Assessment of Macular Choroidal Thickness by Optical Coherence Tomography and Angiographic Changes in Central Serous Chorioretinopathy

Jirarattanasopa, Pichai; Ooto, Sotaro; Tsujikawa, Akitaka; Yamashiro, Kenji; Hangai, Masanori; Hirata, Miyuki; Matsumoto, Akiko; Yoshimura, Nagahisa

doi:10.1016/j.ophtha.2012.02.021

Cited by 196 publications

(125 citation statements)

References 43 publications

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“…26,27 Abnormalities of the choroid or CT have been demonstrated in a number of disease states, including exudative age-related macular degeneration, idiopathic polypoidal choroidal vasculopathy, central serous retinopathy, Vogt-Koyanagi-Harada disease, and high myopia. [28][29][30][31][32] Previous work using OCT has established that CT is positively correlated with refraction, negatively correlated with axial length, and that CT declines with age. [16][17][18][19][33][34][35] Evidence of prematurity affecting central, and not only peripheral, vasculature was reported by Mintz-Hittner et al, 36 who showed a reduced foveal avascular zone in prematurely born children.…”

Section: Discussionmentioning

confidence: 99%

“…CT measurements were made manually and therefore may be susceptible to error, although good interobserver agreement was observed. Measurements at discrete sampling points may be influenced by focal thickening or thinning of the choroid, or irregularity of the chorioscleral border, thus it is possible that these points may not always be representative of the CT. 30 We recorded refractive error, but it would be useful to investigate the effect of axial length in this setting in future work, particularly as high myopia in regressed ROP is associated with altered anterior segment development, a more globular lens, and increased corneal power, and not solely axial length. 40,41 Furthermore, it would be beneficial for future studies to include a premature cohort without ROP to determine whether choroidal thinning is associated with ROP only or whether prematurity per se has an effect on CT.…”

Section: Discussionmentioning

confidence: 99%

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Choroidal thickness in regressed retinopathy of prematurity

Anderson

Ramasamy

Lythgoe

et al. 2014

Eye

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Purpose To compare choroidal thickness in patients with regressed retinopathy of prematurity (ROP) with healthy controls using enhanced depth imaging optical coherence tomography (EDI OCT) Methods Twenty-four children and young adults (41 eyes) with regressed ROPZstage 3 had undergone EDI OCT with Spectralis FD-OCT as part of their clinical record. Their refraction, best-corrected visual acuity, and ophthalmoscopic findings were recorded. Corresponding data was collected prospectively from 33 healthy controls (58 eyes) who had been born at term. Choroidal thickness was measured independently by two observers subfoveally and at 1500 mm nasal and temporal to the fovea using EDI OCT. Results Mean subfoveal choroidal thickness, adjusted for refraction, was 271.1 mm (95% CI, 247.8-294.5) in the ex-ROP group, which was significantly thinner than 327.4 mm (95% CI, 293.8-360.9) in controls (P ¼ 0.008). Similarly, mean adjusted temporal choroidal thickness was 257.2 mm (95% CI, 240.2-274.2) in ex-ROP's vs 320.5 mm (95% CI, 288.6-352.3) in controls (P ¼ 0.001). There was no statistically significant difference in the nasal measurement. In the ex-ROP group, there was no significant correlation between subfoveal choroidal thickness and gestational age (r s ¼ 0.16, P ¼ 0.46) or birthweight (r s ¼ 0.03, P ¼ 0.90). In eyes without copathology in addition to regressed ROP (29 eyes, 19 patients), there was no significant correlation between subfoveal choroidal thickness and visual acuity. Conclusions Our findings of thinner subfoveal and temporal macular choroidal thickness in regressed ROP support the case for choroidal involvement in the pathogenesis of this condition.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Choroidal thickness in regressed retinopathy of prematurity

Anderson

Ramasamy

Lythgoe

et al. 2014

Eye

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“…10,12,13 To our knowledge, the unique aspect of the current study is the measurement of subretinal fluid volume and its correlation with subfoveal choroidal thickness and macular volume. The analysis showed that SRF volume does not correlate with subfoveal choroidal thickness and macular volume.…”

Section: Discussionmentioning

confidence: 99%

“…These facts led to the expectation that the choroid might become thickened in CSC, and the current study confirmed this using EDI-OCT and consistent with previous studies. 10,12,13 However, it remains unclear as to whether or not thicker choroid on OCT is associated with larger SRF volume. If this is indeed the case, the assessment of choroidal thickness may prove to be a useful clinical indicator for the monitoring of SRF volume.…”

Section: Discussionmentioning

confidence: 99%

Correlation of subretinal fluid volume with choroidal thickness and macular volume in acute central serous chorioretinopathy

