Assessment of kidney function in chronic kidney disease by combining diffusion tensor imaging and total kidney volume

Li, Xuesong; Zhang, Qingjuan; Zhu, Jiang; Zhou, Qingqing; Yu, Yu-Sheng; Hu, Zhang-Chun; Xia, Zi-Yi; Liang, Wei; Yin, Xindao; Zhang, Hong

doi:10.1007/s11255-021-02886-8

Cited by 11 publications

(2 citation statements)

References 25 publications

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“…The ADC reflects the diffusion of water molecules in the renal cortex and medulla. This has diagnostic value for evaluating chronic kidney disease as the ADC and FA value decrease when kidney disease occurs [ 6 – 8 ]. Our study showed the ADC and FA for both the cortex and medulla declined in the group with LN, compared with the control group, with the largest decline in the type IV group.…”

Section: Discussionmentioning

confidence: 99%

Clinical study on the use of advanced magnetic resonance imaging in lupus nephritis

Chen

Zhou

et al. 2022

BMC Med Imaging

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Objectives To investigate the correlation between the histopathology of the kidney and clinical indicators in patients with lupus nephritis (LN) using magnetic resonance imaging (MRI). Methods A total 50 female participants were enrolled in the study. Thirty patients with LN were divided into types 2, 3, 4, and 5, according to their pathological features. The control group consisted of 20 healthy female volunteers. Serum creatinine, C3, C1q, and anti-ds-DNA were measured. Conventional MRI, DTI, DWI, and BOLD scanning was performed to obtain the FA, ADC, and R2* values for the kidney. Results Compared with the control group, FA and the ADC were decreased in patients with LN, while the R2* value was increased (P < 0.05). The overall comparison of the SLEDAI (Activity index of systemic lupus erythematosus) score, total pathological score, AI, and serum creatinine C3 showed that these were significantly different between the two groups (P < 0.05). FA and the ADC were negatively correlated with urinary, blood ds-DNA, and serum creatinine and positively correlated with C1q (P < 0.05). The R2* value was positively correlated with urinary NGAL, blood ds-DNA, and serum creatinine (P < 0.05). FA and the ADC were negatively correlated with the SLEDAI score, total pathological score, AI, CI, nephridial tissue C3, and C1q. The R2* value was positively correlated with the SLEDAI score, total pathological score, AI, CI, nephridial tissue C3, and C1q (P < 0.05). Conclusions MRI examination in female patients with LN was correlated with pathologic test results, which may have clinical significance in determining the disease’s severity, treatment, and outcome.

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Section: Discussionmentioning

confidence: 99%

Clinical study on the use of advanced magnetic resonance imaging in lupus nephritis

Chen

Zhou

et al. 2022

BMC Med Imaging

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“…However, in recent years, research by Moustakim et al [ 28 ] found that some CKD patients often had an atypical history of RTI before onset or were prone to RTI during treatment. Upper RTI can be directly infected by bacteria or caused by a variety of viruses, and these bacteria and viruses also have a certain impact on the kidney, which may lead to kidney disease [ 29 ]. On the one hand, bacteria and viruses can invade kidney organization directly; on the other hand, bacteria and viruses can serve as antigens and cause immune complex sex nephritis.…”

Section: Discussionmentioning

confidence: 99%

Relationship between Acute Respiratory Tract Infection and the Serum 25(OH) D3 Level in Chronic Kidney Disease Patients and Its Prevention and Treatment

Cai

Wang

Zhong

et al. 2022

BioMed Research International

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Observational studies and randomized controlled studies propose that vitamin D plays a significant role in preventing acute respiratory tract infection (RTI); however, results are inconsistent and the optimal serum 25-hydroxyvitamin D (25-OH-D3) concentration remains unknown. This study explores the risk factors associated with acute RTI in patients with chronic kidney disease (CKD) and analyzes its correlation with serum 25-OH-D3 levels, to provide appropriate preventive treatment measures for CKD patients complicated with acute RTI. Seventy cases of CKD patients treated in the department of nephrology of Jiangxi Provincial People’s Hospital are recruited as the research objects and divided into a control group (CKD without RTI) and an observation group (CKD with RTI), with 35 cases in each group. The laboratory indexes and serum 25-OH-D3 levels are compared between the two groups. The area under the receiver operating characteristic curve (ROC) of 25-OH-D3 in the diagnosis of CKD patients complicated with RTI is 0.892, and the standard error is 0.038. The glomerular filtration rates (GFR) are 48.32 ± 9.87 mL / min and 50.18 ± 20.71 mL / min in the control group and the experimental group, respectively, with no statistical significance between the two groups ( P > 0.05 ). The serum 25-OH-D3 content in the control group ( 35.08 ± 6.2 nmol / L ) is dramatically higher than that in the observation group ( 20.71 ± 5.87 nmol / L ) ( P < 0.05 ). The proportion of patients with diabetes mellitus (DM) in the control group and observation group is 25.71% and 68.57%, respectively, with a considerable difference ( P < 0.05 ). In the control group and the experimental group, the proportion of patients with oral vitamin D receptor agonists is 54.29% and 11.43%, respectively, and the difference is significant ( P < 0.05 ). Results show that the serum 25-OH-D3 level is highly correlated with the occurrence of RTI in CKD patients. In addition, it is related to patients’ age, DM, and vitamin D receptor agonists.

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Quantitative MRI of the Kidneys: Rationale and Challenges

Francis

2023

Advanced Clinical MRI of the Kidney

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Assessment of kidney function in chronic kidney disease by combining diffusion tensor imaging and total kidney volume

Cited by 11 publications

References 25 publications

Clinical study on the use of advanced magnetic resonance imaging in lupus nephritis

Clinical study on the use of advanced magnetic resonance imaging in lupus nephritis

Relationship between Acute Respiratory Tract Infection and the Serum 25(OH) D3 Level in Chronic Kidney Disease Patients and Its Prevention and Treatment

Quantitative MRI of the Kidneys: Rationale and Challenges

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