Assessment of left ventricular function in ischemic heart disease  The relation between pressure decay during the isovolumic relaxation phase and regional wall motion abnormality.

Takeuchi, Motoshi; Fujitani, Kazumasa; Kurogane, Keiji; Bai, Hong-Tai; Toda, Chuichi; Fukuzaki, Hisashi

doi:10.1253/jcj.48.961

Cited by 7 publications

(1 citation statement)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They concluded that impaired global diastolic filling may have resulted either from asynchronous LV regional diastolic function, which is a reversible manifestation of myocardial ischemia, or flora a reduction in coronary flow. Concerning LV wall motion, Takeuchi et al [19] pointed out that T was prolonged in patients with coronary artery disease, and that its value was closely related to the severity of the pacing-induced abnormalities in regional wall motion. They postulated that regional wall motion abnormalities mäy alter LV relaxation during acute ischemia in patients with coronary artery disease.…”

Section: V Filling During Early Diastole In Angina Pectorismentioning

confidence: 99%

Regional diastolic function in effort angina pectoris: Assessment with biplane left ventriculography

et al. 1995

View full text Add to dashboard Cite

To investigate left ventricular (LV) regional diastolic function in effort angina pectoris (AP), we performed left ventriculography in 14 patients with AP and isolated left anterior descending artery disease and in 9 normal subjects (N). LV volume (V), regional area (S) [anterior, apex, and inferior], and the first derivative of V and S (dV/dt, dS/dt) were derived from analysis of the left ventriculogram. Normalized peak filling rate (nPFR) and peak atrial filling rate (nPAFR) were derived from dV/dt. The ratio of filling volume to stroke volume during rapid filling and atrial contraction were defined as rapid filling fraction (RFF) and atrial filling fraction (AFF). Similarly, peak area changing rate (PACR), peak area changing rate during atrial contraction (PACRac), rapid area changing fraction (RACF), and atrial area changing fraction (AACF) were derived from S and dS/dt. We also calculated the time constant of LV relaxation (T), and LV global and regional compliance during atrial contraction [(dV/VdP)ac, (dS/SdP)ac]. The LV global diastolic function (T increases, nPFR decreases) was impaired in the angina patients. LV regional diastolic function (nPACR decreases, RACF decreases) was also impaired in the affected region of the AP group. While their rapid filling was impaired, nPACRac was maintained and AACF was increased in the affected region. Furthermore, nPACR and RACF each showed a significant inverse correlation with AACF in the anterior region [r = -0.57 (P < 0.01), r = -0.92 (P < 0.001)]. In the affected region of the patients with AP, (dS/SdP)ac was increased, but not significantly. Thus, LV global and regional diastolic functions were simultaneously impaired in patients with isolated left anterior descending artery disease.(ABSTRACT TRUNCATED AT 250 WORDS)

show abstract

Section: V Filling During Early Diastole In Angina Pectorismentioning

confidence: 99%

Regional diastolic function in effort angina pectoris: Assessment with biplane left ventriculography

et al. 1995

View full text Add to dashboard Cite

show abstract

The relation between left ventricular asynchrony, relaxation, outward wall motion and filling characteristics during control period and pacing-induced myocardial ischaemia in coronary artery disease

Takeuchi

Fujitani

Fukuzaki

1985

International Journal of Cardiology

View full text Add to dashboard Cite

Effects of left ventricular asynchrony on time constant and extrapolated pressure of left ventricular pressure decay in coronary artery disease

Takeuchi

Fujitani

Kurogane

et al. 1985

Journal of the American College of Cardiology

View full text Add to dashboard Cite

To elucidate the effects of ventricular asynchrony with or without myocardial ischemia on the time constant of left ventricular pressure decay and asymptote, that is, the level to which pressure would decrease if isovolumic pressure decrease continued infinitely, left ventriculography and pressure measurements were investigated in 14 normal subjects and 25 patients with coronary artery disease. Ventricular asynchrony was quantitated by the segmental area-time curve. This study consisted of two parts. 1) After a right atrial pacing stress test, the time constant and asymptote remained unchanged in eight normal subjects. In 18 patients with coronary artery disease and pacing-induced angina, asynchrony increased, the time constant was prolonged (64 +/- 13 to 94 +/- 17 ms, p less than 0.01) and the asymptote decreased (-22 +/- 10 to -46 +/- 20 mm Hg, p less than 0.01) after the pacing. 2) During right ventricular pacing at 80, 100 and 120 beats/min in the patients, asynchrony increased and the time constant was prolonged (55 +/- 7 versus 70 +/- 10, 47 +/- 11 versus 66 +/- 19, 36 +/- 7 versus 53 +/- 13 ms, respectively, p less than 0.01 versus right atrial pacing), whereas the asymptote was unchanged in six normal subjects compared with the value during right atrial pacing at each pacing rate. In seven patients with coronary artery disease, right ventricular pacing at 80, 100 and 120 beats/min also produced an increase in the time constant, while the asymptote was unchanged. Thus, prolongation of the time constant of left ventricular pressure decay may result from ventricular asynchrony even in the absence of myocardial ischemia.(ABSTRACT TRUNCATED AT 250 WORDS)

show abstract

Assessment of left ventricular function in ischemic heart disease The relation between pressure decay during the isovolumic relaxation phase and regional wall motion abnormality.

Cited by 7 publications

References 23 publications

Regional diastolic function in effort angina pectoris: Assessment with biplane left ventriculography

Regional diastolic function in effort angina pectoris: Assessment with biplane left ventriculography

The relation between left ventricular asynchrony, relaxation, outward wall motion and filling characteristics during control period and pacing-induced myocardial ischaemia in coronary artery disease

Effects of left ventricular asynchrony on time constant and extrapolated pressure of left ventricular pressure decay in coronary artery disease

Contact Info

Product

Resources

About