Assessment of management of cardiovascular risk factors in patients with thoracic aortic disease

Bastien, Marjorie; Dagenais, François; Dumont, Éric; Vadeboncoeur, Nathalie; Dion, B.; Royer, Maryse; Gaudet-Savard, Thierry; Poirier, Paul

doi:10.1097/mbp.0b013e32835b9e74

Cited by 5 publications

(3 citation statements)

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“…Aortic diseases can be inherited, inflammatory, traumatic or degenerative (Erbel et al, 2001). Thoracic aortic diseases occur at a rate of 16.3 and 9.4 cases per 100000 per year for men and women respectively in Europe (Bastien et al, 2012).…”

Section: Aortic Dissectionmentioning

confidence: 99%

Aortic Dissection: Simulation Tools for Disease Management and Understanding

Alimohammadi

2018

Springer Theses

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Section: Aortic Dissectionmentioning

confidence: 99%

Aortic Dissection: Simulation Tools for Disease Management and Understanding

Alimohammadi

2018

Springer Theses

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“…Thoracic aortic diseases occur between 16 to 10 per 100000 per year for both men and women in Europe [2], among which, aortic dissection (AD), and its associated vascular diseases and further complications, are relatively poorly understood. One of these complication is calcification of the aortic wall, which carries with it significant risks and increased mortality rates [3,4].…”

Section: Introductionmentioning

confidence: 99%

Predicting Atherosclerotic Plaque Location in an Iliac Bifurcation Using a Hybrid CFD/Biomechanical Approach

Alimohamadi

Pichardo‐Almarza

Tomaso

et al. 2015

Bioinformatics and Biomedical Engineering

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Abstract. Experimental evidence indicates that haemodynamic stimuli influence some properties of the arterial endothelium, such as cell geometry and permeability, leading to possible accumulation of blood-borne macromolecules and initiation of atherosclerosis. Patient-specific computational models are able to capture complex haemodynamic characteristics to explore and analyse the development of these diseases in silico. Patient-specific models are particularly beneficial in the case of aortic dissection (AD), a condition in which the aortic wall is split in two, creating a true and a false lumen. In this condition, the proportion of blood through the main vessel and the main aortic branches is substantially modified and malperfusion (lack of blood supply) of the downstream vessels is often observed. Furthermore, AD alters the haemodynamics downstream of the lesion, potentially leading to the formation of atherosclerotic plaques at the iliac bifurcation. In order to correctly approximate the haemodynamic changes and analyse the role they play in the development of atherosclerosis formations in AD patients, a combined multiscale methodology is required. In this study, both, blood flow through an iliac bifurcation of a patient suffering from type-B aortic dissection and endothelium behavior are analysed, in order to investigate atherosclerosis formation.

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“…This shows that MFS patients are not protected from obesity. Obesity in MFS patients increases the risk of pre‐existing cardiovascular complications, such as aneurysm formation and aortic dissection (Orio et al 2007; Bastien et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Fibrillin-1 and fibrillin-1-derived asprosin in adipose tissue function and metabolic disorders

Muthu

Reinhardt

2020

J. Cell Commun. Signal.

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The extracellular matrix microenvironment of adipose tissue is of critical importance for the differentiation, remodeling and function of adipocytes. Fibrillin-1 is one of the main components of microfibrils and a key player in this process. Furin processing of profibrillin-1 results in mature fibrillin-1 and releases the C-terminal propeptide as a circulating hunger hormone, asprosin. Mutations in the fibrillin-1 gene lead to adipose tissue dysfunction and causes Marfan syndrome, marfanoid progeroid lipodystrophy syndrome, and neonatal progeroid syndrome. Increased TGF-β signaling, altered mechanical properties and impaired adipogenesis are potential causes of adipose tissue dysfunction, mediated through deficient microfibrils. Circulating asprosin on the other hand is secreted primarily by white adipose tissue under fasting conditions and in obesity. It increases hepatic glucose production and drives insulin secretion and appetite stimulation through inter-organ cross talk. This review discusses the metabolic consequences of fibrillin-1 and fibrillin-1-derived asprosin in pathological conditions. Understanding the dynamic role of fibrillin-1 in the adipose tissue milieu and of circulating asprosin in the body can provide novel mechanistic insights into how fibrillin-1 may contribute to metabolic syndrome. This could lead to new management regimens of patients with metabolic disease.

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Assessment of management of cardiovascular risk factors in patients with thoracic aortic disease

Abstract: Cardiovascular risk factors, particularly BP, are not well controlled in patients with TAD followed in a dedicated clinic when compared with another high-risk control group in a cardiac rehabilitation program.

Cited by 5 publications

References 0 publications

Aortic Dissection: Simulation Tools for Disease Management and Understanding

Aortic Dissection: Simulation Tools for Disease Management and Understanding

Predicting Atherosclerotic Plaque Location in an Iliac Bifurcation Using a Hybrid CFD/Biomechanical Approach

Fibrillin-1 and fibrillin-1-derived asprosin in adipose tissue function and metabolic disorders

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