Authors' contribution: EPSL, DMFS, CEA, SMSIF were responsible for the design and planning of the experiments. DMFS, VPSM, FBS, performed the experimentais procedures. JSC, LCS, CEA, DMFS, FBS, EPSL were responsible for the analysis and/or interpretation of the data. EPSL, CEA, MTAG-Z, contributed reagents and materials necessary for the study. DMFS, FBS, JSC, LCS and EPSL were responsible for writing the manuscript.