Assessment of left ventricular diastolic function: Comparison of Doppler echocardiography and gated blood pool scintigraphy

Friedman, Bruce J.; Drinković, Nikša; Miles, Helga; Shih, Wei-Jen; Mazzoleni, A; DeMaria, Anthony N.

doi:10.1016/s0735-1097(86)80307-2

Cited by 185 publications

(32 citation statements)

References 17 publications

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“…2) [11][12][13][14][15], The following mea surements were made on 5 cardiac cycles: (1) peak early diastolic flow velocity (E), measured as the height of the early diastolic peak of flow velocity; (2) peak late diastolic flow velocity (due to atrial con traction; A), measured as the height of the late dia stolic peak of flow velocity; (3) the ratio between early and late diastolic flow velocity (E/A); (4) the time taken for the peak early mitral flow velocity to decay by 50% (velocity half-time; VHT). This is not equivalent to 'pressure half-time' because in contrast with a stenotic atrioventricular valve, the decline in flow velocity across a normal valve is not exponen tial and during the phase of deceleration the pressure gradient is likely to be reversed [ 13].…”

Section: Echocardiographymentioning

confidence: 99%

“…Recent studies showed that M-mode and Doppler echocardiography were useful in evaluating left ventricular diastolic filling in dexes [9][10][11][12][13][14], and close correlation was dem onstrated with those measured from cine angiography [11] and radionuclide angiogra phy [12,15]. Abnormalities of left ventricu lar diastolic function were observed in left ventricular hypertrophy secondary to hyper tension or hypertrophic cardiomyopathy [9], ischemic heart disease [10], acute car diac allograft rejection [16], diabetic car diomyopathy [17] and doxorubicin cardiotoxicity [18].…”

Section: Introductionmentioning

confidence: 96%

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Doppler-Echo Evaluation of Left Ventricular Diastolic Filling in Patients with Mixed Connective Tissue Disease

Leung

Wong²,

Lau³

et al. 1990

Cardiology

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Left ventricular diastolic function was assessed in 17 patients (2 males and 15 females; mean age 44 ± 9 years) with mixed connective tissue disease (MCTD) and 18 sex-and age-matched healthy control subjects (2 males and 16 females; mean age 44 ± 8 years) by means of M-mode and pulsed Doppler echocardiography. None had clinical evidence of overt myocardial disease or abnormal left ventricular systolic function. Compared with the control group, patients with MCTD had a significantly longer isovolumic relaxation time (IVRT) (59 ± 7 versus 70 ± 12 ms; p < 0.01), a lower peak early diastolic flow velocity (E) (0.79 ± 0.10 versus 0.70 ± 0.07 m/s; p < 0.005), a higher peak late diastolic flow velocity due to atrial contraction (A) (0.47 ± 0.08 versus 0.54 ± 0.08 m/s; p < 0.05) and a reduced E/A ratio (1.72 ± 0.37 versus 1.33 ± 0.26; p < 0.005). Although there was no significant correlation of left ventricular diastolic filling indexes with age, heart rate, left ventricular end-diastolic and end-systolic dimensions, interventricular septal and left ventricular posterior wall thickness, and fractional shortening, the duration of illness was significantly related to IVRT (r = 0.62; p < 0.01), peak A (r = 0.79; p < 0.001) and velocity half-time (r = 0.54; p < 0.05). The results suggest the presence of an abnormal left ventricular diastolic filling pattern in patients with MCTD and may represent myocardial involvement in this disease.

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Section: Echocardiographymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

Doppler-Echo Evaluation of Left Ventricular Diastolic Filling in Patients with Mixed Connective Tissue Disease

Leung

Wong²,

Lau³

et al. 1990

Cardiology

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“…[7][8][9] Evaluation of early and late components of transmitral flow velocities has been shown to be a reliable means of identifying diastolic filling abnormalities. 10 This study was undertaken to evaluate left ventricular diastolic dysfunction in diabetic patients who had no clinical or electro cardio graphic evidence of cardiac disease.…”

Section: Diabetes and Heartmentioning

confidence: 99%

Evaluation of Left Ventricular Diastolic Dysfunction in Type Ii Diabetes Mellitus – The Role of Valsalva Maneuver

Uday¹,

Jayakumar²,

Jnaneshwari³

et al. 2014

jemds

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BACKGROUND & OBJECTIVES:Left ventricular diastolic dysfunction is known to occur in early stages of diabetic cardiomyopathy but its exact prevalence is not known. The present study was conducted to assess the prevalence of diastolic dysfunction in diabetic patients in the absence of hypertension or CAD. The role of valsalva maneuver in diagnosis of diastolic dysfunction was also studied. AIMS: To study left ventricular diastolic dysfunction in asymptomatic normotensive patients with Type 2 Diabetes. To study the role of valsalva maneuver in diagnosing diastolic dysfunction. METHODOLOGY: 100 consecutive asymptomatic normotensive patients (mean age 52.34 ±8.6 yrs.) with Type 2 diabetes free of any major clinical diabetic complications and having no evidence of CAD on non-invasive testing were studied for LV diastolic functions, using pulsed Doppler at the tip of mitral valve. The peak velocities of LV filling during the early rapid (E wave) and atrial contraction (A wave) phases, the ratio of the 2 filling velocities (E/A ratio) were recorded at end expiration at baseline and again during phase II of valsalva maneuver. RESULTS: LVDD was found in 54% of subjects of whom 11% had pseudo normal pattern of ventricular filling and 43% had impaired relaxation. LVDD was well correlated with age and duration of diabetes. CONCLUSION: LVDD is much more common in Type 2 diabetes who are free of clinically detectable heart disease. Pseudonormal pattern may account for a significant number of patients with diastolic dysfunction and failure to recognize it may lead to significant underestimation of the true prevalence of LVDD in these patients.

