Assessment of long-term risks of secondary cancer in paediatric patients with brain tumours after boron neutron capture therapy

Zhang, Xinxin; Geng, Changran; Tang, Xiaobin; Bortolussi, Silva; Shu, Diyun; Gong, Chunhui; Yang, Han; Wu, S. L.

doi:10.1088/1361-6498/ab29a3

Cited by 9 publications

(7 citation statements)

References 30 publications

(43 reference statements)

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“…When comparing neutron beam geometries, the authors concluded that the lifetime attributable risk of secondary malignancy was lower with posterior-to-anterior arrangement compared to right-lateral and top-to-bottom. Younger patients and female patients also had higher risks of secondary malignancy (89). In Japan, only 1 out of 180 patients treated for malignant brain tumors since 1968 developed multiple radiation-induced meningiomas in the treatment field (90).…”

Section: Pediatricsmentioning

confidence: 99%

Boron Neutron Capture Therapy: A Review of Clinical Applications

et al. 2021

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Boron neutron capture therapy (BNCT) is an emerging treatment modality aimed at improving the therapeutic ratio for traditionally difficult to treat tumors. BNCT utilizes boronated agents to preferentially deliver boron-10 to tumors, which, after undergoing irradiation with neutrons, yields litihium-7 and an alpha particle. The alpha particle has a short range, therefore preferentially affecting tumor tissues while sparing more distal normal tissues. To date, BNCT has been studied clinically in a variety of disease sites, including glioblastoma multiforme, meningioma, head and neck cancers, lung cancers, breast cancers, hepatocellular carcinoma, sarcomas, cutaneous malignancies, extramammary Paget’s disease, recurrent cancers, pediatric cancers, and metastatic disease. We aim to provide an up-to-date and comprehensive review of the studies of each of these disease sites, as well as a review on the challenges facing adoption of BNCT.

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Section: Pediatricsmentioning

confidence: 99%

Boron Neutron Capture Therapy: A Review of Clinical Applications

et al. 2021

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“…In the same way, in patient contour images, voxels inside of patients are given a value of 1, and those outside of patients are given a value of 0. The 3D therapeutic dose for BNCT consists of four parts, that is, boron dose ( 10 B(n, α) 7 Li), fast neutron dose ( 1 H(n, n') 1 H), thermal neutron dose ( 14 N(n, p) 14 C), and gamma dose. Since fast neutron dose and thermal neutron dose are all caused by the protons and share the same relative biological effectiveness (RBE) factors, these two dose distributions are added and the result is named as proton dose in this study.…”

Section: Configuration Of 3d U-netmentioning

confidence: 99%

“…Given its high biological effectiveness, BNCT has unique advantages in the treatment of recurrent head and neck malignancies, glioblastoma, and melanomas, and the therapeutic effect has been demonstrated in some existing clinical cases. [7][8][9] An accurate BNCT treatment plan is the key to guiding the actual treatment. 10 Considering the complexity of neutron transport, current BNCT treatment planning systems (BNCT-TPSs) for example, NCT_Plan, 11 simulation environment for radiotherapy applications (SERA), 12 THORplan, 13 NeuCure system, 14 and JAEA computational dosimetry system, 15 all use the Monte Carlo (MC) method to evaluate the therapeutic dose.…”

Section: Introductionmentioning

confidence: 99%

Use of a neural network‐based prediction method to calculate the therapeutic dose in boron neutron capture therapy of patients with glioblastoma

et al. 2023

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Background: Boron neutron capture therapy (BNCT) is a binary radiotherapy based on the 10 B(n, α) 7 Li capture reaction. Nonradioactive isotope 10 B atoms which selectively concentrated in tumor cells will react with low energy neutrons (mainly thermal neutrons) to produce secondary particles with high linear energy transfer, thus depositing dose in tumor cells. In clinical practice, an appropriate treatment plan needs to be set on the basis of the treatment planning system (TPS). Existing BNCT TPSs usually use the Monte Carlo method to determine the three-dimensional (3D) therapeutic dose distribution, which often requires a lot of calculation time due to the complexity of simulating neutron transportation. Purpose: A neural network-based BNCT dose prediction method is proposed to achieve the rapid and accurate acquisition of BNCT 3D therapeutic dose distribution for patients with glioblastoma to solve the time-consuming problem of BNCT dose calculation in clinic. Methods: The clinical data of 122 patients with glioblastoma are collected.Eighteen patients are used as a test set, and the rest are used as a training set. The 3D-UNET is constructed through the design optimization of input and output data sets based on radiation field information and patient CT information to enable the prediction of 3D dose distribution of BNCT. Results: The average mean absolute error of the predicted and simulated equivalent doses of each organ are all less than 1 Gy. For the dose to 95% of the GTV volume (D 95 ), the relative deviation between predicted and simulated results are all less than 2%. The average 2 mm/2% gamma index is 89.67%, and the average 3 mm/3% gamma index is 96.78%. The calculation takes about 6 h to simulate the 3D therapeutic dose distribution of a patient with glioblastoma by Monte Carlo method using Intel Xeon E5-2699 v4, whereas the time required by the method proposed in this study is almost less than 1 s using a Titan-V graphics card. Conclusions: This study proposes a 3D dose prediction method based on 3D-UNET architecture in BNCT, and the feasibility of this method is demonstrated. Results indicate that the method can remarkably reduce the time required for calculation and ensure the accuracy of the predicted 3D therapeutic dose-effect. This work is expected to promote the clinical development of BNCT in the future.

