Assessment of Lung Water Distribution by Nuclear Magnetic Resonance: A New Method for Quantifying and Monitoring Experimental Lung Injury

Cutillo, A; Morris, Alan H.; Ailion, David C.; Case, Thomas A.; Durney, Carl H.; Ganesan, K.; Watanabe, Fumi; Akhtari, Massoud

doi:10.1164/ajrccm/137.6.1371

Cited by 25 publications

(11 citation statements)

References 14 publications

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“…Repeated measures of lung water by NMR vary by about 5-10% [20]. Numerous studies have reported a good correlation between NMR-determined estimates of lung water and estimates from the gold-standard gravimetric method [21,22,23,24,25,26].…”

Section: Imaging Methodsmentioning

confidence: 99%

Untitled

Lange

Schuster

1999

Crit Care

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Introduction:In this review, we compare the spectrum of currently available methods for quantifying pulmonary edema in patients.Review: Imaging and indicator dilution techniques comprise the most common strategies for measuring lung water at the bedside. The most accurate (within 10% of the gravimetric gold standard) and most reproducible (<5% betweentest variation) are also, unfortunately, the most expensive and most difficult to implement for purposes of large-scale clinical trials or for routine clinical practice. Conclusion:The standard chest radiograph remains the best screening test for the detection of pulmonary edema. Indicator-dilution techniques are probably the best available method at present for quantitation in patient groups.

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Section: Imaging Methodsmentioning

confidence: 99%

Untitled

Lange

Schuster

1999

Crit Care

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“…Also, abnormalities in lung hypoxia have been described in vivo in the isolated pigs lung [6]. Studies of lung edema with MRS have also proven useful [7]. Two methods of lung injury in the rat were chosen for study.…”

Section: Discussionmentioning

confidence: 99%

Hypoxic and Complement-Induced Lung Injury in the Isolated Perfused Rat Lung as Determined by Phosphorous-31 Nuclear Magnetic Resonance

Glovsky

Farrow

Ross

et al. 1992

Int Arch Allergy Immunol

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Magnetic resonance spectroscopy (MRS) is a non-invasive method of obtaining biochemical information. Patients or experimental animals are placed within a magnetic imaging device and specific patterns of chemical spectra, such as P³¹ patterns of adenosine triphosphate (ATP) can be recorded. We have injured the isolated rat lung by complement activation and hypoxia. Nuclear magnetic resonance patterns of phosphate metabolites revealed markedly diminished lung concentrations of ATP and phosphocreatine. In vivo measurement of lung metabolism through MRS may be a useful tool to measure metabolism of severe lung disease in man.

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“…1 B). not monoexponential (13). Whole lung and regional pHzO values are therefore reported only to document their variability among lung regions or their changes associated with pulmonary edema.…”

Section: Discussionmentioning

confidence: 99%

“…NMR lung water content was measured in a coronal (frontal) lung section midway between the anterior and posterior chest wall, which in previous studies has been found to be adequately representative of the whole lung (13). The right and left lungs were outlined using a cursor (the mediastinal structures were excluded).…”

Section: Methodsmentioning

confidence: 99%

“…During this 40-min interval the average coronal lung slice water density (see below) increased by 9 f 9% in normal rats and 18 f 14% in rats with lung edema. Lung water content and distribution were analyzed by a new method describing the distribution of lung water density (pH20, water content per unit lung volume) (13). The method displays the distribution of fractional lung volume ( Vf, expressed as the number of lung voxels having a specific water density divided by the total number of voxels) as a function of pH20.…”

Section: Methodsmentioning

confidence: 99%

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Regional effects of repetition time on NMR quantitation of water in normal and edematous lungs

Cutillo¹,

Morris²,

Ganesan³

et al. 1989

Magnetic Resonance in Med

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It is well known that pulmonary edema is, in general, spatially nonuniform. Since the NMR spin-lattice relaxation time (T1) is increased by lung edema, the spatial distribution of T1 will be nonuniform. When the repetition time (TR) is short relative to the T1 of edematous lung, lung water content will be underestimated and this underestimation will be spatially nonuniform as well. Therefore, technical artifacts which are a complex function of lung edema and its spatial distribution are expected. We compared overall and regional (topographic) lung water density measurements obtained from living rats (with normal or edematous lungs) using repetition times of 2.0 and 6.2 s (at a magnetic field of 1 T), to quantify this uneven T1 effect for normal and edematous lungs. NMR measurements at TR = 2.0 s underestimated whole lung water density (-rho H2O) TR = 6.2 s) by an average of 7.2% in normal rats and 22.5% in rats with pulmonary edema. Regional -rho H2O underestimation (%delta-rho H2O) varied from 2.2 to 8.8% (groups means) in normal lungs and from 7.3 to 30.8% in edematous lungs. As a result, the interquartile range (of the voxel distribution as a function of rho H2O) underestimated the spatial nonuniformity of lung water density by 28.0% in edematous lungs, likely because of greater loss of NMR signal from high-water-density, long-T1 lung regions. Both %delta-rho H2O and T1 were significantly correlated with -rho H2O at TR = 6.2 s.(ABSTRACT TRUNCATED AT 250 WORDS)

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Assessment of Lung Water Distribution by Nuclear Magnetic Resonance: A New Method for Quantifying and Monitoring Experimental Lung Injury

Cited by 25 publications

References 14 publications

Untitled

Untitled

Hypoxic and Complement-Induced Lung Injury in the Isolated Perfused Rat Lung as Determined by Phosphorous-31 Nuclear Magnetic Resonance

Regional effects of repetition time on NMR quantitation of water in normal and edematous lungs

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