Assessment of local carotid stiffness in seronegative and seropositive rheumatoid arthritis

Aslan, Abdullah Nabi; Özcan, Ayşenur Şirin; Erten, Şükran; Alsancak, Yakup; Durmaz, Tahir

doi:10.1080/14017431.2017.1343493

Cited by 7 publications

(6 citation statements)

References 29 publications

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“…As seen in this study, age, SBP, and BMI have been previously identified as independent predictors of arterial stiffness in RA patients 21,23,24,39 . However, the effect of age on PWV, mediated by SBP and BMI, has not been previously described.…”

Section: Discussionsupporting

confidence: 66%

“…Some case-control studies reported increased arterial stiffness in RA patients 11–13 . In these studies, associations with variables that are characteristic of the disease such as disease duration 14,15 , inflammatory variables 16–19 , and disease activity 16,20–22 have been demonstrated, although arterial stiffness has also been correlated with age 19,23,24 and SBP 23–25 . There are few published studies that have evaluated distensibility as a marker of arterial stiffness in RA 26 , and the results of these studies are similar to those obtained for PWV and AIx.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of arterial stiffness variables in patients with rheumatoid arthritis: A mediation analysis

Taverner

Paredes

Ferré

et al. 2019

Sci Rep

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We aimed to study arterial stiffness variables in patients with rheumatoid arthritis (RA), specifically considering their associations with path model mediation analysis. We examined arterial stiffness expressed by the pulse wave velocity (PVW), augmentation index (AIx), distensibility, and clinical and biochemical characteristics in a cohort of 214 RA patients. Variable associations were analysed using multivariate linear regression analysis. We also used path model mediation analysis for PWV variable. Our results indicate that age, systolic blood pressure (SBP), and body mass index (BMI) were significantly associated with PWV, and collectively accounted for 32% of PWV variability. The parallel mediation analysis showed that SBP and BMI accounted for 21% and 7% (a total of 28%) of the total effect of age on PWV, respectively, indicating a partial mediation effect. The associated variables with AIx were age and tender joint count, while those with distensibility were BMI and sex, overall accounting for 16.5% and 4.7% of the variation in AIx and distensibility, respectively. We observed no associations of arterial stiffness with inflammatory variables, disease activity and duration, or cholesterol levels. In conclusion, in our population of RA patients, age is the most important variable that determines the increase in PWV. We have also shown that a significant proportion of the negative effects of age on PWV occurs through increases in SBP and BMI. In our study, lipid and inflammation variables were not associated with an increase in arterial stiffness.

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Section: Discussionsupporting

confidence: 66%

Section: Introductionmentioning

confidence: 99%

Assessment of arterial stiffness variables in patients with rheumatoid arthritis: A mediation analysis

Taverner

Paredes

Ferré

et al. 2019

Sci Rep

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“…The sample size calculation was based on studies in which the PWV values and differences (to assess vascular stiffness) between patients with RA and controls without RA were estimated ( 14 , 15 , 17 ). A power of 80% and a type I error of 0.05 were assumed.…”

Section: Methodsmentioning

confidence: 99%

“…In fact, there are studies evaluating the PWV in RA but not many that assess VA, and few or none that analyze VA based on PWV in RA patients (14)(15)(16)(17)(18)(19). For instance, Mong et al used the coronary calcium score (CCS) as a non-invasive method to calculate arterial age and cardiovascular risk stratification.…”

Section: Introductionmentioning

confidence: 99%

Vascular Age, Metabolic Panel, Cardiovascular Risk and Inflammaging in Patients With Rheumatoid Arthritis Compared With Patients With Osteoarthritis

Rodríguez-Vargas

Santos-Moreno

Rubio-Rubio

et al. 2022

Front. Cardiovasc. Med.

