Assessment of Inflammatory Markers in Preeclampsia

Bansal, Prerna; Shaker, Ivvala Anand; Bansal, Anupam; Kaushik, G.G.

doi:10.5005/jp-journals-10054-0071

Cited by 6 publications

(4 citation statements)

References 21 publications

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“…The average levels of weight, average levels of systolic and diastolic blood pressure levels were significantly higher among preeclamptic group compared to the normal pregnancy group. (Table 2) These results are comparable with the studies conducted elsewhere [11][12][13] . Patho-physiologically, the hallmark of preeclampsia includes increased vasoconstriction resulting in maternal hypertension and reduced uteroplacental blood flow, disturbed vascular endothelial integrity with increased vascular permeability, and activation of the coagulation cascade [5,7,13,14] .…”

Section: Discussionsupporting

confidence: 89%

Association of lipoprotein (a) and high-sensitive C-reactive protein in preeclampsia

Savadi¹,

Anandpara²,

Rashmi³

2021

Int. J. Adv. Biochem. Res.

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Background: Preeclampsia is a hypertensive disorder associated with substantial perinatal morbidity and mortality. Neonates born to hypertensive mothers are at increased risk of prematurity and foetal growth restriction. Timely prediction and accurate diagnosis is the key to limiting the morbidity and mortality caused by preeclampsia. Early identification of PE using inflammatory biomarkers could reduce PE related comorbidities. Aim: To compare levels inflammatory markers: hsCRP and Lipoprotein(a) levels in preeclamptic pregnant women, with the levels of inflammatory markers among women with normal pregnancy at a tertiary care teaching hospital Material and Methods: This comparative cross-sectional study included 60 Preeclamptic women and 60 apparently healthy singleton pregnant women matched for gestational age and parity. Data was analyzed in SPSS V:16. To find association between inflammatory markers and blood pressure levels, statistical tests like chi-square, independent student t-test were applied. Results: Lp(a) and hsCRP levels were significantly higher among preeclamptic group compared to normal pregnancy group and these levels had moderate positive correlation with SBP (r=0.650) and DBP (0.627) among preeclamptic women. Conclusion: Increased levels of lipoprotein (a) and hsCRP are found in the present study, which are correlating with the progression of preeclampsia by causing endothelial dysfunction and inflammatory cascade. Also, earliest detection of Lp(a) and hsCRP in pregnancy could help to detect preeclampsia and to prevent its further complications.

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Section: Discussionsupporting

confidence: 89%

Association of lipoprotein (a) and high-sensitive C-reactive protein in preeclampsia

Savadi¹,

Anandpara²,

Rashmi³

2021

Int. J. Adv. Biochem. Res.

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“…In contrast, other studies report no significant changes in CRP levels between normotensive and pre‐eclamptic women 20,22 . Reports also indicate elevated hs‐CRP level in severe PE cases as compared to mild cases 31,34–36,10 . Majority of the studies indicate that hs‐CRP could be used as a marker for the detection of PE and suggest that hs‐CRP may be utilized as a significant indicator of severity of PE at third‐trimester pregnancy (30–39 weeks) 16,17,29,37 .…”

Section: Discussionmentioning

confidence: 99%

“…30 High serum CRP levels in PE cases during second and third trimester of pregnancy have been reported earlier. 15,16,[31][32][33][34] In contrast, other studies report no significant changes in CRP levels between normotensive and pre-eclamptic women. 20,22 Reports also indicate elevated hs-CRP level in severe PE cases as compared to mild cases.…”

Section: Discussionmentioning

confidence: 99%

“…20,22 Reports also indicate elevated hs-CRP level in severe PE cases as compared to mild cases. 31,[34][35][36]10 Majority of the studies indicate that hs-CRP could be used as a marker for the detection of PE and suggest that hs-CRP may be utilized as a significant indicator of severity of PE at third-trimester pregnancy (30-39 weeks). 16,17,29,37 However, these findings were observed when PE was already developed making it challenging to understand whether systemic inflammation precedes and predicts the development of PE.…”

Section: Discussionmentioning

confidence: 99%

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Longitudinal profile of high‐sensitivity C‐reactive protein in women with pre‐eclampsia

Dangat

Wadhwani

Randhir

et al. 2023

American J Rep Immunol

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Problem: C-reactive protein (CRP) is a marker for inflammation and its role as a possible biomarker for an early prediction of pre-eclampsia (PE) is unclear. The present study investigates the levels of high-sensitivity CRP (hs-CRP) longitudinally across pregnancy in women with PE and compares them to women without PE (non-PE). Method of Study: A total of 324 pregnant women [216 non-PE and 108 PE women]were included in this study. Maternal blood was taken at four different intervals (V1 = 11-14 weeks, V2 = 18-22 weeks, V3 = 26-28 weeks, and V4 = at delivery).Results: Maternal serum hs-CRP levels were higher at V1, V2, and V3 (p < .05 for all) in the PE group compared to the non-PE group. The hs-CRP levels were associated with maternal blood pressure throughout pregnancy. Maternal hs-CRP levels did not differ among early and late onset PE. Higher maternal hs-CRP levels were associated with the increased risk of PE in unadjusted model in early pregnancy. However, there was no significance after adjusting for confounding factors. Conclusions:Our findings suggest although the levels of hs-CRP were higher in PE in early pregnancy, they are not associated with an increased risk of PE.

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Inflammatory markers and their association with preeclampsia among pregnant women: A systematic review and meta-analysis

Puttaiah,

Kirthan,

Sadanandan

et al. 2024

Clinical Biochemistry

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Assessment of Inflammatory Markers in Preeclampsia

Cited by 6 publications

References 21 publications

Association of lipoprotein (a) and high-sensitive C-reactive protein in preeclampsia

Association of lipoprotein (a) and high-sensitive C-reactive protein in preeclampsia

Longitudinal profile of high‐sensitivity C‐reactive protein in women with pre‐eclampsia

Inflammatory markers and their association with preeclampsia among pregnant women: A systematic review and meta-analysis

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