Assessment of left ventricular diastolic function by Doppler tissue imaging in children with end-stage renal disease

Abstract

DTI findings correlate well with conventional Doppler echocardiography findings. Children with ESRD show, after dialysis, echocardiographic signs of LV diastolic dysfunction.

Left ventricular systolic and diastolic function and carotid intima-media thickness in pediatric dialysis patients

“…Using this method, we showed that LV relaxation (E/A ratio) was impaired in dialyzed children as compared with controls. Besides a lot of adult studies, some pediatric studies also found a reduction in E/A ratio in children on dialysis [1,25,27,28]. Poor diastolic function in patients with ESRD was associated with anemia, hyperphosphatemia, increased CaxP ion product, and LVH [1,[25][26][27][28].…”

“…Over the last decade, abnormalities of the cardiac such as LVH and LV dysfunction, abnormalities of vascular such as arterial stiffness, increased cIMT, and coronary calcification have been accepted as early of markers of cardiomyopathy and atherosclerosis [6]. There are a few studies that showed these cardiovascular abnormalities in pediatric ESRD population [1,[5][6][7][8][17][18][19][20].…”

“…It is known that LV systolic function usually remains normal despite left ventricular hypertrophy in children with ESRD [1,25]. Studies in adults have shown that diastolic dysfunction may ultimately be at risk for LV systolic dysfunction and future congestive heart failure.…”

“…Cardiovascular structure and function abnormalities such as left ventricular hypertrophy (LVH), LV systolic and diastolic dysfunction, accelerated atherosclerosis, arrhythmias, and coronary artery calcification (CAC) contribute to high cardiovascular mortality in adults with ESRD [1][2][3]. Similar cardiovascular changes have also been observed in children and young adults on prolonged dialysis [4][5][6][7][8].…”

“…The aims of the present study were: (1) to evaluate left ventricular structure and function and carotid intima-media thickness (cIMT) and (2) to determine risk factors associated with these cardiovascular complications in pediatric patients with ESRD.…”