Assessment of low-density lipoprotein oxidation, paraoxonase activity, and arterial distensibility in epileptic children who were treated with anti-epileptic drugs

Yıldız, Mustafa; Şimşek, Gönül; Uzun, Hafize; Uysal, Serap; Şahin, Sevim; Balcı, Huriye

doi:10.1017/s1047951110000697

Cited by 26 publications

(21 citation statements)

References 39 publications

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“…This is plausible when it is considered that arterial stiffness is influenced by elastic fiber degeneration, increased collagen and hypertrophy in vascular smooth muscle layers, all of which are related to oxidative stress 10) ; however, data are limited and controversial regarding the association among PON1 and AS. Yang et al reported an association between PON1 levels, carotid intima thickness and cf-PWV, whereas Yildiz et al found no association in patients with epilepsy 10,11) . Several limitations of our study should be noted.…”

Section: Discussionmentioning

confidence: 98%

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Serum Paraoxonase 1 Activity Predicts Arterial Stiffness in Renal Transplant Recipients

Güngör

Kırçelli

Demirci

et al. 2011

JAT

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Aim: Paraoxanase 1 (PON 1) has been shown to protect against atherosclerosis by modifying lipoproteins. Its activity decreases in dialysis patients but is restored after transplantation. Whether it affects arterial stiffness is unclear. In this study we aimed to investigate the effects of PON 1 on arterial stiffness in renal transplant patients. Methods: Seventy renal transplant recipients were enrolled. Arterial stiffness was measured using a Syphmocor device. PON-1 activity was assessed from the rate of enzymatic hydrolysis of paraoxon to p-nitrophenol.

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Section: Discussionmentioning

confidence: 98%

“…In one study, low PON1 levels were shown to be an independent predictor of carotid-femoral PWV (cf-PWV) in hypertensive patients 10) . In contrast, Yildiz et al reported no association between PON1 levels and AS 11) . Thus, in this cross-sectional study we aimed to investigate the association between PON1 and AS in RT patients.…”

Section: Introductionmentioning

confidence: 90%

Serum Paraoxonase 1 Activity Predicts Arterial Stiffness in Renal Transplant Recipients

Güngör

Kırçelli

Demirci

et al. 2011

JAT

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“…34,35 According to current data, there are a few studies in the literature in which connection of PON1 with PWV were evaluated. 18,39,40 Recently, we investigated the mechanism of the effect of valproic acid, carbamazepine, and valproic acid+carbamazepine by determining serum levels of oxidized low-density lipoprotein, apolipoprotein A1, homocysteine, folic acid, vitamin B12, PON1, total antioxidant capacity, malondialdehyde, nitric oxide and thyroid hormones in pediatric epileptic patients. 18 Besides the level of apolipoprotein A1, the activity of PON1 remained unaffected in pediatric patients who used antiepileptic drugs.…”

Section: Paraoxonasementioning

confidence: 99%

“…[6][7][8][9][10][11][12][13][14][18][19][20] In fact, the most important factor contributing to increased aortic PWV in humans is age because it causes increased arterial stiffness due to decreased elastin fiber, increased collagenous material and loss of arterial elasticity. [21][22][23] Increased medial calcification and endothelial dysfunction are also characteristics of arterial aging.…”

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confidence: 99%

The Carotid-Femoral (Aortic) Pulse Wave Velocity and Paraoxonase 1 Activity: Review

Yıldız¹

2012

Turkiye Klinikleri J Med Sci

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“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15] Although there are several methods currently available to assess arterial stiffness, researchers and clinicians still face problems in selecting the best methodology for their specific use. This paper summeries the advantages and disadvantages of pulse wave velocity (PWV) and augmentation index (AI) in the assessment of arterial stiffness.…”

Section: Assessment Of Arterial Stiffness With Pulse Wave Velocity Ormentioning

confidence: 99%

Assessment of Arterial Stiffness with Pulse Wave Velocity or Augmentation Index: Which Method is the Best?: Scientific Letter

