Assessment of median lethal dose and anti-mutagenic effects of Glycyrrhiza glabra root extract against chemically induced micronucleus formation in Swiss albino mice

Sharma, Vivek; Agrawal, R. C.; Shrivastava, Vinoy K.

doi:10.5455/2319-2003.ijbcp20140407

Cited by 16 publications

(7 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…AEGGL and Dm might be act on receptor and ion channels at molecular level to protect from chronic ethanolic effects. The lethal dose 50 (LD50) of AEGGL was observed at the dose of 833.3 mg/kg body weight [14]. This might be an advantage to treat patients in dosedependent manner.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of Aqueous Extract of Glycyrrhiza Glabra Linn. And Diosmetin on Modulation of Spatial Memory Through Acetylcholinesterase and Brain‑derived Neurotrophic Factor in Ethanol-Induced Cognitive Impairment Model Rats

Sasikumar

Manikandan

et al. 2018

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objective: The objective of this research was to evaluate the cognitive impairment due to excessive consumption of alcohol and memory enhancement action of Glycyrrhiza glabra Linn. (AEGGL) and diosmetin (Dm).Methods: In this study, 36 adult male Wistar rats were divided into the six groups (n=6) and eight-arm radial maze, narrow beam test, and open field behavior parameters were assessed on day 1, 10, and 21. After the 21 days of experiment, animals were sacrificed, and blood samples were collected for serum acetylcholinesterase (AChE) and brain-derived neurotrophic factor (BDNF) estimation. We have also analyzed the morphology of CA3 region of the hippocampus.Results: The results of this study suggested that AEGGL and Dm treatment could be the potential drugs for ethanol-induced cognitive impairment.Conclusion: Ethanol-induced cognitive impairment was recovered by AEGGL and Dm treatment, we suggested that this might be due to anticholinesterase activity and increased synthesis of BDNF levels in the brain. Further, researches are warranted to understand the exact mechanism of action of drugs.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Enhancement action of GGL (AEGGL) is one of the herbal extracts, commonly used Indian system of medicine for enhancing learning and memory [13]. AEGGL has lethal dose as higher that can be used for chronic consumption [14]. Dm is known antioxidant molecule which is responsible for the protective effect against neurotoxicity [15].…”

Section: Introductionmentioning

confidence: 99%

Effects of Aqueous Extract of Glycyrrhiza Glabra Linn. And Diosmetin on Modulation of Spatial Memory Through Acetylcholinesterase and Brain‑derived Neurotrophic Factor in Ethanol-Induced Cognitive Impairment Model Rats

Sasikumar

Manikandan

et al. 2018

Asian J Pharm Clin Res

View full text Add to dashboard Cite

show abstract

“…Ohtsuki et al () reported the in vivo inhibition of Ehrlich ascites tumour cell growth by the aqueous and methanolic extracts of G. glabra , with the corresponding reduction in cell number, body weight, and ascites volume. The hydromethanolic root extract of G. glabra also exhibited antimutagenic potential by suppressing micronuclei formation and chromosomal aberration in bone marrow cells of albino mice (V. Sharma, Agrawal, & Shrivastava, ). Glycyrrhizin and glycyrrhetinic acids are effective compounds in gastric cancer treatment, whereas glycyrrhizin suppresses thromboxane A2 in lung cancer cell with low toxicity (Deng, Wang, Zeng, Chen, & Huang, ).…”

Section: Pharmacological Propertiesmentioning

confidence: 99%

Liquorice (Glycyrrhiza glabra): A phytochemical and pharmacological review

Pastorino

Cornara

Soares

et al. 2018

Phytotherapy Research

456

332

View full text Add to dashboard Cite

In the last years, consumers are paying much more attention to natural medicines and principles, mainly due to the general sense that natural compounds are safe. On the other hand, there is a growing demand by industry for plants used in traditional medicine that could be incorporated in foods, nutraceuticals, cosmetics, or even pharmaceuticals. Glycyrrhiza glabra Linn. belongs to the Fabaceae family and has been recognized since ancient times for its ethnopharmacological values. This plant contains different phytocompounds, such as glycyrrhizin, 18β-glycyrrhetinic acid, glabrin A and B, and isoflavones, that have demonstrated various pharmacological activities. Pharmacological experiments have demonstrated that different extracts and pure compounds from this species exhibit a broad range of biological properties, including antibacterial, anti-inflammatory, antiviral, antioxidant, and antidiabetic activities. A few toxicological studies have reported some concerns. This review addresses all those issues and focuses on the pharmacological activities reported for G. glabra. Therefore, an updated, critical, and extensive overview on the current knowledge of G. glabra composition and biological activities is provided here in order to explore its therapeutic potential and future challenges to be utilized for the formulation of new products that will contribute to human well-being.

