Assessment of Inflammatory Hematological Ratios (NLR, PLR, MLR, LMR and Monocyte/HDL–Cholesterol Ratio) in Acute Myocardial Infarction and Particularities in Young Patients

Tudurachi, Bogdan-Sorin; Anghel, Larisa; Tudurachi, Andreea; Sascău, Radu Andy; Stătescu, Cristian

doi:10.3390/ijms241814378

Cited by 29 publications

(14 citation statements)

References 79 publications

(149 reference statements)

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“…MLR and PLR are currently considered hematological markers for indicating inflammation in diseases [ 22 ]. Demirbaş et al investigated the role of MLR and PLR in vitiligo and found that it was statistically significantly higher in vitiligo patients as compared to the control group.…”

Section: Discussionmentioning

confidence: 99%

An Evaluation of the Hematological Markers of Systemic Inflammation and Oxidative Stress in Vitiligo: A Case-Control Study

Temel,

Orenay,

Karaosmanoglu

2024

Cureus

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Introduction Melanocyte dysfunction in vitiligo is considered to be due to genetics, inflammation, and autoimmunity. Research has shown that oxidative stress plays a significant role in triggering these conditions. Currently, there are several markers indicating hematological inflammation and oxidative stress. This study aimed to investigate the status of inflammation and oxidative stress markers in vitiligo. Methods This study included patients with vitiligo and age-gender-matched healthy controls. C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-high-density lipoprotein ratio (MHR) and extent of vitiligo were calculated and compared. Results The study included 138 participants (69 vitiligo and 69 controls). The mean was 41.46 years with a female predominance (55.1%). The patient group demonstrated higher levels of platelets, neutrophils, CRP, NLR, MLR, PLR, and HDL and lower levels of lymphocytes and HDL compared to the control group (p>0,05). The only significantly different value between the groups was MHR (p=0.03). The generalized vitiligo group demonstrated higher levels of platelets, neutrophils, monocytes, CRP, NLR, PLR, and MLR, and lower levels of lymphocytes and HDL compared to the localized group. The only significantly different values between the groups were MHR and MLR (p=0.02, p=0.03). Conclusion This study found that MHR and CRP values were higher in vitiligo patients. Additionally, MHR and MLR values were higher in patients with generalized vitiligo. These results suggest that MHR is a reliable indicator marker for systemic inflammation and oxidative stress in vitiligo.

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Section: Discussionmentioning

confidence: 99%

An Evaluation of the Hematological Markers of Systemic Inflammation and Oxidative Stress in Vitiligo: A Case-Control Study

Temel,

Orenay,

Karaosmanoglu

2024

Cureus

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“…Neutrophil and lymphocyte counts were determined by conducting a complete blood count on blood specimens using a Beckman Coulter automated blood analyzer in an MEC, expressed as × 10 3 cells/µL. NLR was calculated as the absolute neutrophil count divided by the absolute lymphocyte count [ 23 ].…”

Section: Methodsmentioning

confidence: 99%

The neutrophil-to-lymphocyte ratio is associated with all-cause and cardiovascular mortality among individuals with hypertension