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“…44 Glioblastomların tedavisinde bor bileşiklerinin kullanılmasıyla birlikte Bor Nötron Yakalama Tedavisi [Boron Neutron Capture Therapy (BNCT)] ile bor bileşiklerinin sentezine odaklanan çalışmaların sayısı artmıştır. [45][46][47][48] Düşük molekül ağırlıklı bor içeren ilaçlar olan borfenilalanin ve sodyum borkaptat beyin tümörlerinin tedavisinde kullanılmaya başlamıştır. 46 BNCT metodu güncel olarak kanser tedavilerinde kullanılmaya başlanmıştır.…”

Section: Beyi̇n Tümörleri̇unclassified

“…Bu tedavinin en önemli artısı, ameliyatın riskli olduğu kanser hastaları için bir umut olmasıdır. [48][49][50][51]…”

Section: Beyi̇n Tümörleri̇unclassified

Boron and Health

Söğüt¹,

Acar²

2020

J Lit Pharm Sci

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Doğada borat ve borik asit formu ile su ve toprakta bulunan borun, yakın zamana kadar zehirleyici etkileri daha yaygın olarak bilinse de 1997 yılından beri beslenme ve klinikte önemli rolü gündeme gelmiştir. 1,2 Kuruyemiş (fındık, ceviz, yer fıstığı, badem), meyve (ananas, vişne, üzüm, avokado, kayısı, şeftali) ve sebzelerde (brokoli, havuç, taze fasulye) bulunur. [2][3][4] Bölgesel açıdan farklılıklar gösterse de genel olarak günlük bor alımı 1-7 mg olarak bildirilmiştir. 5Bor, insan vücuduna beslenme, solunum ve sabun, deterjan, kozmetik yolu ile deriden girer. Deriden geçiş, herhangi bir yara yoksa ihmal edilebilir düzeydedir. Borun %85-90'ı, vücuda alındıktan kısa süre sonra değişmeden idrarla atılır, ancak %10-15'lik kısmı boratlar hâlinde bağırsaklardan emilir ve beyin-omurilik sıvısı, kemik, beyin, karaciğer ve yağ dokularında birikir. 4,5 ÖZET Sağlıklı canlıların metabolizmalarında önemli rolü olan bor, bir mikrobesindir. Borun insan sağlığına olan etkilerini özetlersek; (1) Kemiklerin yapısının korunması, büyümesi ve bakımı için önemlidir; (2) Kalsiyum, magnezyum, fosfor ve D vitamini gibi bazı vücut minerallerinin düzenlenmesinde rol alır; (3) Vücudun östrojen ve testosteron kullanımını etkiler; (4) Anti-inflamatuar etki gösterir ve romatoid artrit ile ilişkilidir; (5) Süperoksid dismutaz, katalaz ve glutatyon peroksidaz gibi antioksidan enzimlerin düzeylerini artırır; (6) Elektriksel beyin aktivitesini, bilişsel performansı ve yaşlılarda kısa-dönem hafızayı geliştirir; (7) Yara iyileştirici ve antimikrobiyal etkileri vardır; (8) Prostat, akciğer, meme kanserleri, beyin tümörleri üzerinde koruyucu ve tedavi edici etkileri olduğu bildirilmiştir. Dünya Sağlık Örgütünce sağlıklı erişkin bir bireyin beslenme ile alabileceği bor miktarı 1-13 mg olarak belirlenmiştir. Çeşitli kuruyemişler, baklagiller, meyve ve sebzeler bor açısından zengindir. Osteoporoz, osteoartrit, meme, prostat, akciğer kanserli veya riski olan, yeterli meyve ve sebze tüketmeyen kişilere bor takviyeli beslenme uygulandığında, bu hastalıklarla ilgili olumlu sonuçlar alındığı bildirilmiştir. Aşırı dozda bor alınması durumunda, erişkinlerde baş ağrısı, kusma, ishal, psikolojik sorunlar; çocuklarda havale ve beyin zarı tahribi yapabileceği rapor edilmiştir. Ancak öldürücü dozu aşmak çok zordur. Bu derleme; borun insan sağlığı üzerindeki belirgin etkilerini ve borun yeni tedavilerde kullanımını kapsayan çalışmaları bir araya getirmeye odaklanmıştır. Anah tar Ke li me ler:Bor; sağlık; fayda; terapötik kullanım ABS TRACT Boron, which plays an important role in the metabolism of healthy living organisms, is a micronutrient. To summarize the effect of boron on human health; (1) Is essential for the protection, growth and maintenance of bone; (2) Plays a role in the regulation of some body minerals such as calcium, magnesium, phosphorus and vitamin D;(3) Impacts the body's use of estrogen, testosterone (4) Has anti-imflammatory effect and related with romatoid arthrit; (5) Raises levels of antioxidant enzymes, such as superoxide dismutase, catalas...

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Assessment of long-term risks of secondary cancer in paediatric patients with brain tumours after boron neutron capture therapy

Cited by 9 publications

References 30 publications

Boron Neutron Capture Therapy: A Review of Clinical Applications

Boron Neutron Capture Therapy: A Review of Clinical Applications

Use of a neural network‐based prediction method to calculate the therapeutic dose in boron neutron capture therapy of patients with glioblastoma

Boron and Health

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