Assessment of Liver Fibrosis With Elastography Point Quantification vs Other Noninvasive Methods

Conti, Fabio; Serra, Carla; Vukotic, Ranka; Felicani, Cristina; Mazzotta, Elena; Gitto, Stefano; Vitale, Giovanni; D’Errico, Antonietta; Andreone, Pietro

doi:10.1016/j.cgh.2018.06.027

Cited by 24 publications

(34 citation statements)

References 36 publications

(33 reference statements)

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“…In the last few years, different producers of ultrasound systems (Hitachi, Canon, General Electric) developed technologies able to quantify steatosis and fibrosis [17][18][19][20][21][22]. Some of them have the option to evaluate also viscoelastic tissue properties for the assessment of inflammation (Hitachi, Canon).…”

Section: Introductionmentioning

confidence: 99%

Quantification of Steatosis and Fibrosis using a new system implemented in an ultrasound machine

et al. 2020

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Aim: The study compared the usefulness of 2D-SWE and attenuation measurements obtained using Aplio i800 from Canon together with Transient Elastography (TE) and the Controlled Attenuation Parameter (CAP) as the reference method.Material and methods: We included 112 consecutive adults with reliable LS measurements, 44 healthy subjects and 68 subjects with chronic hepatopathies in whom liver stiffness (LS) and steatosis were evaluated in the same session employing two elastography techniques: Transient Elastography (TE) with Controlled Attenuation Parameter (CAP) implemented on the FibroScan® 530 Compact system and Two Dimensional Shear Wave Elastography (2D-SWE) with Attenuation Imaging (ATI) installed on the Aplio i800 series ultrasound system. Reliable measurements were defined as the median value of 10, respectively 5 valid LS measurements for TE and 2D-SWE, with an interquartile range interval/median ratio (IQR/M) <30%.Results: A very strong positive correlation was found between LS values obtained by TE and 2D-SWE: r=0.88, p<0.0001 and between the attenuation coefficients of steatosis obtained by CAP and ATI, r=0.81, p<0.0001. The best cut-off values by 2DSWE for predicting different stages of liver fibrosis were: for F≥2 - 7.9 kPa and F=4 - 11.7 kPa. Regarding steatosis, the best ATI cut-off values were: for S≥1 - 0.79 dB/cm/mHz and for S3 - 0.86 dB/cm/mHz.Conclusion: 2D-SWE and ATI measurements with the new system strongly correlated with TE and CAP results.

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Section: Introductionmentioning

confidence: 99%

Quantification of Steatosis and Fibrosis using a new system implemented in an ultrasound machine

et al. 2020

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“…According to our study, an LS limit value or 5 kPa was discovered to have very good sensitivity and specificity in detecting NAFLD and each 0.5 kPa increase in LS also increased the risk of NAFLD by 2.12 fold. (8,(30)(31)(32)(33)(34)(35). First among these studies are limit value studies in healthy controls in 2013 (30), followed by chronic viral hepatitis studies (8,(31)(32)(33)(34)(35).…”

Section: Discussionmentioning

confidence: 99%

“…(8,(30)(31)(32)(33)(34)(35). First among these studies are limit value studies in healthy controls in 2013 (30), followed by chronic viral hepatitis studies (8,(31)(32)(33)(34)(35). The most recent retrospective study of 2018 evaluated the outcome of biopsy in different chronic liver disease patients and only 4 NAFLD patients were included in the study (35).…”

Section: Discussionmentioning

confidence: 99%

“…First among these studies are limit value studies in healthy controls in 2013 (30), followed by chronic viral hepatitis studies (8,(31)(32)(33)(34)(35). The most recent retrospective study of 2018 evaluated the outcome of biopsy in different chronic liver disease patients and only 4 NAFLD patients were included in the study (35). In this last study, it has been reported that the ElastPQ technique predicts very well the presence and degree of LF, such as TE (35).…”

Section: Discussionmentioning

confidence: 99%

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The Role of Liver Elastography Point Quantification in the Assessment of Fibrosis in Non-Alcoholic Fatty Liver Disease and Comparison with Other Non-Invasive Methods

Demirtaş¹,

Kocaer²,

Sümbül³

2020

Akd Med J

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Objective: The aim of this study was to determine the availability of a new liver stiffness (LS) measurement, the elastography point quantification (ElastPQ) method, in non-alcoholic fatty liver disease (NAFLD) and to compare it with other noninvasive Liver fibrosis (LF) investigations. Material and Methods: A total of 108 patients with or without NAFLD were included in this study. LS measurement was done by the ElastPQ method. Noninvasive LF investigations; the AST/ Platelet-ratio-index (APRI), Fibrosis-4 (FIB-4) index, NAFLD fibrosis score, AST/ALT ratio and BARD score were evaluated. Results: Liver size, LS, APRI, FIB-4 index, NAFLD fibrosis score, AST/ALT ratio and BARD score were all significantly higher in NAFLD patients. It was determined that only LS among these parameters independently determined the NAFLD status. It was found that each 0.5-kPa increase in LS increased the risk of having NAFLD 2.12 fold. When the ROC analysis was performed for the NAFLD determination of the LS value, it was determined that the area under the ROC curve was 0.967, and when the limit value for LS was taken as 5-kPa, the risk of having NAFLD was determined with 88.9% sensitivity and 94.4% specificity. Conclusion: The LS value obtained by ElastPQ has high diagnostic accuracy for NAFLD and performs better than other noninvasive laboratory methods in the assessment of NAFLD. At the same time, the LS value is closely related to the FIB-4 index, NAFLD fibrosis score and BARD score.

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“…A high ALBI-FIB-4 score was associated with a high incidence of postoperative recurrence and mortality. proposed to assess the severity of liver fibrosis (8,9). The fibrosis-4 index (FIB-4) is a noninvasive method used to assess the severity of fibrosis in patients that considers four parameters: age, platelet counts, and aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels (10).…”

Section: Discussionmentioning

confidence: 99%

The combination of the preoperative albumin-bilirubin grade and the fibrosis-4 index predicts the prognosis of patients with hepatocellular carcinoma after liver resection

Zhang

Luo

et al. 2019

BST

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Assessment of Liver Fibrosis With Elastography Point Quantification vs Other Noninvasive Methods

Cited by 24 publications

References 36 publications

Quantification of Steatosis and Fibrosis using a new system implemented in an ultrasound machine

Quantification of Steatosis and Fibrosis using a new system implemented in an ultrasound machine

The Role of Liver Elastography Point Quantification in the Assessment of Fibrosis in Non-Alcoholic Fatty Liver Disease and Comparison with Other Non-Invasive Methods

The combination of the preoperative albumin-bilirubin grade and the fibrosis-4 index predicts the prognosis of patients with hepatocellular carcinoma after liver resection

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