Assessment of Left Atrial Function in Patients with Celiac Disease

Bayar, Nermin; Çekın, Ayhan Hilmi; Arslan, Şakir; Çağırcı, Göksel; Erkal, Zehra; Çay, Serkan; Köklü, Erkan; Küçükseymen, Selçuk

doi:10.1111/echo.12963

Cited by 11 publications

(18 citation statements)

References 37 publications

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“…Gastrointestinal diseases Celiac disease: Patients with celiac disease have significantly increased PWD and significantly higher interatrial, intra-left atrial, and intra-RA time than matched healthy controls [43].…”

Section: Normal Limit Values Of P-wave Dispersion (Pwd)mentioning

confidence: 99%

P-wave dispersion: an update

Pérez‐Riera

Abreu

Barbosa‐Barros

et al. 2016

Indian Pacing and Electrophysiology Journal

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P-wave dispersion (PWD, Pd or Pdis) is a noninvasive electrocardiographic (ECG) marker for atrial remodeling and predictor for atrial fibrillation (AF). PWD is defined as the difference between the widest and the narrowest P-wave duration recorded from the 12 ECG leads. Increased P-wave duration and PWD reflect prolongation of intraatrial and interatrial conduction time with lack of a well-coordinated conduction system within the atrial muscles, with inhomogeneous, asynchronic, pro-inflammatory and anti-inflammatory effect mediated by interleukin-6 (IL-6) in patients with the CG + GG genotype IL-6 -634C/G polymorphism [1] and discontinuous propagation of sinus impulses mainly between the left and right atria, interstitial/extracellular fibroblast activation and collagen deposition with fibrosis (via TGF-β) in atrial tissue, insufficient blood supply, significant not isotropic myoelectric activity, and thin wall thickness and consequent expansion tendency all well-known electrophysiological characteristics in patients with atrial arrhythmias and especially paroxysmal atrial fibrillation (PAF) [2].

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Section: Normal Limit Values Of P-wave Dispersion (Pwd)mentioning

confidence: 99%

P-wave dispersion: an update

Pérez‐Riera

Abreu

Barbosa‐Barros

et al. 2016

Indian Pacing and Electrophysiology Journal

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“…15 Left atrial total emptying fraction was reported to be an independent and strong predictor for the development of AF. 10 …”

Section: Discussionmentioning

confidence: 99%

“…The following LA emptying function parameters were calculated: LA passive emptying volume = Vmax-Vp, LA passive emptying fraction = (Vmax-Vp)/Vmax, LA active emptying volume = Vp-Vmin, LA active emptying fraction = (Vp-Vmin)/Vp. 10 All volumes were indexed to BSA and expressed in ml/m 2 . Atrial electromechanical coupling (PA) was defined as the time interval from the onset of the P wave on surface electrocardiogram to the beginning of the late diastolic wave (Am wave).…”

Section: Methodsmentioning

confidence: 99%

“…The difference between PA lateral and PA tricuspid was defined as inter-atrial electromechanical delay, the difference between PA lateral and PA septum was defined as left intra-atrial electromechanical delay, and the difference between PA septum and PA tricuspid was defined as right intra-atrial electromechanical delay. 10 …”

Section: Methodsmentioning

confidence: 99%

“…5,6 Atrial electromechanical delay had been shown to be prolonged in patients with nonrheumatic paroxysmal atrial fibrillation, obesity, hyperthyroidism, and celiac disease. 7-10 The pathophysiology and predictors of arrhythmias after treatment with AC are poorly defined. The hypothesis of the present study was that atrial mechanical and electromechanical features might be affected in patients treated with AC.…”

Section: Introductionmentioning

confidence: 99%

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Atrial Function in Patients with Breast Cancer After Treatment with Anthracyclines

Yaylali¹,

Saricopur²,

Yurtdaş³

et al. 2016

Arquivos Brasileiros De Cardiologia

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BackgroundAtrial electromechanical delay (EMD) is used to predict atrial fibrillation, measured by echocardiography.ObjectivesThe aim of this study was to assess atrial EMD and mechanical function after anthracycline-containing chemotherapy.MethodsFifty-three patients with breast cancer (48 ± 8 years old) who received 240 mg/m2of Adriamycin, 2400 mg/m2 of cyclophosphamide, and 960 mg/m2 of paclitaxel were included in this retrospective study, as were 42 healthy subjects (47 ± 9 years old). Echocardiographic measurements were performed 11 ± 7 months (median 9 months) after treatment with anthracyclines.ResultsLeft intra-atrial EMD (11.4 ± 6.0 vs. 8.1 ± 4.9, p=0.008) and inter-atrial EMD (19.7 ± 7.4 vs. 14.7 ± 6.5, p=0.001) were prolonged; LA passive emptying volume and fraction were decreased (p=0.0001 and p=0.0001); LA active emptying volume and fraction were increased (p=0.0001 and p=0.0001); Mitral A velocity (0.8 ± 0.2 vs. 0.6 ± 0.2, p=0.0001) and mitral E-wave deceleration time (201.2 ± 35.6 vs. 163.7 ± 21.8, p=0.0001) were increased; Mitral E/A ratio (1.0 ± 0.3 vs. 1.3 ± 0.3, p=0.0001) and mitral Em (0.09 ± 0.03 vs. 0.11 ± 0.03, p=0.001) were decreased; Mitral Am (0.11 ± 0.02 vs. 0.09 ± 0.02, p=0.0001) and mitral E/Em ratio (8.8 ± 3.2 vs. 7.6 ± 2.6, p=0.017) were increased in the patients.ConclusionsIn patients with breast cancer after anthracycline therapy: Left intra-atrial, inter-atrial electromechanical intervals were prolonged. Diastolic function was impaired. Impaired left ventricular relaxation and left atrial electrical conduction could be contributing to the development of atrial arrhythmias.

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Atrial fibrillation and gastroesophageal reflux disease: the cardiogastric interaction

Linz

Hohl

Vollmar³

et al. 2016

Europace

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Atrial fibrillation (AF) is the most common sustained arrhythmia and is associated with significant morbidity and mortality. Multiple conditions like hypertension, heart failure, diabetes, sleep apnoea, and obesity play a role for the initiation and perpetuation of AF. Recently, a potential association between gastroesophageal reflux disease (GERD) and AF development has been proposed due to the close anatomic vicinity of the oesophagus and the left atrium. As an understanding of the association between acid reflux disease and AF may be important in the global multimodal treatment strategy to further improve outcomes in a subset of patients with AF, we discuss potential atrial arrhythmogenic mechanisms in patients with GERD, such as gastric and subsequent systemic inflammation, impaired autonomic stimulation, mechanical irritation due to anatomical proximity of the left atrium and the oesophagus, as well as common comorbidities like obesity and sleep-disordered breathing. Data on GERD and oesophageal lesions after AF-ablation procedures will be reviewed. Treatment of GERD to avoid AF or to reduce AF burden might represent a future treatment perspective but needs to be scrutinized in prospective trials.

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Assessment of Left Atrial Function in Patients with Celiac Disease

Abstract: Although atrial mechanical functions are preserved in patients with CD, a slower electrical conduction was found, suggesting an increased risk of AF in this group of patients.

Cited by 11 publications

References 37 publications

P-wave dispersion: an update

P-wave dispersion: an update

Atrial Function in Patients with Breast Cancer After Treatment with Anthracyclines

Atrial fibrillation and gastroesophageal reflux disease: the cardiogastric interaction

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