Assessment of intraoperative frozen sections diagnosed based on remote reporting by telepathology

Elhassan, Muwada E.; Anikin, Vladimir; Emma, Beddow; McGonigle, Niall; Kyparissopoulos, Dimitrios; Rice, Alexandra; Montero, Ángeles; Yancheva, Slaveya; Bell, Alex; Shah, Pratibha Jain; Ross, Stephanie; Velani, Asha; Ahmed, I Shoukry; Croud, James; Nicholson, Andrew G.

doi:10.1097/01.pat.0000454315.92803.72

Cited by 1 publication

(3 citation statements)

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“…Similar high levels of concordance between dynamic/WSI telepathology and in-house conventional microscopy in frozen section diagnosis have also been reported. [1245121524]…”

Section: Discussionmentioning

confidence: 99%

“…Published turnaround time for the frozen section by telepathology varies[9101415192226] and depends mainly on the specimens interpreted, devices used, and pathologists’ experience in frozen section diagnosis and using digital images.…”

Section: Discussionmentioning

confidence: 99%

“…Each scanner included a motorized microscope with a set of objective lenses. Although WSI had been successfully demonstrated for frozen section interpretation by others,[49101112131415] we adopted their live-view mode instead of WSI during the study. WSI requires slide scanning and transfer of large files, which were more time-consuming in these two low-volume telepathology systems in addition to the challenge of internet congestion in the area where the study was conducted (4G connection was used).…”

Section: Methodsmentioning

confidence: 99%

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Parathyroid Frozen Section Interpretation via Desktop Telepathology Systems: A Validation Study

Chandraratnam¹,

Santos

Chou

et al. 2018

Journal of Pathology Informatics

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Background:Telepathology can potentially be utilized as an alternative to having on-site pathology services for rural and regional hospitals. The goal of the study was to validate two small-footprint desktop telepathology systems for remote parathyroid frozen sections.Subjects and Methods:Three pathologists retrospectively diagnosed 76 parathyroidectomy frozen sections of 52 patients from three pathology services in Australia using the “live-view mode” of MikroScan D2 and Aperio LV1 and in-house direct microscopy. The final paraffin section diagnosis served as the “gold standard” for accuracy evaluation. Concordance rates of the telepathology systems with direct microscopy, inter-pathologist and intra-pathologist agreement, and the time taken to report each slide were analyzed.Results:Both telepathology systems showed high diagnostic accuracy (>99%) and high concordance (>99%) with direct microscopy. High inter-pathologist agreement for telepathology systems was demonstrated by overall kappa values of 0.92 for Aperio LV1 and 0.85 for MikroScan D2. High kappa values (from 0.85 to 1) for intra-pathologist agreement within the three systems were also observed. The time taken per slide by Aperio LV1 and MicroScan D2 within three pathologists was about 3.0 times (P < 0.001, 95% confidence interval [CI]: 2.8–3.2) and 7.7 times (P < 0.001, 95% CI: 7.1–8.3) as long as direct microscopy, respectively, while MikroScan D2 took about 2.6 times as long as Aperio LV1 (P < 0.001, 95% CI: 2.4–2.7). All pathologists evaluated Aperio LV1 as being more user-friendly.Conclusions:Telepathology diagnosis of parathyroidectomy frozen sections through small-footprint desktop systems is accurate, reliable, and comparable with in-house direct microscopy. Telepathology systems take longer than direct microscopy; however, the time taken is within clinically acceptable limits. Aperio LV1 takes shorter time than MikroScan D2 and is more user-friendly.

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“…Similar high levels of concordance between dynamic/WSI telepathology and in-house conventional microscopy in frozen section diagnosis have also been reported. [1245121524]…”

Section: Discussionmentioning

confidence: 99%