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“…9 -15 These relaxation disturbances can be assessed reliably by means of Doppler echocardiogra phic indexes of LV filling. 16 -24 In addition, Doppler-derived L V filling parameters correlate well with angiographicn and radionuclide 26 • 27 measurements. The objective of this study was to evaluate changes of L V diastolic function associated with acute cardiac allograft rejection using Doppler and M-mode echocardiography and to develop criteria for early noninvasive diagnosis of rejection.…”

mentioning

confidence: 89%

Noninvasive diagnosis of cardiac allograft rejection by means of pulsed Doppler and M-mode ultrasound.

Störk¹,

Möckel²,

Eichstädt³

et al. 1991

Journal of Ultrasound in Medicine

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The changes of left ventricular (L V) diastolic function associated with cardiac rejection were evaluated.Twenty-one cardiac allograft recipients aged 41 ± 9 years, 11 with moderate to severe and 10 allograft rejection without rejection at myocardial biopsy underwent serial echo examination, including peak velocity (PEV), pressure half~time (PHT), velodty~time integral (VTl-E) of early mitral flow, and isovolumetric relaxation period (IVRP). In transplant recipients, significantly higher values than in 22 age•matched healthy controls were found for PEV (71 versus 56 em fs; P < 0.01), PHT (51 versus 43 ms; P < 0.001), VTJ-E (72 versus 57 mm; P < 0.001), and IVRP (90 versus 73 ms; T he diagnosis of acute cardiac allograft rejection is still based on the results of endomyocardial biopsy.1 The introduction of cyclosporine in routine management of cardiac allograft recipients has markedly improved survival at the expense of loss of sensitivity of noninvasive markers of cardiac allograft rejection . u Recent studies report on a shortening of the isovolumetric relaxation period, 4 -7 a decrease in diastolic area change velocity of the left ventricle (LV).~ and a prolonged relaxation of the LV posterior wallR as possible markers of cardiac allograft rejection. These results indicate the important role of the relaxation Received November 26. 1990, from the •Department of Cardiol~ ogy and Intensive Care, University Hospital Rudolf Virchow; tGer man Heart Institute; and tlnstitute for Medical Statistics and Infor· matics, Free University, Berlin Germany. Revised manuscript accepted for publication April 10, 1991.Address correspondence and reprint requests to Dr. Stork: University Hospital Rudolf Virchow, Department of Cardiology and Intensive Care, Augustenburger Platz t , 1000 Berlin 65, Germany. P < 0.001). During rejection, heart rate increased significantly from 78 to 91 beats per minute (P < 0.01 ).Furthermore, a significant decrease was found for PEV from 73 to 63 cm/ s (P < 0.01), for PHT from 52 to 40 ms (P < 0.001), for VTI-E from 75 to 61 mm (P < 0.001), and for IVRP from 90 to 74 ms (P < 0.001) during cardiac rejection.Thus, sonographic evaluation of LV diastolic function helps to early detect cardiac rejection and to decrease the frequency of myocardial biopsy. KEY woRos: Heart transplantation, Left ventricular diastolic function, Echocardiography, Doppler ultrasound, Myocardial biopsy disturbances in early diastole in the pathophysiology of cardiac rejection . 9 -15 These relaxation disturbances can be assessed reliably by means of Doppler echocardiogra phic indexes of LV filling. 16 -24 In addition, Doppler-derived L V filling parameters correlate well with angiographicn and radionuclide 26 • 27 measurements. The objective of this study was to evaluate changes of L V diastolic function associated with acute cardiac allograft rejection using Doppler and M-mode echocardiography and to develop criteria for early noninvasive diagnosis of rejection. PATIENTS AND METHODS Study Patients and Study ProtocolThe over...

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Assessment of left ventricular diastolic function: Comparison of Doppler echocardiography and gated blood pool scintigraphy

Cited by 185 publications

References 17 publications

Doppler-Echo Evaluation of Left Ventricular Diastolic Filling in Patients with Mixed Connective Tissue Disease

Doppler-Echo Evaluation of Left Ventricular Diastolic Filling in Patients with Mixed Connective Tissue Disease

Evaluation of Left Ventricular Diastolic Dysfunction in Type Ii Diabetes Mellitus – The Role of Valsalva Maneuver

Noninvasive diagnosis of cardiac allograft rejection by means of pulsed Doppler and M-mode ultrasound.

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