Assessment of Left Ventricular Systolic and Diastolic Function Using ECG-Gated Technetium-99m Tetrofosmin Myocardial Perfusion SPECT

Mizunobu, Mayumi; Sakai, Jun; Sasao, Hisataka; Murai, Hiroshi; Fujiwara, Hidetoshi

doi:10.1536/ihj.54.212

Cited by 16 publications

(17 citation statements)

References 14 publications

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“…The mean value for PFR of hypertensive and normotensive patients in current study was higher than the mean value of PFR reported in prior studies for patients with mild diastolic dysfunction and normal study population (14,17). Akincioglu et al (17) assessed the values of diastolic function parameters in 90 patients with normal exercise gated SPECT, and no history of hypertension, diabetes, rest electrocardiogram abnormality, or known cardiac disease, and reported a mean normal value for PFR of 2.62 ± 0.46 EDV/s.…”

Section: Discussioncontrasting

confidence: 86%

“…Mizunobu et al (14) reported similar mean values of 1/3 MFR for patients with mild diastolic dysfunction, and patients with normal diastolic function estimated by ultrasound echocardiography (UCG) (1.01 ± 0.35 EDV/s, and 1.43 ± 0.37 EDV/s respectively). Furthermore, the 1/3 MFR of patients with mild diastolic dysfunction estimated by UCG was significantly lower than that of patients with normal diastolic function.…”

Section: Discussionmentioning

confidence: 82%

“…The evaluation of LV diastolic function as part of routine echocardiographic testing is recommended by the current guidelines of the American Society of echocardiography and the European Association of cardiovascular imaging (12). Several reports have shown that Electrocardiography (ECG)-gated single-photon emission computed tomography (SPECT) was found to have good correlation with echocardiography for assessment of diastolic and systolic LV function and volumes (13)(14)(15)(16). In clinical practice, ECG-gated SPECT may be a good alternative for patients with limitations for optimal echocardiography visualization (13), and the stability of diastolic function variables estimated by ECG-gated SPECT has been reported recently (17).…”

Section: Introductionmentioning

confidence: 99%

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The impact of hypertension on diastolic left ventricular function, evaluated by quantitative ECG-gated myocardial perfusion SPECT

Sayed

El-Tayeb²,

Farghaly

2015

The Egyptian Journal of Radiology and Nuclear Medicine

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Background: Abnormality of left ventricular (LV) diastolic function is frequently the earliest indicator of LV dysfunction in many diseases, including coronary artery disease (CAD), and hypertension. Electrocardiography (ECG)-gated technetium (Tc)-99 m tetrofosmin singlephoton emission computed tomography (SPECT) has been reported to be a useful method for evaluation of LV function. Objectives: The purpose of this study was to assess the impact of hypertension on diastolic left ventricular function using ECG-gated Tc-99m tetrofosmin SPECT. Methods: Thirty consecutive patients with normal exercise myocardial perfusion and normal LV systolic function, were studied out of 233 patients underwent ECG-gated Tc-99m tetrofosmin SPECT at our institution between January 2012 and December 2013. Patients were divided into two groups according to the presence or absence of systemic hypertension (blood pressure P140/ 90 mm Hg on P3 measurements or treatment with antihypertensive medication). Parameters of diastolic LV function were assessed. Results: Of the studied 30 patients, 19/30 (63%) had hypertension. There was no difference with respect to age, gender, LV end-diastolic volume (EDV), LV end-systolic volume (ESV), and LV ejection fraction values obtained by quantitative gated SPECT between patients with and without hypertension. The first-third mean filling rate (1/3 MFR), peak filling rate (PFR) of patients with hypertension (1.22 ± 0.38, 2.83 ± 1.10 EDV/s) were lower than those of patients without This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). hypertension (1.54 ± 0.30, 2.90 ± 0.35 EDV/s), and the time to peak filling (TTPF) of patients with hypertension (199.42 ± 68.34 ms) was higher than TTPF of patients without hypertension (164.90 ± 36.39 ms). Conclusions: Quantitative ECG-gated Tc-99m tetrofosmin SPECT reveals that hypertensive patients with preserved global LV systolic function may have significant changes in diastolic LV function. Gated myocardial perfusion SPECT reports are always lacking in these changes in diastolic function. We recommend inclusion of such changes in diastolic function in gated myocardial perfusion SPECT reports that can help in proper management of hypertensive patients.