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IntroductionThe risk of cardiovascular disease (CVD) in patients with rheumatoid arthritis (RA) is 1.5–2 times higher than the general population. The fundamental risk factor for CVD is age, related to alterations at the arterial level. The aim of the study was to compare vascular age (VA) in RA patients under a strict treat-to-target (T2T) strategy with Osteoarthritis (OA) patients without strict follow up and to assess the influence of inflammaging (chronic, sterile, low-grade inflammation related to aging) and metabolic markers on VA.Materials and MethodsThis was an analytical cross-sectional study. Patients with RA (under a strict a T2T strategy) and OA patients without strict clinical follow-up were included. Patients with a history of uncontrolled hypertension, CVD, and/or current smoking were excluded. Sociodemographic, physical activity, and toxic exposure data were obtained. Waist-hip ratio and body mass index (BMI) were measured. DAS-28 (RA) and inflammatory markers, lipid profile, and glycaemia were analyzed. Pulse wave velocity (PWV) was measured (oscillometric method, Arteriograph-TensioMed®). VA was calculated based on PWV. Eleven components of inflammaging [six interleukins, three metalloproteinases (MMP), and two tissue inhibitors of metalloproteinases (TIMP)] were evaluated (Luminex® system). Univariate and bivariate analyzes (Mann Whitney U and chi-square) and correlations (Spearmans Rho) were done to compare the two groups.ResultsA total of 106 patients (74% women) were included, 52/RA and 54/OA. The mean age was 57 (Interquartile range - IQR 9 years). The BMI, waist circumference, and weight were higher in patients with OA (p < 0.001). RA patients had low disease activity (DAS-28-CRP). There were no differences in VA, inflammaging nor in PWV between the two groups. VA had a positive, but weak correlation, with age and LDL. In group of RA, VA was higher in those who did not receive methotrexate (p = 0.013). LDL levels correlated with MMP1, TIMP1, and TIMP2.ConclusionsWhen comparing RA patients with low levels of disease activity with OA patients with poor metabolic control, there are no differences in VA. Furthermore, methotrexate also influences VA in RA patients. This shows that implemented therapies may have an impact on not only the inflammatory state of the joint but also CVD risk.

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“…Although it can affect anyone at any age, the peak onset is between the ages of 50 and 59 [2]. RA patients have an increased risk of cardiovascular (CV) disease occurring due to the inflammatory nature of the disease leading to higher morbidity and mortality rates [3][4][5]. CV events associated with RA range in a spectrum of severity.…”

Section: Introductionmentioning

confidence: 99%

Increased Risk of Cardiovascular Diseases in Rheumatoid Arthritis: A Systematic Review

Farhat¹,

Irfan²,

Muthiah³

et al. 2022

Cureus

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Rheumatoid arthritis (RA) is an autoimmune condition in which the body's joints are attacked by the immune system, leaving the patient disabled in severe cases, with irreversible joint damage and a lower quality of life. RA patients are more likely to develop cardiovascular (CV) disease, which increases their risk of morbidity and mortality. This study systematically reviews various CV diseases that might occur with RA including heart failure (HF), coronary artery disease, acute coronary syndrome, ischemic heart disease, stroke, cardiac death, venous thromboembolism, and valvular diseases. The relation between these complications and RA is specifically assessed. Systematic search was carried out on literature reporting the risk of each of the CV diseases in RA patients from databases in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The databases searched were MEDLINE (through PubMed) and Google Scholar using a combination of keywords and medical subject headings (MeSH). Our keywords were mainly "cardiovascular diseases" and "arthritis and rheumatoid". We found a total of 33 articles reporting each CV comorbidity. Interestingly, a wide spectrum of CV diseases is reported in patients with RA. Many tools were implemented in the diagnosis of each disease such as carotid intima-media thickness for atherosclerosis and echocardiography for HF. We confirmed that RA is associated with an increased risk of different CV events, and prophylactic measures should be implemented.

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Assessment of local carotid stiffness in seronegative and seropositive rheumatoid arthritis

Abstract: RA per se is sufficient to cause arteriosclerosis in the absence of classical CV risk factors. However, arterial hypertrophy is only increased in seronegative patients but not in seropositive group.

Cited by 7 publications

References 29 publications

Assessment of arterial stiffness variables in patients with rheumatoid arthritis: A mediation analysis

Assessment of arterial stiffness variables in patients with rheumatoid arthritis: A mediation analysis

Vascular Age, Metabolic Panel, Cardiovascular Risk and Inflammaging in Patients With Rheumatoid Arthritis Compared With Patients With Osteoarthritis

Increased Risk of Cardiovascular Diseases in Rheumatoid Arthritis: A Systematic Review

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