inflow velocity (E)/Em ratio (7.7±0.5 vs 6.1±0.3; P ¼ 0.009) compared with the able-bodied group, even after adjustment for systolic blood pressure and C-reactive protein levels. Furthermore, injured subjects with E/Em 48 had lower peak spectral longitudinal contraction (Sm) (9.0±0.7 vs 11.6±0.4 cm s À1 ; Po0.001) and cardiac output (4.2 ± 0.2 vs 5.0 ± 0.2 l min À1 ; P ¼ 0.029), as well as higher relative wall thickness (0.38±0.01 vs 0.35±0.01; P ¼ 0.005), than individuals with SCI with E/Emo8, but similar age, body mass index, blood pressure, injury level, metabolic parameters and inflammatory marker levels. Conclusion: Subjects with SCI presented impaired LV diastolic function in comparison with ablebodied ones. Moreover, worse LV diastolic function was associated with a pattern of LV concentric remodeling and subclinical decreases in systolic function among injured subjects. Overall, these findings might contribute to explain the increased cardiovascular risk reported for individuals with SCI.

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Assessment of Mitral Annulus Velocity by Doppler Tissue Imaging in the Evaluation of Left Ventricular Diastolic Function

Abstract: Mitral annulus velocity determined by DTI is a relatively preload-independent variable in evaluating diastolic function.

Cited by 1,401 publications

References 14 publications

Effect of intramyocardial bone marrow cell injection on diastolic function in patients with chronic myocardial ischemia

Effect of intramyocardial bone marrow cell injection on diastolic function in patients with chronic myocardial ischemia

Age‐ and sex‐related differences in diastolic function and cardiac dimensions in a hypertensive population

Altered left ventricular diastolic function in subjects with spinal cord injury

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