Assessment of local genotoxic effects of formaldehyde in humans measured by the micronucleus test with exfoliated buccal mucosa cells

Speit, Günter; Schmid, Oliver; Fröhler-Keller, Manuela; Lang, Isabelle; Triebig, Gerhard

doi:10.1016/j.mrgentox.2006.10.013

Cited by 38 publications

(28 citation statements)

References 16 publications

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“…In humans, FA exposure is associated with an increase in the frequency of MN in buccal epithelium cells (Burgaz et al, 2002;Speit et al, 2006Speit et al, , 2007b, as corroborated by the results presented here. Suruda el al.…”

Section: Discussionsupporting

confidence: 89%

Genotoxicity Biomarkers: Application in Histopathology Laboratories

Ladeira¹,

Viegas²,

Carolino³

et al. 2012

Biomarker

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Section: Discussionsupporting

confidence: 89%

Genotoxicity Biomarkers: Application in Histopathology Laboratories

Ladeira¹,

Viegas²,

Carolino³

et al. 2012

Biomarker

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“…In humans, formaldehyde exposure is associated with an increase in the frequency of MN in buccal epithelium cells (Burgaz et al, 2002;Speit et al, 2007) as corroborated by the results presented here. Suruda el al.…”

Section: Discussionsupporting

confidence: 88%

Genotoxic Effects of Exposure to Formaldehyde in Two Different Occupational Settings

Viegas¹,

Ladeira²,

Gomes³

et al. 2012

Carcinogen

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“…This protective mechanism of the organism prevents the proliferation of damaged cells. 31 The analysis of oral epithelial cells also provides information on nuclear changes such as karyorrhexis, karyolysis, pyknosis, broken eggs, buds and binucleate cells. This study showed a higher frequency of cells in the mucosa of crack cocaine users exhibiting karyorrhexis.…”

Section: Discussionmentioning

confidence: 99%

Genotoxic and Cytotoxic Potential of Smoke Crack Cocaine on the Epithelium of the Human Oral Mucosa

et al. 2016

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Crack cocaine is an illicit drug derived from cocaine. It can produce some damages to the lungs and oral cavity. Objective: The aim of this study was to analyze the frequency of micronuclei and some nuclear alterations in epithelial cells of crack cocaine users. Methods: Oral smears were collected from clinically normal-appearing buccal mucosa exfoliative cytology of 30 individuals (15 crack cocaine users and 15 controls). Results: Crack cocaine users consumed about 3.8 grams per day and the time consumption of the drug was of 6.4 +3.3 years. The prevalence of micronuclei, binucleated cells, broken egg cells, budding cells, picnosis, karyolysis, and karyorrhexis was determined. The frequencies of micronuclei for case and control groups were, 2.87+3.46 and 0.57+1.6 (p=0.018) respectively. No statistical difference was observed for binucleated cells, broken egg cells, budding cells, picnosis, and karyolysis. The frequency of karyorrhexis was significantly increased on crack cocaine users than controls (54.07+38.58 and 24.87+23.97, p=0.001). Conclusion: Smoke crack might have a cytotoxic and genotoxic effects to the oral mucosa due to increased frequency of micronuclei and karyorrhexis. Thus, individuals who used crack cocaine in the long term need to be frequently examined in order to prevent neoplastic transformation.

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Assessment of local genotoxic effects of formaldehyde in humans measured by the micronucleus test with exfoliated buccal mucosa cells

Cited by 38 publications

References 16 publications

Genotoxicity Biomarkers: Application in Histopathology Laboratories

Genotoxicity Biomarkers: Application in Histopathology Laboratories

Genotoxic Effects of Exposure to Formaldehyde in Two Different Occupational Settings

Genotoxic and Cytotoxic Potential of Smoke Crack Cocaine on the Epithelium of the Human Oral Mucosa

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