Goktas

2014

Eye

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Correlation of subretinal fluid volume with choroidal thickness and macular volume in acute central serous chorioretinopathy A Goktas AbstractPurpose To evaluate the correlation of subretinal fluid volume with choroidal thickness and macular volume in acute central serous chorioretinopathy (CSC). Methods Twenty patients with acute unilateral treatment-naive idiopathic CSC and 20 age-matched normal eyes were included in this prospective cross-sectional study. Subretinal fluid volume (SRFV) of study eyes was estimated using a built-in segmentation-modifying tool of Spectralis spectral-domain optic coherence tomography (SD-OCT). Subfoveal choroidal thickness (SCT) (measured with enhanced depth imaging-OCT) and macular volume (MV) were also determined. The correlation of SRFV with SCT and MV was analyzed statistically. Results There was no significant correlation of SRFV with SCT and MV in the study eyes (r ¼ 0.062, P ¼ 0.796 and r ¼ À0.061, P ¼ 0.798, respectively). The mean SCT of the study eyes, the fellow eyes and the control eyes were 461.4±101.4, 375.3±103.7, 287.6±62.5 mm, respectively (Po0.001). The mean modified MV (determined excluding SRF volume) of the study eyes, the macular volume of the fellow and the control eyes was 8.57 ± 0.59 mm 3 , 8.75 ± 0.4 mm 3 and 8.73±0.38 mm 3 , respectively (P40.05). Conclusions The current study shows that subretinal fluid volume does not correlate with subfoveal choroidal thickness. This novel finding suggests that formation of subretinal fluid is not solely associated with choroidal vasculature in acute CSC.

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“…In 2008, Spaide et al, reported the technique of enhanced depth imaging (EDI) OCT (820-nm wavelength), which is capable of obtaining images from deep layers of the retina. This has enabled the technique to be used to investigate choroidal diseases such as central serous chorioretinopathy, age-related macular degeneration, and polypoidal choroidal vasculopathy (12)(13)(14) . In this study, we aimed to compare the subfoveal choroidal thickness (SFCT) of patients with OSAHS and control subjects using EDI-OCT. Also, the study examined whether a relationship exists bet ween different clinical grades of OSAHS and choroidal thicknesses.…”

Section: Evaluation Of Choroidal Thickness In Patients With Obstructimentioning

confidence: 99%

Evaluation of choroidal thickness in patients with obstructive sleep apnea/hypopnea syndrome

Kara¹,

Özçimen²,

Bekçi³

et al. 2014

Arquivos Brasileiros De Oftalmologia

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Obstructive sleep apnea/hypopnea syndrome (OSAHS) is characterized by transient upper airway resistance caused by a recurrent reduction or cessation of airflow, due to partial or complete occlusion of the upper airway during sleep. It is associated with sleep fragmentation, arousals, bradycardia, tachycardia, and inadequate oxygen saturation despite an increased respiratory effort (1) . Major clinical consequences of the disorder include excessive daytime sleepiness, neurocognitive dysfunction, cardiovascular diseases (hypertension, ABSTRACTPurpose: To compare the subfoveal choroidal thickness (SFCT) of patients with different severities of obstructive sleep apnea/hypopnea syndrome (OSAHS) and normal controls via enhanced depth imaging optical coherence tomography (EDI-OCT). Methods: In this retrospective, case-control study, 49 eyes from 49 patients that had undergone polysomnography were included. SFCT of the horizontal and vertical line scans were manually measured for all eyes based on EDI-OCT images. Two separate analyses were performed according to different apnea/hypopnea index (AHI) groupings. Initial testing was conducted using non-OSAHS, mild OSAHS (5≤AHI<15), moderate OSAHS (15≤AHI<30), and severe OSAHS (AHI≥30) patient groupings, while secondary testing used non-OSAHS, mild OSAHS (5≤AHI<15), and moderate/severe OSAHS (AHI≥15) patient groupings. Results: The mean SFCT was 314.5 µm in the non-OSAHS patients (n=14), 324.5 µm in the mild OSAHS patients (n=15), 269.3 µm in the moderate OSAHS patients (n=11), and 264.3 µm in the severe OSAHS patients (n=9). SFCT between the four groups revealed no significant differences despite a trend towards slight thinning in the severe group (P=0.08). When the moderate and severe groups were merged and compared with the mild OASHS and non-OSAHS groups, SFCT of the moderate/severe group was found to be significantly thinner than that of the mild group (P=0.016). A negative significant correlation was found between SFCT and AHI in OSAHS patients (r=0.368, P=0.033). Conclusions:In patients with moderate/severe OSAHS, EDI-OCT revealed a thinned SFCT. Other accompanying systemic or ocular diseases may induce perfusion and oxygenation deficiency in eyes of OSAHS patients. Further studies are required in order to determine the exact relationships between ocular pathologies and clinical grades of OSAHS. Keywords

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Assessment of Macular Choroidal Thickness by Optical Coherence Tomography and Angiographic Changes in Central Serous Chorioretinopathy

Cited by 196 publications

References 43 publications

Choroidal thickness in regressed retinopathy of prematurity

Choroidal thickness in regressed retinopathy of prematurity

Correlation of subretinal fluid volume with choroidal thickness and macular volume in acute central serous chorioretinopathy

Evaluation of choroidal thickness in patients with obstructive sleep apnea/hypopnea syndrome

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