Assessment of Mean Platelet Volume in Patients with Systemic Lupus Erythematosus

Hartmann, L; Alegretti, Ana Paula; Machado, Alice Beatriz Mombach Pinheiro; Martins, Eduardo Ferreira; Chakr, Rafael Mendonça da Silva; Gasparin, Andrese Aline; Monticielo, Odirlei André

doi:10.2174/1874312901812010129

Cited by 17 publications

(21 citation statements)

References 35 publications

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“…The rapid, sensitive, and specific evaluation of disease activity in patients with SLE are important for short-term and longterm treatment planning. Previous studies have shown that inflammatory factors, including tumor-necrosis factor-a (TNF-a), complement C3, complement C4, the mean platelet volume, the neutrophil to lymphocyte ratio, IL-6, and IF-34, were associated with the severity of SLE [3,[16][17][18][19]. The findings from these previous studies support that inflammatory cytokines play an essential role in the pathogenesis and etiology of SLE.…”

Section: Discussionmentioning

confidence: 73%

Serum Amyloid A: A Potential Biomarker Assessing Disease Activity in Systemic Lupus Erythematosus

et al. 2020

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Background: This study aimed to investigate the association between levels of serum amyloid A (SAA) and the activity of systemic lupus erythematosus (SLE). Material/Methods: The study included 135 patients with SLE, including 52 patients with active SLE and 83 patients with inactive SLE and 149 healthy controls. The degree of activity of SLE was assessed using the SLE Disease Activity Index 2000 (SLEDAI-2K). Serum SAA levels were measured using a Cobas 8000 c702 modular analyzer. Results: The levels of SAA were significantly increased in patients with active SLE compared with patients with inactive SLE (median IQR, 16.65 mg/L; range, 9.35-39.68 mg/L, and median IQR, 2.30 mg/L, range, 1.30-4.80 mg/L) (p<0.001). Levels of SAA were significantly correlated with the SLEDAI-2K scores, the erythrocyte sedimentation rate (ESR), and hypersensitive C-reactive protein (Hs-CRP) in patients with SLE (r=0.726, p<0.001; r=0.631, p<0.001; r=0.774, p<0.001, respectively). Multivariate logistic regression analysis showed that the SAA values were independently associated with active SLE when controlled for white blood cell (WBC) count, red blood cell distribution width (RDW), ESR, and Hs-CRP (OR=1.772; p=0.01; 95% CI, 1.101-2.851). Receiver operating characteristic (ROC) curve analysis for SAA was used to identify patients with active SLE with an area under the curve of 0.971, a sensitivity of 90.4%, and a specificity of 94.0%. Conclusions: SAA levels were significantly correlated with disease activity in patients with SLE.

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Section: Discussionmentioning

confidence: 73%

Serum Amyloid A: A Potential Biomarker Assessing Disease Activity in Systemic Lupus Erythematosus

et al. 2020

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“…Hartmann et al. 12 found that no correlation between MPV and CRP, ESR, C3 and C4.Also, Delgado-García et al. found no correlation between MPV and ESR (p = 0.26).…”

Section: Discussionmentioning

confidence: 96%

“…Also, Hartmann et al. 12 and Delgado-García et al. 13 found that adult patients with active SLE had decreased MPV when compared to inactive disease group.…”

Section: Discussionmentioning

confidence: 98%

Mean platelet volume in children with systemic lupus erythematosus

Talat

Allah

Khalifa

et al. 2020

Lupus

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Background Platelets are heterogeneous in size, density, metabolic, functional, and biochemical properties. Mean platelet volume (MPV) is a measure of the average size of platelet in a blood sample. Aim We aimed to evaluate the mean platelet volume as a marker for disease activity in children with systemic lupus erythematosus. Materials and Methods This was a prospective case-control study, which included 50 patients with SLE and 50 age and sex, matched healthy controls. All subjects were subjected to history taking, physical examination and laboratory parameters in active and remission phases of the diseases. Results The MPV value in the SLE group was significantly higher than control group (9.6 ± 1.3 fL, 9.1 ± 0.57 fL, respectively, p = 0.04). There was a significant increase of weight, blood pressure, urea, creatinine, proteinuria, CRP, ESR, cholestrol, MPV values, SLEDAI-2K scores and significant decrease of HB, albumin, C3, mean platelet volume (MPC) in the active stage than in the remission stage. There was a significant negative correlation between MPV and MPC in active stage of the disease but the correlation was insignificant in remission stage. Conclusion MPV increased in active phase of patients with SLE and can be an easy, rapid, inexpensive and simple method to assess disease activity in children with SLE.

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“…Data on the usefulness of the MPV in other inflammatory diseases are divergent. In the acute phase of rheumatic diseases, a decrease in MPV [33,34] or its increase associated with higher activity of juvenile idiopathic arthritis, psoriatic arthritis, SLE may occur [5,35,36]. Some studies indicate the usefulness of MPV in monitoring anti-inflammatory therapy in rheumatoid arthritis [37].…”

Section: Discussionmentioning

confidence: 99%

Analysis of neutrophil to lymphocyte ratio, platelet to lymphocyte ratio and mean platelet volume to platelet count ratio in children with acute stage of immunoglobulin A vasculitis and assessment of their suitability for predicting the course of the disease

et al. 2019

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Immunoglobulin A vasculitis (IgAV) is the most common systemic vasculitis in developmental age. The disease is most often characterized by a self-limiting course and good prognosis, but sometimes serious complications, like gastrointestinal bleeding or glomerulonephritis, may develop. The neutrophil to lymphocyte (NLR) and the platelet to lymphocyte (PLR) ratios are indicators related to clinical outcome in various inflammatory diseases. The mean platelet volume to platelet count ratio (MPR) has not been evaluated in patients with IgAV. The aim of this study was to analyze the values of the NLR, PLR and MPR in patients with an acute stage of IgAV compared to healthy children and to assess their suitability for predicting the severity of the disease. All children with IgAV hospitalized in our institution between 2012 and 2017 were reviewed retrospectively. The selected laboratory data were recorded before starting the treatment; these results allowed for NLR, PLR, and MPR calculation. The study involved 71 IgAV children. 57.7% of patients revealed signs of systemic involvement (including GT bleeding and/or glomerulonephritis) and 42.3% were nonsystemic (presenting skin and joint symptoms). 83% of patients were classified as mild and 17% as severe course of the disease. The NLR and the PLR were significantly higher in all IgAV children and in the systemic involvement group in comparison with non-systemic. The MPR was significantly lower in all IgAV group with the exception of children without systemic involvement. The NLR is a more valuable indicator than the PLR to identify patients at higher risk of systemic involvement in the course of IgAV. Clinical usefulness of the MPR requires further research.

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Assessment of Mean Platelet Volume in Patients with Systemic Lupus Erythematosus

Cited by 17 publications

References 35 publications

Serum Amyloid A: A Potential Biomarker Assessing Disease Activity in Systemic Lupus Erythematosus

Serum Amyloid A: A Potential Biomarker Assessing Disease Activity in Systemic Lupus Erythematosus

Mean platelet volume in children with systemic lupus erythematosus

Analysis of neutrophil to lymphocyte ratio, platelet to lymphocyte ratio and mean platelet volume to platelet count ratio in children with acute stage of immunoglobulin A vasculitis and assessment of their suitability for predicting the course of the disease

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