Assessment of knowledge, attitude, and practice in relation to use of isotretinoin among Al-Madinah population, Saudi Arabia

Molla, A Layes; Alrizqi, Hassan Abdullah; Alruhaili, Emtinan Mohammed Salem; Alrizqi, Saad Abdullah; Alsubhi, Arwa Musaad

doi:10.24911/ijmdc.51-1571752077

Cited by 9 publications

(18 citation statements)

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“…The possession of a prescription for isotretinoin was expected, knowing that a prescription and consent is needed in order for a pharmacy to dispense it. This study is also within the range of two previous studies [ 10 , 11 ].…”

Section: Discussionsupporting

confidence: 89%

“…This cross-sectional, descriptive study was reviewed by the scientific board, and ethical approval was obtained from King Abdulaziz University Hospital, Jeddah, Saudi Arabia. A total of 1257 responses were collected, using an electronic validated Arabic questionnaire taken with permission from the authors of a previous similar study [ 11 ]. To increase our sample size, the questionnaire was disseminated through social media (Whats-App and Twitter).…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Females' Knowledge and Use of Isotretinoin (Roaccutane) in the Western Region of Saudi Arabia

Bakheet¹,

Alghanemi²,

Alsiyoufi³

et al. 2020

Cureus

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Section: Discussionsupporting

confidence: 89%

Section: Methodsmentioning

confidence: 99%

Females' Knowledge and Use of Isotretinoin (Roaccutane) in the Western Region of Saudi Arabia

Bakheet¹,

Alghanemi²,

Alsiyoufi³

et al. 2020

Cureus

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“…is study aims to investigate the awareness of women of childbearing age in the province of Makkah, Saudi Arabia, regarding the teratogenicity of isotretinoin and patients' compliance with the precautionary measures associated with the medication. ere have been similar studies conducted in different regions of Saudi Arabia including Western region, Al-Madinah, Riyadh, Qassim, and Al Ahsa, albeit focusing on the general understanding of isotretinoin usage and the concomitant compliance [5,12,[15][16][17]. However, this study delved deeper on the teratogenic aspect of isotretinoin and its relation to pregnancy, highlighting the importance of safety of the childbearing woman and the fetus.…”

Section: Discussionmentioning

confidence: 74%

“…e vast majority (91%) of study participants claimed understanding and awareness on the side effects associated with isotretinoin use, which is consistent with previous studies. Molla et al (2020) reported that 62 of their respondents are generally aware of the side effects, while Al-Harbi (2010) noted that 77% of their study participants are knowledgeable about the medication and its uses [15,16]. Another study conducted on Saudi women in Western Saudi Arabia revealed that around 85% of their sample population is aware of the side effects of the medication [21].…”

Section: Women's Practice and Awarenessmentioning

confidence: 99%

Awareness on Teratogenic Effects of Isotretinoin and Compliance with Precautionary Measures among Women of Childbearing Age in Makkah Province, Saudi Arabia

Al-Mekhlafi¹,

Attiyah²,

Haddad³

et al. 2021

Obstetrics and Gynecology International

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Acne vulgaris ranks among the most common dermatologic conditions encountered during adolescence up to adulthood. For moderate to severe cases of acne, isotretinoin is indicated as it is considered the most efficacious medication against acne. However, isotretinoin use is known to have its side effects and most importantly is the drug’s teratogenic potential. As a response, programs such as the Retinoid Pregnancy Prevention Program (PPP), System to Manage Accutane-Related Teratogenicity (SMART), and iPLEDGE were put into action as attempts to promote awareness on isotretinoin’s teratogenicity and reduce the incidence of exposed pregnancies. Such programs are lacking in Saudi Arabia. This study aimed, therefore, to evaluate the awareness of women of childbearing age in Makkah Province, Saudi Arabia, with regards to the side effects of the medication, specifically its teratogenicity. This study also intended to assess the compliance of both doctors and patients with the recommendations and precautions associated with isotretinoin. A cross-sectional study was conducted on 766 women participants using a previously validated questionnaire. Results showed that majority of the respondents (91%) are generally aware of the side effects of isotretinoin use, particularly its teratogenicity. However, lapses have been identified with regards to the compliance of both the treating physician and the patient. Three-fourths of sexually active women did not use any form of contraception while being on isotretinoin treatment. Two-thirds of the study participants responded that they were not issued approval forms indicating their understanding of the side effects of isotretinoin and the importance of compliance to the treating physician’s instructions; 11.5% claimed that their doctors did not perform any blood tests; and 67.7% claimed that no pregnancy test was performed at any time during the treatment. These findings strongly suggest a need for improvement when it comes to compliance of both doctors and patients. It is recommended that doctor-patient communication be more comprehensive and more efforts should be made to follow international guidelines in that regard.

