Assessment of localized therapeutic effect for prolonged release biodegradable implants loaded with 5-Fluorouracil on rats with induced liver cancer

In vivo pharmacokinetic and tissue distribution investigation of sustained-release cisplatin implants in the normal esophageal submucosa of 12 beagle dogs

“…Locoregional chemotherapy, especially intratumoral administration, has been shown to result in high antitumor CDDP efficacy and to maintain a high concentration of CDDP at the tumor site [8,9]. Intratumoral administration of small molecular weight anticancer drugs such as CDDP may, however, cause side effects because of short drug retention times in tumors and rapid drug distribution into the whole body via the bloodstream [10].…”