Assessment of Insulin Producing Function of the Pancreas and the Marker of Insulin Resistance in Low-Progressive Autoimmune Diabetes in Adults (Lada) Patients

Abstract

It were examined 262 patients, among which there were 121 patients with low-progressive autoimmune diabetes of adults (LADA), 60 patients with type 1 diabetes mellitus (DM) and 81 patients with diagnosed type 2 DM. It was performed comparative analysis of C-peptide level and indicators of insulin resistance (IR) in patients in the monitoring groups. It was installed the authentic reduction of C-peptide level in the blood of LADA patients and type 1 DM patients compared with type 2 DM patients. It wasn’t established in the absence of significant differences on this index between LADA patients and type 1 DM patients, despite on a significant reduction in C-peptide in patients LADA compared with controls, significant differences in this case. According to the results of calculating several coefficients, that are recommended for the determination of IR, it was confirmed the presence of this state in patients LADA. At the same time indicators of IR in LADA patients were significantly lower than in type 2 DM patients. These data indicate that the disorders of carbohydrate metabolism in LADA patients are caused by the decrease in the insulin secretion in pancreas β-cells, and also by the presence of IR.