Assessment of Liver Function

Mukherjee, Sandeep; Gollan, John L.

doi:10.1002/9781444341294.ch2

Cited by 10 publications

(17 citation statements)

References 63 publications

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“…In this study, all groups presented mean AST values, lower than the reference values in the literature (39-92 U/l) 27 , but were not statistically significant when compared to each other. There was a decrease in ALT in the 14-day control group, already mentioned by other authors 20 .…”

Section: Discussionsupporting

confidence: 78%

“…The effect of TLBP on hepatic regeneration after HP stimulates a significant improvement of hepatic regeneration, favorable for the formation of new hepatocytes, mesenchymal stem cells and angiogenesis in regeneration in rats 22 , improving the stability of mitochondrial function, increasing the rate of respiratory control, suggesting delay of hepatocellular overload of the remaining liver 4 , 7 . TLBP can lead to good clinical performance, simple, fast and easy to perform, promoting an improvement in the regenerative capacity of the organ after HP, by increasing the expression of the hepatocyte growth factor, exerting an accelerating role in the process of liver regeneration in rats, regardless of the penetration depth of the laser 3 , 20 .…”

Section: Introductionmentioning

confidence: 99%

“…Studies that observe liver function through liver function tests, through analysis of serum levels of aminotransferases, gamma glutamyltransferase, alkaline phosphatase and bilirubin, show that the use of TLBP in the hepatic regeneration process does not cause liver damage in addition to the surgical procedure on livers of healthy rats 2 , 17 , 20 , 21 .…”

Section: Introductionmentioning

confidence: 99%

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Functional and Cellular Evaluation of the Liver After Low-Power Laser Stimulation During Surgery

Godoy

Gerson

Pinto

et al. 2017

ABCD, arq. bras. cir. dig.

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Background: Partial hepatectomy is a surgical intervention of the liver that can trigger its regenerative process, where the residual lobes deflagrate a compensatory hyperplasia, causing its restoration almost to the original volume. Nevertheless, depending on the extent of liver damage its regeneration might be impaired. The low-power laser has been studied with beneficial results. Aim: To investigate the possible functional and mutagenic damage arising from the use of low-power laser used in liver regeneration after partial hepatectomy. Methods: Fifteen male adult Wistar rats were hepatectomizated in 70% and laser irradiated or not with dose of 70 J/cm2, 650 nm, 100 mW, directly on the remaining liver, during the perioperative period. These animals were divided into four groups: G1 (control, 7 days); G2 (laser, 7 days); G3 (control, 14 days); G4 (laser, 14 days). Were analyzed the liver weight; number of hepatocytes; deposition of collagen fibers; liver function tests: serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, gamma glutamyl transferase, bilirubin and micronucleus test in peripheral blood erythrocyte. Results: The liver weight was greater in G3 and G4 (p=0.001 and p=0.002) compared to other groups. The deposition of collagen fibers in G1 was statistically higher than the other groups (p=0.01). In tests of liver function and micronucleus test was not found significant differences between the studied groups. Conclusion: Low-power laser stimulation did not cause loss of liver function or mutagenic damage.

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Section: Discussionsupporting

confidence: 78%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Functional and Cellular Evaluation of the Liver After Low-Power Laser Stimulation During Surgery

Godoy

Gerson

Pinto

et al. 2017

ABCD, arq. bras. cir. dig.

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“…Immunoglobulin G (IgG) is synthesized by B cells, and IgG levels are elevated in patients with liver cirrhosis as a non‐specific response to bacteremia, increased Ig production, or portal systemic shunting. Increased numbers of plasma cells in the bone marrow and liver may be the source of increased IgG . Previous studies suggested an association between post‐transplant Ig levels and the development of infection in solid organ transplantation .…”

Section: Methodsmentioning

confidence: 99%

Decreased immunoglobulin G levels after living‐donor liver transplantation is a risk factor for bacterial infection and sepsis

Yoshizumi

Shirabe

Ikegami

et al. 2014

Transplant Infectious Dis

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“…As the liver plays a principal role in metabolism, several metabolic functions have been shown to deteriorate with the progression of CLDs ( 8 ). Amino acid imbalance is one such metabolic disorder in patients with CLD ( 9 ), and previous studies, including from our group, showed that a decreased BTR value was related to the severity of liver fibrosis in CLD patients ( 5 , 10 , 11 ).…”

Section: Discussionmentioning

confidence: 99%

Improvement in the Amino Acid Imbalance in Hepatitis C Virus Infected Patients After Viral Eradication by Interferon Treatment

et al. 2016

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BackgroundIn patients with chronic liver diseases (CLDs), hepatitis C virus (HCV) infection in particular may cause various metabolic disorders. We previously reported that the value of the ratio of branched-chain amino acids to tyrosine (BTR) decreased with the progression of liver fibrosis.ObjectivesWe investigated the changes in clinical variables during interferon (IFN) treatment and assessed whether HCV eradication improved the amino acid imbalance in HCV infected patients.Patients and MethodsWe retrospectively collected the clinical data of HCV-related CLD patients whose BTR values had been measured both pre- and post-IFN treatment. A total of 17 patients with a sustained viral response (SVR) (mean observational period: 1085.0 days) and 19 patients without an SVR (Non-SVR) (mean observational period: 1002.5 days) were studied.ResultsIn patients with an SVR, the serum levels of aminotransferases were decreased after HCV eradication. Although general liver functional tests (albumin and total bilirubin) did not significantly change, the BTR values significantly increased. However, in patients without an SVR, an improvement in the BTR value was not observed after IFN treatment.ConclusionsHCV eradication can improve the amino acid imbalance in HCV infected patients.

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Assessment of Liver Function

Cited by 10 publications

References 63 publications

Functional and Cellular Evaluation of the Liver After Low-Power Laser Stimulation During Surgery

Functional and Cellular Evaluation of the Liver After Low-Power Laser Stimulation During Surgery

Decreased immunoglobulin G levels after living‐donor liver transplantation is a risk factor for bacterial infection and sepsis

Improvement in the Amino Acid Imbalance in Hepatitis C Virus Infected Patients After Viral Eradication by Interferon Treatment

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