Zhang,

Wei,

Wang

et al. 2024

Cardiovasc Diabetol

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Background Identifying reliable prognostic markers is crucial for the effective management of hypertension. The neutrophil-to-lymphocyte ratio (NLR) has emerged as a potential inflammatory marker linked to cardiovascular outcomes. This study aims to investigate the association of NLR with all-cause and cardiovascular mortality among patients with hypertension. Methods This study analyzed data from 3067 hypertensive adults in the National Health and Nutritional Examination Surveys (NHANES) from 2009 to 2014. Mortality details were obtained from the National Death Index (NDI). Restricted cubic spline (RCS) was deployed to visualize the association of the NLR with mortality risk. Weighted Cox proportional hazards models were employed to assess the independent association of NLR with mortality risk. Time-dependent receiver operating characteristic curve (ROC) analysis was conducted to access the predictive ability of NLR for survival. Mediation analysis was used to explore the indirect impact of NLR on mortality mediated through eGFR. Results Over a median 92.0-months follow-up, 538 deaths occurred, including 114 cardiovascular deaths. RCS analysis revealed a positive association between NLR and both all-cause and cardiovascular mortality. Participants were stratified into higher (> 3.5) and lower (≤ 3.5) NLR groups. Weighted Cox proportional hazards models demonstrated that individuals with higher NLR had a significantly increased risk of all-cause (HR 1.96, 95% confidence interval (CI) 1.52–2.52, p < 0.0001) and cardiovascular mortality (HR 2.33, 95% CI 1.54–3.51, p < 0.0001). Stratified and interaction analysis confirmed the stability of the core results. Notably, eGFR partially mediated the association between NLR and both all-cause and cardiovascular mortality by a 5.4% and 4.7% proportion, respectively. Additionally, the areas under the curve (AUC) of the 3-, 5- and 10- year survival was 0.68, 0.65 and 0.64 for all-cause mortality and 0.68, 0.70 and 0.69 for cardiovascular mortality, respectively. Conclusion Elevated NLR independently confers an increased risk for both all-cause and cardiovascular mortality in individuals with hypertension.

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“…49,50 Consequently, the PLR is commonly used in clinical examinations as an indicator of both the state and degree of the inflammation. 51 Besides, previous animal study has suggested that a HFD can lead to reduction in intestinal granulocytes, related with an elevation in gut permeability and inflammation. 52 In our study, LAX significantly reduced the high platelet counts, PLR and also markedly normalized the lymphocytes and granulocytes counts, consistent with its anti-inflammatory properties.…”

Section: Contentsmentioning

confidence: 99%

Lactobacillus casei‐fermented Amomum xanthioides ameliorates metabolic dysfunction in high‐fat diet‐induced obese mice

Wang,

Hwang,

Choi

et al. 2024

The FASEB Journal

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Amomum xanthioides (AX) has been used as an edible herbal medicine to treat digestive system disorders in Asia. Additionally, Lactobacillus casei is a well‐known probiotic commonly used in fermentation processes as a starter. The current study aimed to investigate the potential of Lactobacillus casei‐fermented Amomum xanthioides (LAX) in alleviating metabolic disorders induced by high‐fat diet (HFD) in a mouse model. LAX significantly reduced the body and fat weight, outperforming AX, yet without suppressing appetite. LAX also markedly ameliorated excessive lipid accumulation and reduced inflammatory cytokine (IL‐6) levels in serum superior to AX in association with UCP1 activation and adiponectin elevation. Furthermore, LAX noticeably improved the levels of fasting blood glucose, serum insulin, and HOMA‐IR through positive regulation of glucose transporters (GLUT2, GLUT4), and insulin receptor gene expression. In conclusion, the fermentation of AX demonstrates a pronounced mitigation of overnutrition‐induced metabolic dysfunction, including hyperlipidemia, hyperglycemia, hyperinsulinemia, and obesity, compared to non‐fermented AX. Consequently, we proposed that the fermentation of AX holds promise as a potential candidate for effectively ameliorating metabolic disorders.

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Assessment of Inflammatory Hematological Ratios (NLR, PLR, MLR, LMR and Monocyte/HDL–Cholesterol Ratio) in Acute Myocardial Infarction and Particularities in Young Patients

Cited by 29 publications

References 79 publications

An Evaluation of the Hematological Markers of Systemic Inflammation and Oxidative Stress in Vitiligo: A Case-Control Study

An Evaluation of the Hematological Markers of Systemic Inflammation and Oxidative Stress in Vitiligo: A Case-Control Study

The neutrophil-to-lymphocyte ratio is associated with all-cause and cardiovascular mortality among individuals with hypertension

Lactobacillus casei‐fermented Amomum xanthioides ameliorates metabolic dysfunction in high‐fat diet‐induced obese mice

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