show abstract

“…Methanolic licorice extract and its isolated compound, licocoumarone, were documented to stimulate the phosphorylation of BCl 2 and halt the G2/M cycle in cancer cell lines and to induce human monoblastic leukemia U937 cells apoptosis. Furthermore, hydromethanolic root extract demonstrated antimutagenic activity by suppressing the formation of micronucleus and chromosomal abnormalities in the bone marrow cells of albino mice [64,65]. Recently, Yoon et al [66] revealed that the novel retrochalcone component, licochalcone E that was isolated from G. inflate root extract, showed potent cytotoxic activity in comparison with the famous antineoplastic drugs (isoliquiritigenin and licochalcone A).…”

Section: In Vitro Pharmacological/biological Properties Of G Glabra mentioning

confidence: 99%

“…Moreover, glycyrrhizin has been reported to be used in the treatment of acetaminophen-induced hepatotoxicity and it acts by inhibiting CCl 4 -induced membrane lipid peroxidation [95]. Several reports documented the in vivo anticancer efficacy of aqueous G. glabra extract and its related components [64]. Shi et al [96] revealed the uterine relaxant and analgesic efficacies of isoliquiritigenin, which was inhibited by L-NAME and indomethacin (COX-1/COX-2 inhibitor).…”

Section: In Vivo Pharmacological/biological Properties Of G Glabra Ementioning

confidence: 99%

Traditional Uses, Bioactive Chemical Constituents, and Pharmacological and Toxicological Activities of Glycyrrhiza glabra L. (Fabaceae)

et al. 2020

View full text Add to dashboard Cite

Traditional herbal remedies have been attracting attention as prospective alternative resources of therapy for diverse diseases across many nations. In recent decades, medicinal plants have been gaining wider acceptance due to the perception that these plants, as natural products, have fewer side effects and improved efficacy compared to their synthetic counterparts. Glycyrrhiza glabra L. (Licorice) is a small perennial herb that has been traditionally used to treat many diseases, such as respiratory disorders, hyperdipsia, epilepsy, fever, sexual debility, paralysis, stomach ulcers, rheumatism, skin diseases, hemorrhagic diseases, and jaundice. Moreover, chemical analysis of the G. glabra extracts revealed the presence of several organic acids, liquirtin, rhamnoliquirilin, liquiritigenin, prenyllicoflavone A, glucoliquiritin apioside, 1-metho-xyphaseolin, shinpterocarpin, shinflavanone, licopyranocoumarin, glisoflavone, licoarylcoumarin, glycyrrhizin, isoangustone A, semilicoisoflavone B, licoriphenone, and 1-methoxyficifolinol, kanzonol R and several volatile components. Pharmacological activities of G. glabra have been evaluated against various microorganisms and parasites, including pathogenic bacteria, viruses, and Plasmodium falciparum, and completely eradicated P. yoelii parasites. Additionally, it shows antioxidant, antifungal, anticarcinogenic, anti-inflammatory, and cytotoxic activities. The current review examined the phytochemical composition, pharmacological activities, pharmacokinetics, and toxic activities of G. glabra extracts as well as its phytoconstituents.

show abstract

Assessment of median lethal dose and anti-mutagenic effects of Glycyrrhiza glabra root extract against chemically induced micronucleus formation in Swiss albino mice

Cited by 16 publications

References 13 publications

Effects of Aqueous Extract of Glycyrrhiza Glabra Linn. And Diosmetin on Modulation of Spatial Memory Through Acetylcholinesterase and Brain‑derived Neurotrophic Factor in Ethanol-Induced Cognitive Impairment Model Rats

Effects of Aqueous Extract of Glycyrrhiza Glabra Linn. And Diosmetin on Modulation of Spatial Memory Through Acetylcholinesterase and Brain‑derived Neurotrophic Factor in Ethanol-Induced Cognitive Impairment Model Rats

Liquorice (Glycyrrhiza glabra): A phytochemical and pharmacological review

Traditional Uses, Bioactive Chemical Constituents, and Pharmacological and Toxicological Activities of Glycyrrhiza glabra L. (Fabaceae)

Contact Info

Product

Resources

About