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Section: Discussioncontrasting

confidence: 86%

Section: Discussionmentioning

confidence: 82%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The impact of hypertension on diastolic left ventricular function, evaluated by quantitative ECG-gated myocardial perfusion SPECT

Sayed

El-Tayeb²,

Farghaly

2015

The Egyptian Journal of Radiology and Nuclear Medicine

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“…Beyond their capabilities to characterize myocardial architecture, perfusion, viability, and function, noninvasive imaging modalities offer the added possibility to dynamically evaluate ventricular motion during the cardiac cycle by means of ECG-gated acquisitions 1,2. Such motion characterization is achieved through sequential target detection, cavity orientation, segmentation preprocessing, and motion analysis resulting in quantitative estimates of ventricular mechanical synchrony 3…”

Section: Introductionmentioning

confidence: 99%

Phase analysis of gated PET in the evaluation of mechanical ventricular synchrony: A narrative overview

Juárez-Orozco

Monroy-Gonzalez

Prakken

et al. 2019

Journal of Nuclear Cardiology

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Noninvasive imaging modalities offer the possibility to dynamically evaluate cardiac motion during the cardiac cycle by means of ECG-gated acquisitions. Such motion characterization along with orientation, segmentation preprocessing, and ultimately, phase analysis, can provide quantitative estimates of ventricular mechanical synchrony. Current evidence on the role of mechanical synchrony evaluation is mainly available for echocardiography and gated single-photon emission computed tomography, but less is known about the utilization of gated positron emission tomography (PET). Although data available are sparse, there is indication that mechanical synchrony evaluation can be of diagnostic and prognostic values in patients with known or suspected coronary artery disease-related myocardial ischemia, prediction of response to cardiac resynchronization therapy, and estimation of risk for adverse cardiac events in patients’ heart failure. As such, the evaluation of mechanical ventricular synchrony through phase analysis of gated acquisitions represents a value addition to modern cardiac PET imaging modality, which warrants further research and development in the evaluation of patients with cardiovascular disease.Electronic supplementary materialThe online version of this article (10.1007/s12350-019-01670-7) contains supplementary material, which is available to authorized users.

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“…[3] Radionuclide ventriculography (RNV) has long been used in the evaluation of systolic and diastolic functions of the left ventricle, and studies correlated with echocardiography have confirmed its value. [4] Currently, however, it is used less often and does not provide information about myocardial perfusion. MPS is an ideal method with which to provide diagnostic and prognostic information about myocardial perfusion effectively and at low cost.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of diastolic function in patients with normal perfusion and type 2 diabetes mellitus with gated single-photon emission computed tomography

2017

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Early identification of diastolic dysfunction of patients with diabetes is important in preventing cardiac events. In this study, we aimed to show that both myocardial perfusion and diastolic function parameters can be evaluated in diabetic patients with possible silent cardiac symptoms using gated single-photon emission computed tomography (G-SPECT). We examined eighty patients: Forty with and forty without diabetes. The patients were compared in terms of systolic and diastolic parameters obtained using G-SPECT. 99mTc-sestamibi was used to obtain 8-frame images in each cardiac cycle, with calculation of the left ventricular ejection fraction (LVEF), peak filling rate (PFR), mean filling rate during the first third of diastolic time (MFR/3), and time to peak filling (TTPF) using the QGS software. G-SPECT results were compared in forty diabetic and forty nondiabetic patients of similar age and sex. Of the diastolic function parameters, PFR was found to be lower in patients with than without diabetes (2.31 ± 0.68 vs. 2.76 ± 0.68, respectively; P = 0.004). The TTPF and MFR/3 in both groups were similar. PFR was negatively correlated with end-diastolic volume and end-systolic volume (ESV) and positively correlated with LVEF. This correlation was stronger in patients with diabetes. The diastolic parameter PFR, obtained using G-SPECT, was significantly lower in patients with than without diabetes. We believe that these parameters should be noted for the early diagnosis or prevention of heart disease in patients with a risk of diastolic dysfunction.

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Assessment of Left Ventricular Systolic and Diastolic Function Using ECG-Gated Technetium-99m Tetrofosmin Myocardial Perfusion SPECT

Cited by 16 publications

References 14 publications

The impact of hypertension on diastolic left ventricular function, evaluated by quantitative ECG-gated myocardial perfusion SPECT

The impact of hypertension on diastolic left ventricular function, evaluated by quantitative ECG-gated myocardial perfusion SPECT

Phase analysis of gated PET in the evaluation of mechanical ventricular synchrony: A narrative overview

Evaluation of diastolic function in patients with normal perfusion and type 2 diabetes mellitus with gated single-photon emission computed tomography

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