Assessment of Meniere's disease from a radiological aspect – saccular otoconia as a cause of Meniere's disease?

Yamane, Hideo; Sunami, Kishiko; Iguchi, Hiroyoshi; Sakamoto, Hitoshi; Imoto, Tatsuya; Rask‐Andersen, Helge

doi:10.3109/00016489.2012.680980

Cited by 33 publications

(31 citation statements)

References 18 publications

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“…This difference was most observable for HV thresholds, which reinforces the evidence of predominantly saccular dysfunction in these patients [5, 32]. Second, thresholds were lowest in VM, but not significantly lower than thresholds measured in HC.…”

Section: Discussionsupporting

confidence: 81%

Comparison of linear motion perception thresholds in vestibular migraine and Menière’s disease

Bremova-Ertl

Caushaj

Ertl

et al. 2016

Eur Arch Otorhinolaryngol

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Linear motion perceptual thresholds (PTs) were compared between patients with Menière’s disease (MD) and vestibular migraine (VM). Twenty patients with VM, 27 patients with MD and 34 healthy controls (HC) were examined. PTs for linear motion along the inter-aural (IA), naso-occipital axes (NO), and head-vertical (HV) axis were measured using a multi-axis motion platform. Ocular and cervical vestibular evoked myogenic potentials (o/c VEMP) were performed and the dizziness handicap inventory (DHI) administered. In order to discriminate between VM and MD, we also evaluated the diagnostic accuracy of applied methods. PTs depended significantly on the group tested (VM, MD and HC), as revealed by ANCOVA with group as the factor and age as the covariate. This was true for all motion axes (IA, HV and NO). Thresholds were highest for MD patients, significantly higher than for all other groups for all motion axes, except for the IA axis when compared with HC group suggesting decreased otolith sensitivity in MD patients. VM patients had thresholds that were not different from those of HC, but were significantly lower than those of the MD group for all motion axes. The cVEMP p13 latencies differed significantly across groups being lowest in VM. There was a statistically significant association between HV and NO thresholds and cVEMP PP amplitudes. Diagnostic accuracy was highest for the IA axis, followed by cVEMP PP amplitudes, NO and HV axes. To conclude, patients with MD had significantly higher linear motion perception thresholds compared to patients with VM and controls. Except for reduced cVEMP latency, there were no differences in c/oVEMP between MD, VM and controls.

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Section: Discussionsupporting

confidence: 81%

Comparison of linear motion perception thresholds in vestibular migraine and Menière’s disease

Bremova-Ertl

Caushaj

Ertl

et al. 2016

Eur Arch Otorhinolaryngol

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“…To determine the patency of these ducts, in a previous study we examined whether 3D CT images showed or did not show continuity of the luminal spaces of these ducts (Figure 1) [9]. When luminal spaces on a 3D CT image were totally absent, the ducts were defined as occluded, and any other states were defined as patent.…”

Section: Introductionmentioning

confidence: 99%

“…In the present study we used the same subjects as in the previous study [9], to allow comparison with the present study. We classified the 3D CT images of the ducts based on their occlusion patterns to obtain more precise information on MD, and investigated the relationships between pattern and MD stage.…”

Section: Introductionmentioning

confidence: 99%

Blockage pattern of longitudinal flow in Meniere's disease

Takano

Iguchi

Sakamoto

et al. 2013

Acta Oto-Laryngologica

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Conclusion: In the present study, classification of the patterns of 3D CT images of the ductus reuniens (reuniting duct) (RD), saccular duct (SD), and endolymphatic sinus (ES) gave more precise information for assessing the pathological condition of Meniere's disease (MD) than our previous study. Objective: This study attempted to provide more detailed information on MD by classifying the patterns of 3D CT images of the RD, SD, and ES in patients with MD. Methods: We examined the ears of 62 patients with definitely diagnosed unilateral MD based on the criteria of the Committee on Hearing and Equilibrium of the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) using 3D CT. The 3D CT images of bony grooves of RD, SD, and ES (BRD, BSD, and BES) were classified into patterns according to aspects of their patency. Results: BRD could be classified into six types by assessing their patency defined using the criteria in this study. In the ears on the affected side of patients with MD, the BRD, BSD, and BES lost continuity in 3D CT images along their bony routes and were significantly different from normal healthy ears (p < 0.01). There were no significant differences among each stage of MD in the distributions of BRD and BES except for BSD.

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“…Otoconia: Studies using three-dimensional (3D) computerized tomography (CT) imaging in patients show that hydrops in MD patients might be caused by obstruction of the duct reunions by loose otoconia in the saccule [13].…”

Section: Etiology Of the Hydropsmentioning

confidence: 99%

Pathophysiology of Meniere's Disease

Mirza¹,

Gokhale²

2017

Up to Date on Meniere's Disease

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Meniere's disease, with its characteristic symptom triad of vertigo, balance and hearing disorders has yet to have its pathophysiology outlined conclusively. Any theory must elucidate all aspects of the natural progression, including vestibular and auditory symptoms. While the central dogma revolves around endolymphatic hydrops, this theory is not without laws, such as its inability to explain all the physiological changes seen in patients, or the often absence of symptoms. While several degenerative changes are observed in temporal bone histopathology, they do not necessarily explain the sequence of events in the development and progress of the disease. This chapter explores the pathophysiology of the disease, focusing on the hydrops theory, while presenting evidence for and against it. Various changes in the inner ear physiology such as pressure changes, ionic disequilibrium, endocochlear potentials; in human and animal models are described. Alternative explanations for symptoms are discussed. This chapter touches briely upon etiology associated with Meniere's (and hydrops), and aims to assist a deeper understanding of the relationship of the process to clinical and experimental indings. A clear understanding of the process guides not only the clinical management to improve quality of life but also the direction of future research endeavors.

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Assessment of Meniere's disease from a radiological aspect – saccular otoconia as a cause of Meniere's disease?

Cited by 33 publications

References 18 publications

Comparison of linear motion perception thresholds in vestibular migraine and Menière’s disease

Comparison of linear motion perception thresholds in vestibular migraine and Menière’s disease

Blockage pattern of longitudinal flow in Meniere's disease

Pathophysiology of Meniere's Disease

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