Assessment of inflammatory markers as predictor of outcome in COVID-19 patients on noninvasive ventilator in ICU setup

Abstract

According to the existing evidence, inflammatory reactions appear to have a significant impact on the emergence of COVID-19. This study aims to determine the severity of COVID-19-associated laboratory measures, particularly in patients receiving non-invasive ventilation. METHOD: This observational study involved 150 patients who were on non-invasive ventilation and tested positive for the Covid19 RTPCR/GENEXPERT gene. C reactive protein, D dimer, and ferritin examinations were frequently collected and Data were entered. Microsoft Excel, and SPSS software version 17.0 was used for the statistical analysis. The components of descriptive statistics are mean, standard deviation, frequency, and percentage. Student T-test was used to evaluate CRP, D Dimer, and ferritin between covid positive patients' outcome variables P<0.05 significant analysis will be done using SPSS software version 25. Result: CRP levels were above 10; 131 patients with bad outcomes (59) and 73 patients (55.7) survived. Thirty-five patients (39%) and 55 patients (61%) with D-dimer values of 1 survived. 64 Patients (50.8%) with ferritin levels of more than 300 survived, while 62 Patients (48%) died. Conclusion: In our study population, elevated ferritin and D-dimer levels were found to be related to bad outcomes, whereas elevated CRP levels did not.