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“…Moreover, Previous studies showed that the use of Isotretinoin is associated with many side effects; the most observed and identified side effect was mucocutaneous such as retinoid dermatitis, severe retinoid cheilitis, epistaxis, dry eyes, or conjunctivitis, which are dose-dependent predictable side effects. Among adolescents, mood changes, including depression, are commonly reported; other psychiatric manifestations such as anxiety and suicidal thoughts are still controversial [11][12][13]. Teratogenicity is well known and regarded as one of the most severe and devastating adverse effects.…”

Section: Introductionmentioning

confidence: 99%

The Prevalence of using Prescribed & Unprescribed “Roaccutane (Isotretinoin)” among Females Riyadh, Saudi Arabia: A Cross Sectional Study

Mahmoud

Almohaini

Assiri

et al. 2021

JPRI

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Aims: To determine the prevalence of using prescribed and unprescribed Isotretinoin and to assess knowledge of its adverse effects among females in Riyadh, SA. Study design: cross-sectional study. Place and Duration of Study: online questionnaire collected throughout two months by distributing the questionnaire via. social media platforms. Methodology: We included 385 female patients (age range 15-45 years) use Roaccutane (Isotretinoin) with or without prescribed. Statistical analysis was performed using Rv 3.6.3. Counts and percentages was used to summarize the distribution of categorical variables and data. Chi-square test was used to estimate the association between categorical variables. Hypothesis testing was performed at a 5% level of significance. Results: 568 respondents completed the questionnaire. Of these, 440 were from Riyadh. The majority of respondents were aged 15 – 20 (46.4%) and 21 – 25 (35.2%). Knowledge regarding some side effects of Roaccutane was significantly higher in respondents who reported using Roaccutane than those who did not. Knowledge of dry and cracked lips as a side effect was significantly higher in users (91.9%) than non-users (73.1%). Similarly, knowledge regarding dry eyes, depression, continuous thirst, nose dryness, bleeds, and effect of Roaccutane on liver biochemical profile, lipid profile, and bones was higher in users than non-users, regarding the teratogenic effect of Roaccutane was insignificantly different between groups. Conclusion: Females in Riyadh are aware of the side effects of isotretinoin, particularly dryness of the skin, eyes, and lips. Yet there is insufficient knowledge regarding its teratogenic effect. Based on the reported results, a few participants obtained Roaccutane without a prescription from the doctor, and some obtained their information from unreliable sources (i.e., friends/relatives). Our results suggest good practice towards the prescription of isotretinoin.

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Assessment of knowledge, attitude, and practice in relation to use of isotretinoin among Al-Madinah population, Saudi Arabia

Cited by 9 publications

References 0 publications

Females' Knowledge and Use of Isotretinoin (Roaccutane) in the Western Region of Saudi Arabia

Females' Knowledge and Use of Isotretinoin (Roaccutane) in the Western Region of Saudi Arabia

Awareness on Teratogenic Effects of Isotretinoin and Compliance with Precautionary Measures among Women of Childbearing Age in Makkah Province, Saudi Arabia

The Prevalence of using Prescribed & Unprescribed “Roaccutane (Isotretinoin)” among Females Riyadh, Saudi Arabia: A Cross Sectional Study

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