Assessment of menopause-induced myocardial changes by integrated backscatter during inotropic stimulation and atropine injection

Ho, Yi-Lun; Lin, Lung-Chun; Yen, Men‐Luh; Wu, Cho‐Kai; Chow, Song‐Nan; Huang, Pei‐Hsin

doi:10.1016/s0301-5629(02)00529-x

Cited by 2 publications

(2 citation statements)

References 30 publications

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“…Furthermore, studies have shown that menopause, characterized by markedly decreased levels of estrogen, leads to significant increases in cardiovascular mortality and morbidity . Although there are many studies focusing on the relationship between menopause and adverse cardiovascular events, the published work on cardiac structure and function is comprised of only a few studies . In these few studies, menopause has been shown to have an impact on cardiovascular structure and functions, however, these studies appear to have many limitations such as different age groups and lack of advanced echocardiography techniques.…”

Section: Introductionmentioning

confidence: 99%

Menopausal cardiomyopathy: Does it really exist? A case–control deformation imaging study

Kurt

Nacar

Güler

et al. 2014

J of Obstet and Gynaecol

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Section: Introductionmentioning

confidence: 99%

Menopausal cardiomyopathy: Does it really exist? A case–control deformation imaging study

Kurt

Nacar

Güler

et al. 2014

J of Obstet and Gynaecol

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“…Changes of cardiac fibroblast and myocyte activities may develop after menopause as a consequence of reduction of estrogen concentration. Ho et al [28] evaluated the myocardial CVIBS and MIBS in pre-and post-menopausal women. They showed that postmenopausal women had higher MIBS values than premenopausal women.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the effects of new and conventional hormone replacement therapies on left ventricular diastolic function in healthy postmenopausal women: a Doppler and ultrasonic backscatter study

Duygu¹,

Akman

Özerkan

et al. 2009

Int J Cardiovasc Imaging

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We aimed to compare the effects of new treatment modalities to conventional hormone replacement therapy (HRT) on left ventricular (LV) diastolic function, by means of conventional and tissue Doppler echocardiography and the myocardial integrated backscatter (IBS) in postmenopausal women. One hundred and fifty healthy postmenopausal women were included in this study. Subjects were assigned to one of the five groups receiving 1 year of treatment (estrogen, estrogen plus progesterone, raloxifene, tibolone or placebo). E and A wave velocity, E/A ratio, isovolumic relaxation time (IVRT), deceleration time (DT), peak early (Em) diastolic mitral annular velocity, E/Em ratio, the cyclic variation of integrated backscatter (CVIBS) and the mean value of the IBS signal (MIBS) were determined before and 12 months after therapy. E (76 +/- 10 vs. 98 +/- 8 cm/s, P = 0.0001 and 78 +/- 10 vs. 90 +/- 12 cm/s, P = 0.02, respectively), Em (14.3 +/- 2.4 vs. 16.4 +/- 2.5 cm/s, P = 0.001 and 15.1 +/- 3.4 vs. 16.2 +/- 3.5 cm/s, P = 0.01, respectively), and E/A ratio (1.15 +/- 0.3 vs. 1.42 +/- 0.4, P = 0.0001 and 1.0 +/- 0.2 vs. 1.22 +/- 0.2, P = 0.01, respectively) were increased significantly compared to pretreatment in both estrogen and raloxifene groups while DT, A, E/Em, and IVRT were significantly decreased. A significant increase in CVIBS and decrease in MIBS were detected 12 months after estrogen and raloxifene administration while no significant changes were observed in other groups. Changes in the MIBS and CVIBS were found to be independently associated with the observed changes in the diastolic function indexes during therapy. Both estrogen and raloxifene regimens may improve LV diastolic functions in healthy postmenopausal women. This improvement may be a result of direct cardiac effects on LV myocardium.

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Assessment of menopause-induced myocardial changes by integrated backscatter during inotropic stimulation and atropine injection

Cited by 2 publications

References 30 publications

Menopausal cardiomyopathy: Does it really exist? A case–control deformation imaging study

Menopausal cardiomyopathy: Does it really exist? A case–control deformation imaging study

Comparison of the effects of new and conventional hormone replacement therapies on left ventricular diastolic function in healthy postmenopausal women: a Doppler and ultrasonic backscatter study

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