Yıldız¹,

Aykan²,

Hasdemir³

2012

Turkiye Klinikleri J Med Sci

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A AB BS ST TR RA AC CT T Assesment of large arterial stiffness is increasingly used in clinal settings. Although there are several invasive and non-invasive methods such as carotid-femoral pulse wave velocity (PWV) and augmentation index (AI), researchers and clinicians still face problems in selecting the best methodology for their specific use. PWV, which is defined as the velocity of the arterial pulse for moving along the vessel wall, plays an important clinical role in defining patients under high cardiovascular risk and it is inversely correlated with arterial elasticity and relative arterial compliance. PWV along the aorta can be measured by using two ultrasound or pressure sensitive transducers fixed transcutaneously over the course of a pair of arteries separated by a known distance: the femoral and right common carotid arteries. PWV is calculated from measurements of pulse transit time and the distance, according to the following formula: PWV (m/s)= distance (m)/transit time (s). AI is defined as Dp/pp (where Dp is the difference between the late systolic peak and the mid-systolic peak and pp is the amplitude of the pulse pressure wave). Central blood pressure and pulse pressure, the AI and PWV, which are often used incorrectly as interchangeable indexes of arterial stiffness, increase with age, hypertension, diabetes mellitus and hyperlipidemia, and are associated with target organ damage such as left ventricular hypertrophy, microalbuminuria, carotid intima-media thickness and endothelial dysfunction. Althouhg the carotid-femoral (aortic) PWV is the gold standard test for assessing central arterial stiffness, the AI reflects stiffness of the systemic arterial tree. This paper summaries the advantages and disadvantages of PWV and AI in the assessment of arterial stiffness. K Ke ey y W Wo or rd ds s: : Pulse; arteries; atherosclerosis; inflammation Ö ÖZ ZE ET T Büyük arterlerin sertliğinin değerlendirilmesi klinikte giderek artan sıklıkta kullanılmak-tadır. Arteriyel sertliğin değerlendirilmesinde karotid-femoral nabız dalga hızı ve artırma göster-gesi gibi invaziv ve non-invaziv yöntemler olmakla birlikte, araştırmacılar ve klinisyenler, bunların özgül kullanımları için en uygun yöntemi seçmede halen sorun yaşamaktadırlar. Nabız dalga hızı, arteriyel nabzın damar duvarı boyunca hareketinin hızı olarak tanımlanır ve arteriyel sertliğin bir göstergesi olarak yüksek kardiyovasküler risk altındaki hastaları tanımlamada önemli rol oynar. Arteryel elastisite ve rölatif arteriyel kompliyans ile ters ilişkilidir. Nabız dalga hızı aorta boyunca belli bir aralıkla ayrılmış bir çift arter boyunca (femoral ve sağ ana karotid arterler) transkütanöz yerleştirilmiş iki ultrason veya basınca duyarlı iletme sistemleri kullanılarak nabız transit zamanı ve uzaklık ölçümlerinden şu formüle göre hesaplanır: Nabız dalga hızı (m/s)=uzaklık (m)/ transit zamanı (s). Artırma göstergesi Dp/pp olarak tanımlanır (Dp: Geç sistolik zirve ve orta sistolik zirve arasındaki fark; pp: Nabız basınç dalgasının amplitüdü). Sıklıkla yanlış...

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Assessment of low-density lipoprotein oxidation, paraoxonase activity, and arterial distensibility in epileptic children who were treated with anti-epileptic drugs

Cited by 26 publications

References 39 publications

Serum Paraoxonase 1 Activity Predicts Arterial Stiffness in Renal Transplant Recipients

Serum Paraoxonase 1 Activity Predicts Arterial Stiffness in Renal Transplant Recipients

The Carotid-Femoral (Aortic) Pulse Wave Velocity and Paraoxonase 1 Activity: Review

Assessment of Arterial Stiffness with Pulse Wave Velocity or Augmentation Index: Which Method is the Best?: Scientific Letter

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